Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50
= 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50
= 3 - 21 nM) and in human xenografts in vivo
. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50
= 210 nM) and acts as a microtubule depolymerizing agent in vitro
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A small-molecule antagonist of the hedgehog signaling pathway.
Lee et al.
The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling.
Cupido et al.