Leptomycin B

Catalog # Availability Size / Price Qty
1987/5U
Leptomycin B | CAS No. 87081-35-4 | Translocation, Exo/Endocytosis Products
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Description: Inhibits nuclear export of proteins; antitumor
Alternative Names: CI 940, LMB

Chemical Name: (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

Product Details
Citations (4)
Reviews

Biological Activity

Antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo.

Technical Data

M.Wt:
540.74
Formula:
C33H48O6
Solubility:
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 27?g/ml)
Storage:
Desiccate at -20°C
CAS No:
87081-35-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Leptomycin B

The citations listed below are publications that use Tocris products. Selected citations for Leptomycin B include:

4 Citations: Showing 1 - 4

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