Chemical Name: 4-(E)-[[(2Z)-2-cyclohexylimino)-4-methyl-1,3-thiazol-3(2H)-yl]imino]methyl]benzene-1,2,3-triol
Biological ActivityInhibitor of Mcl-1; selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro.
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A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.
Cohen et al.
Citation for MIM1
The citations listed below are publications that use Tocris products. Selected citations for MIM1 include:
1 Citation: Showing 1 - 1
The androgen receptor mediates antiapoptotic function in myometrial cells.
Authors: Li Et al.
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