Mecamylamine hydrochloride

Catalog # Availability Size / Price Qty
Mecamylamine hydrochloride | CAS No. 110691-49-1 | Additional Nicotinic Receptor Antagonists
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Description: Non-competitive nAChR antagonist

Chemical Name: (1R,2S,4S)-rel-N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride

Product Details
Citations (21)

Biological Activity

Mecamylamine hydrochloride is a non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells

    Nat Commun, 2016;7(0):12961.
  2. Modeling study of mecamylamine block of muscle type acetylcholine receptors.
    Ostroumov et al.
    Eur.Biophys.J., 2007;37:393
  3. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice.
    Rabenstein et al.
    Psychopharmacol., 2006;189:395

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Citations for Mecamylamine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Mecamylamine hydrochloride include:

21 Citations: Showing 1 - 10

  1. Chronology-based architecture of descending circuits that underlie the development of locomotor repertoire after birth.
    Authors: Pujala and Koyama
    Elife  2019;8
  2. GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.
    Authors: Lozovaya Et al.
    Nat Commun  2018;9(1):1422
  3. The Coordinated Activities of nAChR and Wnt Signaling Regulate Intestinal Stem Cell Function in Mice.
    Authors: Takahashi Et al.
    Int J Mol Sci  2018;19
  4. Developmental nicotine exposure affects larval brain size and the adult dopaminergic system of Drosophila melanogaster.
    Authors: Morris Et al.
    BMC Dev Biol  2018;18:13
  5. Differential processing of thalamic information via distinct striatal interneuron circuits.
    Authors: Assous
    Nat Commun  2017;8:15860
  6. Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells.
    Authors: Sternfeld Et al.
    Elife  2017;6
  7. Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission
    Authors: Mamaligas Et al.
    Scientific Reports  2016;6:37834
  8. Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology.
    Authors: Kam Et al.
    Proc Natl Acad Sci U S A  2016;6:20119
  9. A cholinergic basal forebrain feeding circuit modulates appetite suppression
    Authors: Herman Et al.
    Nature  2016;538:253
  10. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
    Authors: Elgueta Et al.
    PLoS One  2015;9:6
  11. Ins enhances striatal DA release by activating cholinergic interneurons and thereby signals reward.
    Authors: Stouffer Et al.
    Nat Commun  2015;6:8543
  12. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    Sci Rep  2015;4
  13. Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks.
    Authors: Dannenberg Et al.
    J Neurosci  2015;35:8394
  14. Cholinergic control of γ power in the midbrain spatial attention network.
    Authors: Bryant Et al.
    Elife  2015;35:761
  15. Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
    Authors: Liu Et al.
    Front Cell Neurosci  2015;35:5680
  16. Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca.
    Authors: Leão Et al.
    J Neurosci  2015;113:971
  17. Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    J Neurophysiol  2015;112:8124
  18. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Eur J Neurosci  2015;10:e0131430
  19. Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats.
    Authors: Costello Et al.
    Neuropsychopharmacology  2014;39:1843
  20. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.
    Authors: Higley Et al.
    PLoS One  2011;6:e19155
  21. Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness.
    Authors: Zhang Et al.
    J Biol Chem  2011;286:25331


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