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Liquiritigenin

Catalog #: 3819
1 Citation Datasheet / COA / SDS

Discontinued Product

3819 has been discontinued.
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Liquiritigenin | CAS No. 578-86-9 | Estrogen and Related Receptor Agonists
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Description: Selective ERβ agonist

Chemical Name: (S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent ERβ agonist isolated from licorice root (EC50 = 36.5 nM for activation of the ERE tk-Luc reporter by ERβ in transfected U2OS cells). Displays 20-fold selectivity for ERβ; does not activate other nuclear receptors, including the androgen and glucocorticoid receptors. Displays anti-inflammatory effects.

Technical Data

M.Wt:
256.25
Formula:
C15H12O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
578-86-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Estradiol antagonism of glucocorticoid-induced GILZ expression in human uterine epithelial cells and murine uterus.
    Whirledge S, Cidlowski J
    Endocrinology, 2013;154(1):499-510.
  2. Flavonoid glucosides from licorice.
    Yahara and Nishioka
    Phytochemistry, 1984;23:2108
  3. Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist.
    Mersereau et al.
    Mol.Cell.Endocrinol., 2008;283:49
  4. Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NK-kappaB-dependent iNOS and proinflammatory cytokines production.
    Kim et al.
    Br.J.Pharmacol., 2008;154:165

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Citation for Liquiritigenin

The citations listed below are publications that use Tocris products. Selected citations for Liquiritigenin include:

1 Citation: Showing 1 - 1

  1. Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens.
    Authors: Gong Et al.
    Nucl Recept Signal  2014;12:e001

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