M 25

Catalog # Availability Size / Price Qty
4917/10
4917/50
Cat.No. 4917 - M 25 | C23H29N3O2
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Description: Potent Smoothened (Smo) receptor antagonist

Chemical Name: N-[[1-(2-Methoxyphenyl)-1H-indazol-5-yl]methyl]-2-propylpentanamide

Purity: ≥98%

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Biological Activity

Potent Smoothened (Smo) receptor antagonist (IC50 = 5 nM). Inhibits the Hedgehog signaling pathway. Inhibits Shh induced Gli luciferase reporter activity in Shh-light 2 cells (IC50 = 5 nM). Antagonizes GSA-10 and SAG-mediated differentiation of the C3H10T1/2 cell line (IC50 values are 69 and 115 nM, respectively).

Technical Data

M.Wt:
379.5
Formula:
C23H29N3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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