Peptide antagonist of the B2
bradykinin receptor (pKi
= 10.3); conformationally constrained cyclized analog of HOE 140
(Cat. No. 3014). Blocks hypotension and bronchoconstriction in vivo
. Displays selectivity for B2
over 29 other receptors and ion channels (pIC50
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Differences between peptide and nonpeptide B2 bradykinin receptor antagonists in blocking bronchoconstriction and hypotension induced by bradykinin in anesthetized guinea pigs
Tramontana et al.
Interaction of linear and cyclic peptide antagonists at the human B(2) kinin receptor.
Cucchi et al.
MEN 11270, a novel selective constrained peptide antagonist with high affinity at the human B2 kinin receptor.
Meini et al.