Potent, synthetic, cytotoxic analog of dolastatin 10
(Cat. No. 3375). Suppresses tumor cell viability in vitro
values are 0.22, 0.49 and 0.54 nM in BT474, MDA-MB-361-DYT2 and N87 cells, respectively). MMAE derivatives have been shown to induce regression of established tumor xenografts when conjugated to tumor targeting antibodies via a protease-cleavable linker.
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Development of potent monoclonal antibody auristatin conjugates for cancer therapy.
Doronina et al.
Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
Maderna et al.