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JK 184

Catalog #: 3341
1 Citation Datasheet / COA / SDS

Discontinued Product

3341 has been discontinued.
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JK 184 | CAS No. 315703-52-7 | Dehydrogenase Inhibitors
1 Image
Description: Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway

Chemical Name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

JK 184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro.

Technical Data

M.Wt:
350.44
Formula:
C19H18N4OS
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
315703-52-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A small-molecule antagonist of the hedgehog signaling pathway.
    Lee et al.
    Chembiochem., 2007;8:1916
  2. The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling.
    Cupido et al.
    Angew.Chem.Int.Ed.Engl., 2009;48:2321

Product Datasheets

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Citation for JK 184

The citations listed below are publications that use Tocris products. Selected citations for JK 184 include:

1 Citation: Showing 1 - 1

  1. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.
    Authors: Oladapo
    Cancer Lett  2017;411:136

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