Catalog Number: 4084
Biological Activity
Neuroprotective peptide that binds to amyloid beta (Aβ). Protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo. Potential therapeutic in the treatment of Alzheimer's Disease.
Technical Data
  • M.Wt:
    652.75
  • Formula:
    C33H44N6O8
  • Sequence:
    LPYFD-NH2

    (Modifications: Asp-5 = C-terminal amide)

  • Solubility:
    Soluble to 2 mg/ml in 10% acetonitrile / water
  • Storage:
    Store at -20°C
  • CAS No:
    700361-48-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pentapeptides derived from Aβ1-42 protect neurons from the modulatory effects of Aβ fibrils- an in vitro and in vivo electrophysiological study.
    Szegedi et al.
    Neurobiology of Disease, 2005;18:499
  2. An intraperitoneally administered pentapeptide protects against Aβ (1-42) induced neuronal excitation in vivo.
    Juhasz et al.
    J.Alzheimer's Dis., 2009;16:189

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