Chemical Name: [3-[4-[2-[5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-1,3-benzodiazol-2-yl]ethyl]phenoxy]propyl]dimethylamine
Biological ActivityDual CBP/p300 and BRD4 bromodomain inhibitor (IC50 values are 0.65 and 1.5 μM for CBP and BRD4 respectively). Downregulates IL-6, IL-1β and IFN-β in macrophages.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities.
Chekler et al.
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