LDN 193189 in solution

Name: LDN 193189 in solution
Brand: Tocris Bioscience
SKU: 8150
Price: 252 USD
Availability: InStock

Tocris Bioscience | Catalog # 8150

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Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water

Technical Data
Reviews

Product Description
Licensing Information
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water

View all BMP and Other Activin Receptor Inhibitors »

Product Description

LDN 193189 in solution is a convenient and ready-to-use 10 mM sterile-filtered solution of LDN 193189 pre-dissolved in water. A potent and selective ALK2 and ALK3 inhibitor (IC₅₀ values are 5 nM and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Promotes neural induction of hPSCs in combination with SB 431542 (Cat. No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat. No. 1614), SU 5402 (Cat. No. 3300), CHIR 99021 (Cat. No. 4423) and DAPT (Cat. No. 2634).

Licensing Information

Sold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patents 8,507,501 and 9,045,484

Product Specifications for LDN 193189 in solution

Molecular Weight

479.41

Formula

C₂₅H₂₂N₆.2HCl

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride

CAS Number

1435934-00-1

InChI Key

CMQXLLAILGGLRV-UHFFFAOYSA-N

SMILES

N1(C2=CC=C(C3=CN4N=CC(C5=CC=NC6=C5C=CC=C6)=C4N=C3)C=C2)CCNCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

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Background References

References are publications that support the biological activity of the product.

Lancaster Generation of cerebral organoids from human pluripotent stem cells. Nat.Protoc. 2015 PMID: 25188634
Li Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 2013 PMID: 24012368
Chambers Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat.Biotechnol. 2012 PMID: 22750882
Cuny Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg.Med.Chem.Lett. 2008 PMID: 18621530
Yu BMP type I receptor inhibition reduces heterotopic ossification. Nat.Med. 2008 PMID: 19029982

Product Documents for LDN 193189 in solution

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for LDN 193189 in solution

For research use only

Related Research Areas

BMP Family

Early Mesodermal Lineage Markers

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