Leptomycin B

Name: Leptomycin B
Brand: Tocris Bioscience
SKU: 1987

Tocris Bioscience | Catalog # 1987

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Citations (653)

Product Documents

Inhibits nuclear export of proteins; antitumor

Discontinued Product

1987 has been discontinued. View all Translocation, Exo/Endocytosis Products products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Inhibits nuclear export of proteins; antitumor

Alternative Names

CI 940,LMB

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Product Description

Leptomycin B is an antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo.

Product Specifications for Leptomycin B

Molecular Weight

540.74

Formula

C₃₃H₄₈O₆

Storage

Desiccate at -20°C

Chemical Name

(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

CAS Number

87081-35-4

PubChem ID

57459335

InChI Key

YACHGFWEQXFSBS-RJXCBBHPSA-N

SMILES

CCC(\C=C\[C@@H]1OC(=O)C=C[C@@H]1C)=C/[C@H](C)C\C=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 27µg/ml)

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 653 publications citing the usage of this product.

Kudo Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp.Cell Res. 1998 PMID: 9683540
Wolff Leptomycin B is an inhibitor of nuclear export: inhibition of nucleocytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem.Biol. 1997 PMID: 9190288
Freedman and Levine Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol.Cell.Biol. 1998 PMID: 9819415
Roberts In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI 940 and its hydroxy analog (PD 114,721). Cancer Chemother.Pharmacol. 1986 PMID: 3081269

Product Documents for Leptomycin B

Certificate of Analysis

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Product Specific Notices for Leptomycin B

For research use only

Citations for Leptomycin B

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