Chemical Name: N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
Biological ActivityNon-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Modeling study of mecamylamine block of muscle type acetylcholine receptors.
Ostroumov et al.
The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice.
Rabenstein et al.
Citations for Mecamylamine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Mecamylamine hydrochloride include:
21 Citations: Showing 1 - 10
Chronology-based architecture of descending circuits that underlie the development of locomotor repertoire after birth.
Authors: Pujala and Koyama
GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.
Authors: Lozovaya Et al.
Nat Commun 2018;9(1):1422
The Coordinated Activities of nAChR and Wnt Signaling Regulate Intestinal Stem Cell Function in Mice.
Authors: Takahashi Et al.
Int J Mol Sci 2018;19
Developmental nicotine exposure affects larval brain size and the adult dopaminergic system of Drosophila melanogaster.
Authors: Morris Et al.
BMC Dev Biol 2018;18:13
Differential processing of thalamic information via distinct striatal interneuron circuits.
Nat Commun 2017;8:15860
Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells.
Authors: Sternfeld Et al.
Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission
Authors: Mamaligas Et al.
Scientific Reports 2016;6:37834
Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology.
Authors: Kam Et al.
Proc Natl Acad Sci U S A 2016;6:20119
A cholinergic basal forebrain feeding circuit modulates appetite suppression
Authors: Herman Et al.
Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
Authors: Elgueta Et al.
PLoS One 2015;9:6
Ins enhances striatal DA release by activating cholinergic interneurons and thereby signals reward.
Authors: Stouffer Et al.
Nat Commun 2015;6:8543
Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
Authors: Saunders Et al.
Sci Rep 2015;4
Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks.
Authors: Dannenberg Et al.
J Neurosci 2015;35:8394
Cholinergic control of γ power in the midbrain spatial attention network.
Authors: Bryant Et al.
Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
Authors: Liu Et al.
Front Cell Neurosci 2015;35:5680
Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca.
Authors: Leão Et al.
J Neurosci 2015;113:971
Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens.
Authors: Shin Et al.
J Neurophysiol 2015;112:8124
Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
Authors: Falgairolle and O'Donovan
Eur J Neurosci 2015;10:e0131430
Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats.
Authors: Costello Et al.
Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.
Authors: Higley Et al.
PLoS One 2011;6:e19155
Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness.
Authors: Zhang Et al.
J Biol Chem 2011;286:25331
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