JNJ 27141491

Catalog # Availability Size / Price Qty
5176/10
5176/50
Cat.No. 5176 - JNJ 27141491 | C17H15F2N3O3S | CAS No. 871313-59-6
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Description: Potent and selective human CCR2 antagonist

Chemical Name: 3-[(1S)-1-(3,4-Difluorophenyl)propyl]-2,3-dihydro-5-(5-isoxazolyl)-2-thioxo-1H-imidazole-4-carboxylic acid methyl ester

Purity: ≥98%

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Biological Activity

Potent, noncompetitive human CCR2 antagonist; inhibits MCP-1-induced Ca2+ mobilization in hCCR2-CHO cells (IC50 = 13 nM). Exhibits selectivity for CCR2 over CCR1, CCR3-8 and CXCR1-3. Delays onset and reduces neurological signs in an experimental autoimmune encephalomyelitis model of multiple sclerosis in hCCR2 knock-in mice. Orally active.

Technical Data

M.Wt:
379.38
Formula:
C17H15F2N3O3S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
871313-59-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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