Catalog Number: 1479
Alternate Names: RU 486, RU 38486
Chemical Name: (11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one
Biological Activity
Selective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo. Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone (Cat. No. 1126).
Technical Data
  • M.Wt:
    429.6
  • Formula:
    C29H35NO2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    84371-65-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. RU 38486: a potent antiglucocorticoid in vitro and in vivo.
    Gagne et al.
    J.Steroid Biochem., 1985;23:247
  2. Molecular mechanism of RU 486 action: a review.
    Mao et al.
    Mol.Cell.Biochem., 1992;109:1
  3. Binding of the anti-progestin RU 486 to rat ovary steroid receptors.
    Schrieber et al.
    Contraception, 1983;28:77
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mifepristone include:

17 Citations: Showing 1 - 10
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  1. The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice.
    Authors: Lee Et al.
    Immune Network 2016;16:242
  2. Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase.
    Authors: Zarif Et al.
    Biol Reprod 2015;6:6862
  3. Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo.
    Authors: Reinhardt Et al.
    EMBO J 2015;34:1572
  4. Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents.
    Authors: Liu Et al.
    Mol Brain 2014;7:32
  5. The role of glucocorticoid receptors in dexamethasone-induced apoptosis of neuroprogenitor cells in the hippocampus of rat pups.
    Authors: Sze Et al.
    World J Gastroenterol 2013;2013:628094
  6. Wnt activation downregulates olfactomedin-1 in Fallopian tubal epithelial cells: a microenvironment predisposed to tubal ectopic pregnancy.
    Authors: Kodithuwakku Et al.
    Lab Invest 2012;92:256
  7. Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis.
    Authors: Shikatani Et al.
    PLoS One 2012;7:e46625
  8. Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus.
    Authors: Dorey Et al.
    Neuropsychopharmacology 2012;37:2870
  9. Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity.
    Authors: Luoma Et al.
    Steroids 2011;76:845
  10. Glucocorticoid receptors in the prefrontal cortex regulate stress-evoked dopamine efflux and aspects of executive function.
    Authors: Butts Et al.
    Proc Natl Acad Sci U S A 2011;108:18459
  11. Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism.
    Authors: Urbanet Et al.
    J Neurophysiol 2010;95:4037
  12. Hepatocyte growth factor system in the mouse uterus: variation across the estrous cycle and regulation by 17-β-estradiol and progesterone.
    Authors: Zhang
    Neuroscience 2010;82:1037
  13. Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of dopamine and glucocorticoid receptors.
    Authors: Schwendt and McGinty
    J Neurosci 2010;168:96
  14. Stress-induced changes in nucleus accumbens glutamate synaptic plasticity.
    Authors: Campioni Et al.
    Oncotarget 2009;101:3192
  15. Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton.
    Authors: Mayanagi Et al.
    J Biol Chem 2008;283:31183
  16. Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats.
    Authors: Wood Et al.
    Neuropsychopharmacology 2006;31:2580
  17. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
    Authors: Yang Et al.
    Mediators Inflamm 2005;25:4288
Expand to show all 17 Citations

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