Catalog Number: 5103
Chemical Name: S-[2-[[(5S)-5-(Acetylamino)-6-amino-6-oxohexyl]amino]-2-oxoethyl]coenzyme A trifluoroacetate
Biological Activity
Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo.
Technical Data
  • M.Wt:
    1108.82
  • Formula:
    C31H53N10O19P3S.C2HF3O2
  • Solubility:
    Soluble to 6 mM in water
  • Purity:
    >95%
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.
    Lau et al.
    Mol.Cell., 2000;5:589
  2. The structural basis of protein acetylation by the p300/CBP transcriptional coactivator.
    Liu et al.
    Nature., 2008;451:846
  3. Iso-coenzyme A.
    Burns et al.
    J.Biol.Chem., 2005;280:16550
  4. Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300.
    Cebrat et al.
    Bioorg.Med.Chem., 2003;11:3307
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