JNJ 5207852 dihydrochloride

Key Product Details

Product Description

JNJ 5207852 dihydrochloride is a high affinity histamine H₃ receptor neutral antagonist (pK_i values are 8.9 and 9.2 in rat and human respectively). Brain penetrant and orally active. Has 3- and 100-fold higher affinity than thioperamide (Cat. No. 0644) for rat and human H₃ receptors respectively. Suppresses slow-wave sleep; exhibits wake-promoting effects in rodent arousal models.

Licensing Information

Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

Product Specifications for JNJ 5207852 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for JNJ 5207852 dihydrochloride

The following data is based on the product molecular weight 389.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.14 mL	25.68 mL	51.36 mL
2.5 mM	1.03 mL	5.14 mL	10.27 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
25 mM	0.10 mL	0.51 mL	1.03 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Jia Effects of histamine H₃ antagonists and donep. on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice. Neuropharmacology 2005 PMID: 16310812
• Le Correlation between ex vivo receptor occupancy and wake-promoting activity of selective H₃ receptor antagonists. J.Pharmacol.Exp.Ther. 2008 PMID: 18305012
• Barbier Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H₃ antagonist. Br.J.Pharmacol. 2004 PMID: 15466448

Product Documents for JNJ 5207852 dihydrochloride