Leptomycin B

  ( 3 citations )    
Product Datasheet
Catalog Number:1987
Alternate Names:CI 940, LMB
Chemical Name:(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
Product Details
Citations (3)
Reviews
Biological Activity
Antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo.
Technical Data
  • M.Wt:
    540.74
  • Formula:
    C33H48O6
  • Solubility:
    Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 27?g/ml)
  • Storage:
    Desiccate at -20°C
  • CAS No:
    87081-35-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Leptomycin B include:

3 Citations: Showing 1 - 3
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  1. Characterization of the nucleocytoplasmic shuttle of the matrix protein of influenza B virus.
    Authors: Cao Et al.
    J Virol  2014;88:7464
  2. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors.
    Authors: Horan Et al.
    J Immunol  2013;190:2311
  3. A nuclear export signal in the matrix protein of Influenza A virus is required for efficient virus replication.
    Authors: Cao Et al.
    J Virol  2012;86:4883

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