Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate

Name: Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate
Brand: R&D Systems
SKU: ES001
Price: 562 USD
Availability: InStock

R&D Systems | Catalog # ES001

Submit a review

Citations (68)

Product Documents

Substrate for MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, MMP-15, MMP-16, Cathepsin D, and Cathepsin E

100% Guarantee

Product Specifications
Spectra Viewer
Preparation & Storage
Product Documents
Specific Notices
Research Areas

Key Product Details

Conjugate

7-Methoxycoumarin

Applications

Binding Activity, Bioactivity

View all Protease Substrates Fluorescent Probes and Dyes »

Product Specifications

Source

Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
Mca: (7-Methoxycoumarin-4-yl)acetyl, Dpa: N-3-(2, 4-Dinitrophenyl)-L-2,3-diaminopropionyl.

Predicted Molecular Mass

1093 Da

Activity

The peptide substrate contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2, 4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence.

It is also an excellent substrate for active Cathepsins D and E.

Spectra Viewer

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectra Viewer

Formulation, Preparation, and Storage

ES001

Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20° C to -70° C. The substrate can be aliquoted and stored -20° C to -70° C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light.