Chemical Name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine
Biological ActivityPotent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A small-molecule antagonist of the hedgehog signaling pathway.
Lee et al.
The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling.
Cupido et al.
Citation for JK 184
The citations listed below are publications that use Tocris products. Selected citations for JK 184 include:
1 Citation: Showing 1 - 1
Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.
Cancer Lett 2017;411:136
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