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LPYFD-NH2

4084 Datasheet / COA / SDS

Discontinued Product

4084 has been discontinued.
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LPYFD-NH2
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Description: Binds Aβ; protects from aggregation induced toxicity
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Biological Activity

LPYFD-NH2 is a neuroprotective peptide that binds to amyloid beta (Aβ). Protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo. Potential therapeutic in the treatment of Alzheimer's Disease.

Technical Data

M.Wt:
652.75
Formula:
C33H44N6O8
Sequence:
LPYFD-NH2

(Modifications: Asp-5 = C-terminal amide)

Solubility:
Soluble to 2 mg/ml in 10% acetonitrile / water
Storage:
Store at -20°C
CAS No:
700361-48-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pentapeptides derived from Aβ1-42 protect neurons from the modulatory effects of Aβ fibrils- an in vitro and in vivo electrophysiological study.
    Szegedi et al.
    Neurobiology of Disease, 2005;18:499
  2. An intraperitoneally administered pentapeptide protects against Aβ (1-42) induced neuronal excitation in vivo.
    Juhasz et al.
    J.Alzheimer's Dis., 2009;16:189

Product Datasheets

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Reconstitution Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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