Biological ActivityLPYFD-NH2 is a neuroprotective peptide that binds to amyloid beta (Aβ). Protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo. Potential therapeutic in the treatment of Alzheimer's Disease.
(Modifications: Asp-5 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pentapeptides derived from Aβ1-42 protect neurons from the modulatory effects of Aβ fibrils- an in vitro and in vivo electrophysiological study.
Szegedi et al.
Neurobiology of Disease, 2005;18:499
An intraperitoneally administered pentapeptide protects against Aβ (1-42) induced neuronal excitation in vivo.
Juhasz et al.
J.Alzheimer's Dis., 2009;16:189
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