Chemical Name: 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
Biological Activity Inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Prevents recovery of Aβ40 and Aβ42 from HEK293 cell overexpressing wild-type or Swedish-mutated βAPP (IC50 ~ 30 μM) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α-secretase, the proteosome or GSK3β.
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Store at RT
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