MEN 11270

Catalog # Availability Size / Price Qty
3978/500U
Bradykinin Receptor Antagonists Peptide
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Description: Selective B2 antagonist; analog of HOE 140 (Cat. No. 3014)
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Biological Activity

Peptide antagonist of the B2 bradykinin receptor (pKi = 10.3); conformationally constrained cyclized analog of HOE 140 (Cat. No. 3014). Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other receptors and ion channels (pIC50 < 5.5).

Technical Data

M.Wt:
1299.56
Formula:
C60H90N20O11S
Sequence:
RRPXGXXXXR

(Modifications: Arg-1 = D-Arg, X-1 = Hyp, X-2 = Thi, X-3 = Dab, X-4 = D-Tic, X-5 = Oic, cyclized 7γ - 10α)

Solubility:
Soluble to 1 mg/ml in 30% acetonitrile / water
Storage:
Store at -20°C
CAS No:
235082-52-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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