High affinity, selective KCa
2.2 (SK2) channel blocker (Kd
= 3.8 nM). Exhibits >200-fold selectivity for KCa
2.2 over KCa
3.1, IK, Kv
2.1. Increases theta-burst responses and increases LTP in rat hippocampal slices in vitro
. Convulsive in vivo
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Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.
Shakkottai et al.
A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor.
Kramar et al.
Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2.
Kasumu et al.