JLK 6
Description: Inhibitor of γ-secretase-mediated βAPP processing
Chemical Name: 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
Purity: ≥99%
Biological Activity
JLK 6 is an inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Prevents recovery of Aβ40 and Aβ42 from HEK293 cell overexpressing wild-type or Swedish-mutated βAPP (IC50 ~ 30 μM) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α-secretase, the proteosome or GSK3β.Technical Data
M.Wt:
225.63
Formula:
C10H8ClNO3
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
62252-26-0
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Background References
-
New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage.
Petit et al.
Nat.Cell.Biol., 2001;3:507 -
JLK isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with Notch pathway in vitro or in vivo.
Petit et al.
J.Neurosci.Res., 2003;74:370 -
DII4 signalling through Notch1 regulates formation of tip cells during angiogenesis.
Hellstrom et al.
Nature, 2007;445:776
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