Biological ActivityHigh affinity, selective KCa2.2 (SK2) channel blocker (Kd = 3.8 nM). Exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, IK, Kv and Kir2.1. Increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. Convulsive in vivo.
(Modifications: X = Dab, Disulfide bridges: 3-21, 8-26, 12-28, His-31 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.
Shakkottai et al.
A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor.
Kramar et al.
Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2.
Kasumu et al.
Citation for Lei-Dab 7
The citations listed below are publications that use Tocris products. Selected citations for Lei-Dab 7 include:
1 Citation: Showing 1 - 1
Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels
Authors: Sargin Et al.
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The product is a great high affinity calcium-activated potassium channel activator which shows great variation in concentration dependent channel opening. The product works ideally on labs and the data produced can be easily reproduced. One con of the product will be that it has very little safety data accompanying it.