Catalog Number: 3978
Biological Activity
Peptide antagonist of the B2 bradykinin receptor (pKi = 10.3); conformationally constrained cyclized analog of HOE 140 (Cat. No. 3014). Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other receptors and ion channels (pIC50 < 5.5).
Technical Data
  • M.Wt:
    1299.56
  • Formula:
    C60H90N20O11S
  • Sequence:
    RRPXGXXXXR

    (Modifications: Arg-1 = D-Arg, X-1 = Hyp, X-2 = Thi, X-3 = Dab, X-4 = D-Tic, X-5 = Oic, cyclized 7γ - 10α)

  • Solubility:
    Soluble to 1 mg/ml in 30% acetonitrile / water
  • Storage:
    Store at -20°C
  • CAS No:
    235082-52-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differences between peptide and nonpeptide B2 bradykinin receptor antagonists in blocking bronchoconstriction and hypotension induced by bradykinin in anesthetized guinea pigs
    Tramontana et al.
    J.Pharmacol.Exp.Ther., 2001;296:1051
  2. Interaction of linear and cyclic peptide antagonists at the human B(2) kinin receptor.
    Cucchi et al.
    Peptides, 2002;23:1457
  3. MEN 11270, a novel selective constrained peptide antagonist with high affinity at the human B2 kinin receptor.
    Meini et al.
    J.Pharmacol.Exp.Ther., 1999;289:1250
Tocris Peptides
Description Application Cat# Citations Images  

HOE 140

3014 2  
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