JNJ 5207852 dihydrochloride

Catalog # Availability Size / Price Qty
4020/10
4020/50
JNJ 5207852 dihydrochloride | CAS No. 1782228-76-5 | Histamine H3 Receptor Antagonists
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Description: High affinity H3 antagonist

Chemical Name: 1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochloride

Purity: ≥99%

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Biological Activity

High affinity histamine H3 receptor neutral antagonist (pKi values are 8.9 and 9.2 in rat and human respectively). Brain penetrant and orally active. Has 3- and 100-fold higher affinity than thioperamide (Cat. No. 0644) for rat and human H3 receptors respectively. Suppresses slow-wave sleep; exhibits wake-promoting effects in rodent arousal models.

Technical Data

M.Wt:
389.4
Formula:
C20H32N2O.2HCl
Solubility:
Soluble to 50 mM in water and to 20 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1782228-76-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

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