MIM1
Chemical Name: 4-(E)-[[(2Z)-2-cyclohexylimino)-4-methyl-1,3-thiazol-3(2H)-yl]imino]methyl]benzene-1,2,3-triol
Biological Activity
MIM1 is an inhibitor of Mcl-1. Inhibits Mcl-1 indirectly by induction of the proapoptotic Mcl-1 ligand NOXA via the unfolded protein response (UPR) pathway. Sensitizes leukemia cells to the Bcl-2 inhibitor venetoclax (ABT-199). Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.
Cohen et al.
Chem.Biol., 2012;19:1175 -
Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477.
Mallick et al.
Cell Death Dis., 2019;10:185
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Citation for MIM1
The citations listed below are publications that use Tocris products. Selected citations for MIM1 include:
1 Citation: Showing 1 - 1
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The androgen receptor mediates antiapoptotic function in myometrial cells.
Authors: Li Et al.
Autophagy 2014;5:e1338
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