Chemical Name: 4-(E)-[[(2Z)-2-cyclohexylimino)-4-methyl-1,3-thiazol-3(2H)-yl]imino]methyl]benzene-1,2,3-triol
Biological ActivityInhibitor of Mcl-1. Inhibits Mcl-1 indirectly by induction of the proapoptotic Mcl-1 ligand NOXA via the unfolded protein response (UPR) pathway. Sensitizes leukemia cells to the Bcl-2 inhibitor venetoclax (ABT-199). Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.
Cohen et al.
Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477.
Mallick et al.
Cell Death Dis., 2019;10:185
Citation for MIM1
The citations listed below are publications that use Tocris products. Selected citations for MIM1 include:
1 Citation: Showing 1 - 1
The androgen receptor mediates antiapoptotic function in myometrial cells.
Authors: Li Et al.
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