Mouse Carboxypeptidase A1/CPA1 Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (9)
Supplemental Products

Mouse Carboxypeptidase A1/CPA1 Antibody Summary

Species Reactivity
Detects mouse Carboxypeptidase A1/CPA1 in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant human (rh) CPA1 is observed and approximately 10% cross-reactivity with rhCPA2, rhCPB1, and recombinant mouse CPA4 is observed.
Polyclonal Goat IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant mouse Carboxypeptidase A1/CPA1
Accession # Q7TPZ8
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Mouse Carboxypeptidase A1/CPA1 (Catalog # 2765-ZN)
25 µg/mL
Conditioned cell culture medium spiked with Recombinant Mouse Carboxypeptidase A1/CPA1 (Catalog # 2765-ZN), see our available Western blot detection antibodies
Measured by its ability to neutralize Recombinant Mouse Carboxypeptidase A1/CPA1 (0.25 µg/mL, Catalog # 2765‑ZN) cleavage of the fluorogenic peptide substrate Ac-Phe-Thiaphe-OH (100 µM). The Neutralization Dose (ND50) is typically 2 µg/mL.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Carboxypeptidase A1/CPA1

Carboxypeptidase A1 encoded by the CPA1 gene cleaves the C-terminal amide or ester bond of peptides that have a free C-terminal carboxyl group (1). It prefers the C-terminal residues with aromatic or branched aliphatic side chains including Phe, Tyr, Trp, Leu or Ile. It is important in the degradation of food proteins to produce essential amino acids such as Phe and Trp. The deduced amino acid sequence of mouse CPA1 consists of a signal peptide (residues 1 to 16), a pro region (residue 17 to 110), and a mature chain (residues 111 to 419). The purified recombinant CPA1 corresponds to the pro form, which can be activated and assayed.

  1. Auld, D.S. (2004) in Handbook of Proteolytic Enzymes (ed. Barrett, et al.) p. 812  Academic Press, San Diego.
Entrez Gene IDs
1357 (Human); 109697 (Mouse)
Alternate Names
carboxypeptidase A1 (pancreatic); Carboxypeptidase A1; CPA; CPA1; EC 3.4.17; EC

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Citations for Mouse Carboxypeptidase A1/CPA1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

9 Citations: Showing 1 - 9
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  1. Identification of Novel Ligands for Targeted Antifibrotic Therapy of Chronic Pancreatitis
    Authors: J Hung, R Awasthi, AL Klibanov, KA Kelly
    International Journal of Nanomedicine, 2021;16(0):5495-5512.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  2. A gene-environment-induced epigenetic program initiates tumorigenesis
    Authors: D Alonso-Cur, YJ Ho, C Burdziak, JLV Maag, JP Morris, R Chandwani, HA Chen, KM Tsanov, FM Barriga, W Luan, N Tasdemir, G Livshits, E Azizi, J Chun, JE Wilkinson, L Mazutis, SD Leach, R Koche, D Pe'er, SW Lowe
    Nature, 2021;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  3. Desmoplasia and oncogene driven acinar-to-ductal metaplasia are concurrent events during acinar cell-derived pancreatic cancer initiation in young adult mice
    Authors: BL Johnson, M d'Alincour, S Mackenzie-, M D'Apuzzo, HP Shih, ER Manuel, DJ Diamond
    PLoS ONE, 2019;14(9):e0221810.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  4. The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice
    Authors: CC Young, RM Baker, CJ Howlett, T Hryciw, JE Herman, D Higgs, R Gibbons, H Crawford, A Brown, CL Pin
    Cell Mol Gastroenterol Hepatol, 2019;7(1):93-113.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  5. SEC23B is required for pancreatic acinar cell function in adult mice
    Authors: R Khoriaty, N Vogel, MJ Hoenerhoff, MD Sans, G Zhu, L Everett, B Nelson, H Durairaj, B McKnight, B Zhang, SA Ernst, D Ginsburg, JA Williams
    Mol. Biol. Cell, 2017;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  6. Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors
    Authors: NAJ Krentz, D van Hoof, Z Li, A Watanabe, M Tang, C Nian, MS German, FC Lynn
    Dev. Cell, 2017;41(2):129-142.e6.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  7. Rab27A Is Present in Mouse Pancreatic Acinar Cells and Is Required for Digestive Enzyme Secretion.
    Authors: Hou Y, Ernst S, Stuenkel E, Lentz S, Williams J
    PLoS ONE, 2015;10(5):e0125596.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  8. A modular and flexible ESC-based mouse model of pancreatic cancer.
    Authors: Saborowski, Michael, Saborowski, Anna, Morris, John P 4, Bosbach, Benedikt, Dow, Lukas E, Pelletier, Jerry, Klimstra, David S, Lowe, Scott W
    Genes Dev, 2014;28(1):85-97.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  9. Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas.
    Authors: Kopinke D, Brailsford M, Shea JE, Leavitt R, Scaife CL, Murtaugh LC
    Development, 2011;138(3):431-41.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P


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