( 20 citations )    
Product Datasheet
Catalog Number:1479
Alternate Names:RU 486, RU 38486
Chemical Name:(11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one
Product Details
Citations (20)
Biological Activity
Selective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo. Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone (Cat. No. 1126).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for Mifepristone include:

20 Citations: Showing 1 - 10
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  1. The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice.
    Authors: Lee Et al.
    Immune Network  2016;16:242
  2. Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase.
    Authors: Zarif Et al.
    Biol Reprod  2015;6:6862
  3. Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo.
    Authors: Reinhardt Et al.
    EMBO J  2015;34:1572
  4. A robust and reliable non-invasive test for stress responsivity in mice.
    Authors: Zimprich Et al.
    Front Behav Neurosci  2014;8:125
  5. Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents.
    Authors: Liu Et al.
    Mol Brain  2014;7:32
  6. A transgenic zebrafish model for monitoring glucocorticoid receptor activity.
    Authors: Krug Et al.
    Genes Brain Behav  2014;13:478
  7. The role of glucocorticoid receptors in dexamethasone-induced apoptosis of neuroprogenitor cells in the hippocampus of rat pups.
    Authors: Sze Et al.
    World J Gastroenterol  2013;2013:628094
  8. Wnt activation downregulates olfactomedin-1 in Fallopian tubal epithelial cells: a microenvironment predisposed to tubal ectopic pregnancy.
    Authors: Kodithuwakku Et al.
    Lab Invest  2012;92:256
  9. Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis.
    Authors: Shikatani Et al.
    PLoS One  2012;7:e46625
  10. Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus.
    Authors: Dorey Et al.
    Neuropsychopharmacology  2012;37:2870
  11. Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity.
    Authors: Luoma Et al.
    Steroids  2011;76:845
  12. Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and μ-opioid receptor heterodimerization and female-specific spinal morphine antinociception.
    Authors: Liu Et al.
    J Neurosci  2011;31:11836
  13. Glucocorticoid receptors in the prefrontal cortex regulate stress-evoked dopamine efflux and aspects of executive function.
    Authors: Butts Et al.
    Proc Natl Acad Sci U S A  2011;108:18459
  14. Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism.
    Authors: Urbanet Et al.
    J Neurophysiol  2010;95:4037
  15. Hepatocyte growth factor system in the mouse uterus: variation across the estrous cycle and regulation by 17-β-estradiol and progesterone.
    Authors: Zhang
    Neuroscience  2010;82:1037
  16. Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of dopamine and glucocorticoid receptors.
    Authors: Schwendt and McGinty
    J Neurosci  2010;168:96
  17. Stress-induced changes in nucleus accumbens glutamate synaptic plasticity.
    Authors: Campioni Et al.
    Oncotarget  2009;101:3192
  18. Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton.
    Authors: Mayanagi Et al.
    J Biol Chem  2008;283:31183
  19. Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats.
    Authors: Wood Et al.
    Neuropsychopharmacology  2006;31:2580
  20. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
    Authors: Yang Et al.
    Mediators Inflamm  2005;25:4288
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