Lei-Dab 7

Catalog # Availability Size / Price Qty
5571/100U
Ca2+-Activated Potassium Channel Blockers Peptide
1 Image
Description: High affinity, selective KCa2.2 blocker
Product Details
Citations (1)
Reviews (1)

Biological Activity

High affinity, selective KCa2.2 (SK2) channel blocker (Kd = 3.8 nM). Exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, IK, Kv and Kir2.1. Increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. Convulsive in vivo.

Technical Data

M.Wt:
3392.06
Formula:
C141H236N46O39S6
Sequence:
AFCNLRXCQLSCRSLGLLGKCIGDKCECVKH

(Modifications: X = Dab, Disulfide bridges: 3-21, 8-26, 12-28, His-31 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
1061556-49-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for Lei-Dab 7

The citations listed below are publications that use Tocris products. Selected citations for Lei-Dab 7 include:

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FAQs

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Reviews for Lei-Dab 7

Average Rating: 4 (Based on 1 Review)

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Great Kca activator which performs ideally on cell culture labs
By Anonymous on 10/23/2018
Species: Human

The product is a great high affinity calcium-activated potassium channel activator which shows great variation in concentration dependent channel opening. The product works ideally on labs and the data produced can be easily reproduced. One con of the product will be that it has very little safety data accompanying it.


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