Potent SMYD2 inhibitor (IC50
= 15 nM). Exhibits >100-fold selectivity for SMYD2 over 25 other methyltransferases including SMYD3, SUV420H1 and SUV420H2. Inhibits SMYD2-mediated p53 methylation in vitro
. Also inhibits proliferation of a range of esophageal, liver and breast cancer cell lines.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the LLY 507 probe summary
on the SGC website.
LLY-507, a cell-active, potent, and selective inhibitor of protein-lysine methyltransferase SMYD2.
Nguyen et al.