Catalog Number: 2843
Chemical Name: N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
Biological Activity
Non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 75 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modeling study of mecamylamine block of muscle type acetylcholine receptors.
    Ostroumov et al.
    Eur.Biophys.J., 2007;37:393
  2. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice.
    Rabenstein et al.
    Psychopharmacol., 2006;189:395

The citations listed below are publications that use Tocris products. Selected citations for Mecamylamine hydrochloride include:

Showing Results 1 - 10 of 12

  1. Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology.
    Authors: Kam Et al.
    Proc Natl Acad Sci U S A
  2. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
    Authors: Elgueta Et al.
    PLoS One
  3. Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward.
    Authors: Stouffer Et al.
    Nat Commun
  4. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    Sci Rep
  5. Cholinergic control of γ power in the midbrain spatial attention network.
    Authors: Bryant Et al.
  6. Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
    Authors: Liu Et al.
    Front Cell Neurosci
  7. Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca.
    Authors: Leão Et al.
    J Neurosci
  8. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    J Neurophysiol
  9. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Eur J Neurosci
  10. Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats.
    Authors: Costello Et al.
  11. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.
    Authors: Higley Et al.
    PLoS One
  12. Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness.
    Authors: Zhang Et al.
    J Biol Chem
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