Catalog Number: 5571
Biological Activity
High affinity, selective KCa2.2 (SK2) channel blocker (Kd = 3.8 nM). Exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, IK, Kv and Kir2.1. Increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. Convulsive in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: X = Dab, Disulfide bridges: 3-21, 8-26, 12-28, His-31 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.
    Shakkottai et al.
    J.Biol.Chem., 2001;276:43145
  2. A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor.
    Kramar et al.
    J.Neurosci., 2004;24:5151
  3. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2.
    Kasumu et al.
    Chem.Biol., 2012;19:1340
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