Catalog Number: 2843
Chemical Name: N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
Biological Activity
Non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.
Technical Data
  • M.Wt:
    203.75
  • Formula:
    C11H21N.HCl
  • Solubility:
    Soluble to 100 mM in water and to 75 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
    826-39-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modeling study of mecamylamine block of muscle type acetylcholine receptors.
    Ostroumov et al.
    Eur.Biophys.J., 2007;37:393
  2. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice.
    Rabenstein et al.
    Psychopharmacol., 2006;189:395
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mecamylamine hydrochloride include:

15 Citations: Showing 1 - 10
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  1. Differential processing of thalamic information via distinct striatal interneuron circuits.
    Authors: Assous
    Nat Commun 2017;8:15860
  2. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission
    Authors: Mamaligas Et al.
    Scientific Reports 2016;6:37834
  3. Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology.
    Authors: Kam Et al.
    Proc Natl Acad Sci U S A 2016;6:20119
  4. A cholinergic basal forebrain feeding circuit modulates appetite suppression
    Authors: Herman Et al.
    Nature 2016;538:253
  5. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
    Authors: Elgueta Et al.
    PLoS One 2015;9:6
  6. Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward.
    Authors: Stouffer Et al.
    Nat Commun 2015;6:8543
  7. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    Sci Rep 2015;4
  8. Cholinergic control of γ power in the midbrain spatial attention network.
    Authors: Bryant Et al.
    Elife 2015;35:761
  9. Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
    Authors: Liu Et al.
    Front Cell Neurosci 2015;35:5680
  10. Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca.
    Authors: Leão Et al.
    J Neurosci 2015;113:971
  11. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    J Neurophysiol 2015;112:8124
  12. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Eur J Neurosci 2015;10:e0131430
  13. Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats.
    Authors: Costello Et al.
    Neuropsychopharmacology 2014;39:1843
  14. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.
    Authors: Higley Et al.
    PLoS One 2011;6:e19155
  15. Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness.
    Authors: Zhang Et al.
    J Biol Chem 2011;286:25331
Expand to show all 15 Citations

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