Catalog Number: 3819
Chemical Name: (S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Biological Activity
Potent ERβ agonist isolated from licorice root (EC50 = 36.5 nM for activation of the ERE tk-Luc reporter by ERβ in transfected U2OS cells). Displays 20-fold selectivity for ERβ; does not activate other nuclear receptors, including the androgen and glucocorticoid receptors. Displays anti-inflammatory effects.
Technical Data
  • M.Wt:
    256.25
  • Formula:
    C15H12O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    578-86-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist.
    Mersereau et al.
    Mol.Cell.Endocrinol., 2008;283:49
  2. Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NK-kappaB-dependent iNOS and proinflammatory cytokines production.
    Kim et al.
    Br.J.Pharmacol., 2008;154:165
  3. Flavonoid glucosides from licorice.
    Yahara
    Phytochemistry, 1984;23:2108
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Liquiritigenin include:

1 Citations: Showing 1 - 1

  1. Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens.
    Authors: Gong Et al.
    Nucl Recept Signal 2014;12:e001

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