Antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro
and in vivo
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In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI 940 and its hydroxy analog (PD 114,721).
Roberts et al.
Cancer Chemother.Pharmacol., 1986;16:95
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleocytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA.
Wolff et al.
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6.
Freedman and Levine
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1.
Kudo et al.
Exp.Cell Res., 1998;242:540
The citations listed below are publications that use Tocris products. Selected citations for Leptomycin B include:
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