Mifepristone

  ( 20 citations )    
Product Datasheet
Catalog Number:1479
Alternate Names:RU 486, RU 38486
Chemical Name:(11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one
Product Details
Citations (20)
Reviews
Biological Activity
Selective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo. Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone (Cat. No. 1126).
Technical Data
  • M.Wt:
    429.6
  • Formula:
    C29H35NO2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol with gentle warming
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    84371-65-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mifepristone include:

20 Citations: Showing 1 - 10
Filter your results:

  1. The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice.
    Authors: Lee Et al.
    Immune Network  2016;16:242
  2. Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase.
    Authors: Zarif Et al.
    Biol Reprod  2015;6:6862
  3. Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo.
    Authors: Reinhardt Et al.
    EMBO J  2015;34:1572
  4. A robust and reliable non-invasive test for stress responsivity in mice.
    Authors: Zimprich Et al.
    Front Behav Neurosci  2014;8:125
  5. Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents.
    Authors: Liu Et al.
    Mol Brain  2014;7:32
  6. A transgenic zebrafish model for monitoring glucocorticoid receptor activity.
    Authors: Krug Et al.
    Genes Brain Behav  2014;13:478
  7. The role of glucocorticoid receptors in dexamethasone-induced apoptosis of neuroprogenitor cells in the hippocampus of rat pups.
    Authors: Sze Et al.
    World J Gastroenterol  2013;2013:628094
  8. Wnt activation downregulates olfactomedin-1 in Fallopian tubal epithelial cells: a microenvironment predisposed to tubal ectopic pregnancy.
    Authors: Kodithuwakku Et al.
    Lab Invest  2012;92:256
  9. Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis.
    Authors: Shikatani Et al.
    PLoS One  2012;7:e46625
  10. Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus.
    Authors: Dorey Et al.
    Neuropsychopharmacology  2012;37:2870
  11. Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity.
    Authors: Luoma Et al.
    Steroids  2011;76:845
  12. Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and μ-opioid receptor heterodimerization and female-specific spinal morphine antinociception.
    Authors: Liu Et al.
    J Neurosci  2011;31:11836
  13. Glucocorticoid receptors in the prefrontal cortex regulate stress-evoked dopamine efflux and aspects of executive function.
    Authors: Butts Et al.
    Proc Natl Acad Sci U S A  2011;108:18459
  14. Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism.
    Authors: Urbanet Et al.
    J Neurophysiol  2010;95:4037
  15. Hepatocyte growth factor system in the mouse uterus: variation across the estrous cycle and regulation by 17-β-estradiol and progesterone.
    Authors: Zhang
    Neuroscience  2010;82:1037
  16. Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of dopamine and glucocorticoid receptors.
    Authors: Schwendt and McGinty
    J Neurosci  2010;168:96
  17. Stress-induced changes in nucleus accumbens glutamate synaptic plasticity.
    Authors: Campioni Et al.
    Oncotarget  2009;101:3192
  18. Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton.
    Authors: Mayanagi Et al.
    J Biol Chem  2008;283:31183
  19. Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats.
    Authors: Wood Et al.
    Neuropsychopharmacology  2006;31:2580
  20. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
    Authors: Yang Et al.
    Mediators Inflamm  2005;25:4288
Expand to show all Citations

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used Mifepristone?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee