Catalog Number: 0955
Chemical Name: (5R,10S)-(-)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cylcohepten-5,10-imine maleate
Biological Activity
Less active enantiomer (10-fold less potent in behavioral studies) than (+)-MK 801 maleate (Cat. No. 0924).
Technical Data
  • M.Wt:
    337.37
  • Formula:
    C16H15N.C4H4O4
  • Solubility:
    Soluble to 25 mM in water with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    121917-57-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Effects of MK-801 stereoisomers on schedule-controlled behavior in rats.
    Genovese and Lu
    Psychopharmacology., 1991;105:477
  2. Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-Methyl-D-aspartate antagonists.
    Thompson et al.
    J.Med.Chem., 1990;33:789
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (-)-MK 801 maleate include:

2 Citations: Showing 1 - 2
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  1. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
    Authors: Yang Et al.
    J Pharmacol Exp Ther 2005;25:4288
  2. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
    Authors: Huang Et al.
    J Neurosci 2004;24:4551

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