Leptomycin B
Discontinued Product
Chemical Name: (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
Biological Activity
Leptomycin B is an antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI 940 and its hydroxy analog (PD 114,721).
Roberts et al.
Cancer Chemother.Pharmacol., 1986;16:95 -
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleocytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA.
Wolff et al.
Chem.Biol., 1997;4:139 -
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6.
Freedman and Levine
Mol.Cell.Biol., 1998;18:7288 -
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1.
Kudo et al.
Exp.Cell Res., 1998;242:540
Product Datasheets
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Citations for Leptomycin B
The citations listed below are publications that use Tocris products. Selected citations for Leptomycin B include:
4 Citations: Showing 1 - 4
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Naproxen Exhibits Broad Anti-influenza Virus Activity in Mice by Impeding Viral Nucleoprotein Nuclear Export.
Authors: Zheng Et al.
Cell Rep 2019;27:1875
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Characterization of the nucleocytoplasmic shuttle of the matrix protein of influenza B virus.
Authors: Cao Et al.
J Virol 2014;88:7464
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Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors.
Authors: Horan Et al.
J Immunol 2013;190:2311
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A nuclear export signal in the matrix protein of Influenza A virus is required for efficient virus replication.
Authors: Cao Et al.
J Virol 2012;86:4883
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