Mecamylamine hydrochloride

  ( 16 citations )    
Product Datasheet
Catalog Number:2843
Chemical Name:N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
Product Details
Citations (16)
Reviews
Biological Activity
Non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.
Technical Data
  • M.Wt:
    203.75
  • Formula:
    C11H21N.HCl
  • Solubility:
    Soluble to 100 mM in water and to 75 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
    826-39-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mecamylamine hydrochloride include:

16 Citations: Showing 1 - 10
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  1. Differential processing of thalamic information via distinct striatal interneuron circuits.
    Authors: Assous
    Nat Commun  2017;8:15860
  2. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission
    Authors: Mamaligas Et al.
    Scientific Reports  2016;6:37834
  3. Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology.
    Authors: Kam Et al.
    Proc Natl Acad Sci U S A  2016;6:20119
  4. A cholinergic basal forebrain feeding circuit modulates appetite suppression
    Authors: Herman Et al.
    Nature  2016;538:253
  5. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
    Authors: Elgueta Et al.
    PLoS One  2015;9:6
  6. Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward.
    Authors: Stouffer Et al.
    Nat Commun  2015;6:8543
  7. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    Sci Rep  2015;4
  8. Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks.
    Authors: Dannenberg Et al.
    J Neurosci  2015;35:8394
  9. Cholinergic control of γ power in the midbrain spatial attention network.
    Authors: Bryant Et al.
    Elife  2015;35:761
  10. Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
    Authors: Liu Et al.
    Front Cell Neurosci  2015;35:5680
  11. Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca.
    Authors: Leão Et al.
    J Neurosci  2015;113:971
  12. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    J Neurophysiol  2015;112:8124
  13. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Eur J Neurosci  2015;10:e0131430
  14. Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats.
    Authors: Costello Et al.
    Neuropsychopharmacology  2014;39:1843
  15. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.
    Authors: Higley Et al.
    PLoS One  2011;6:e19155
  16. Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness.
    Authors: Zhang Et al.
    J Biol Chem  2011;286:25331
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