Liquiritigenin

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3819/10
Liquiritigenin | CAS No. 578-86-9 | Estrogen and Related Receptor Agonists
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Description: Selective ERβ agonist

Chemical Name: (S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Potent ERβ agonist isolated from licorice root (EC50 = 36.5 nM for activation of the ERE tk-Luc reporter by ERβ in transfected U2OS cells). Displays 20-fold selectivity for ERβ; does not activate other nuclear receptors, including the androgen and glucocorticoid receptors. Displays anti-inflammatory effects.

Technical Data

M.Wt:
256.25
Formula:
C15H12O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
578-86-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Flavonoid glucosides from licorice.
    Yahara and Nishioka
    Phytochemistry, 1984;23:2108
  2. Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist.
    Mersereau et al.
    Mol.Cell.Endocrinol., 2008;283:49
  3. Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NK-kappaB-dependent iNOS and proinflammatory cytokines production.
    Kim et al.
    Br.J.Pharmacol., 2008;154:165

Product Datasheets

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Citation for Liquiritigenin

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