Biological ActivityMEN 11270 is a peptide antagonist of the B2 bradykinin receptor (pKi = 10.3); conformationally constrained cyclized analog of HOE 140 (Cat. No. 3014). Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other receptors and ion channels (pIC50 < 5.5).
(Modifications: Arg-1 = D-Arg, X-1 = Hyp, X-2 = Thi, X-3 = Dab, X-4 = D-Tic, X-5 = Oic, cyclized 7γ - 10α)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
MEN 11270, a novel selective constrained peptide antagonist with high affinity at the human B2 kinin receptor.
Meini et al.
Differences between peptide and nonpeptide B2 bradykinin receptor antagonists in blocking bronchoconstriction and hypotension induced by bradykinin in anesthetized guinea pigs
Tramontana et al.
Interaction of linear and cyclic peptide antagonists at the human B(2) kinin receptor.
Cucchi et al.
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VersaClone cDNA Plasmids
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