M 30 dihydrochloride

Name: M 30 dihydrochloride
Brand: Tocris Bioscience
SKU: 6067
Price: 120 USD

Catalog #: 6067
1 Citation Datasheet / COA / SDS

Discontinued Product

6067 has been discontinued.

View all Monoamine Oxidase (MAO) Inhibitors products.

M 30 dihydrochloride | CAS No. 64821-19-8 | Monoamine Oxidase (MAO) Inhibitors

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Description: Potent and non-selective MAO inhibitor; also an iron chelator and antioxidant

Chemical Name: N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride

Purity: ≥98%

View All Products for Monoamine Oxidase (MAO) Inhibitors

Product Details

Citations (1)

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Biological Activity

M 30 dihydrochloride is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC₅₀ values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA (Cat. No. 2547) induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model.

Technical Data

M.Wt:

299.2

Formula:

C₁₄H₁₄N₂O.2HCl

Solubility:

Soluble to 100 mM in water

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

64821-19-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons.
Zheng et al.
Biochem.Pharmacol., 2005;70:1642
Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition.
Zheng
J.Neurochem., 2005;95:68
Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal DA depletion.
Gal et al.
J.Neurochem., 2005;95:79

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for M 30 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for M 30 dihydrochloride include:

1 Citation: Showing 1 - 1

Endogenously produced catecholamines improve the regulatory function of TLR9-activated B cells.
Authors: Matthias Et al.
PLoS Biol 2022;20:e3001513

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