Mouse Cardiotrophin-1/CT-1 Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (3)
Supplemental Products

Mouse Cardiotrophin-1/CT-1 Antibody Summary

Species Reactivity
Detects mouse Cardiotrophin-1 in ELISAs and Western blots. In ELISAs, this antibody shows approximately 20% cross-reactivity with recombinant human (rh) Cardiotrophin‑1 and no cross-reactivity with rmIL-11, rmIL-6, rrCNTF, rmLIF, or rmOSM.
Monoclonal Rat IgG1 Clone # 91907
Protein A or G purified from hybridoma culture supernatant
E. coli-derived recombinant mouse Cardiotrophin-1
Accession # Q60753
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
1 µg/mL
Recombinant Mouse Cardiotrophin‑1/CT‑1 (Catalog # 438-CT)

Mouse Cardiotrophin-1/CT-1 Sandwich Immunoassay

Recommended Concentration
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: Mouse Cardiotrophin‑1/CT‑1 Biotinylated Antibody (Catalog # BAF438)

Standard: Recombinant Mouse Cardiotrophin-1/CT-1 Protein (Catalog # 438-CT)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Cardiotrophin-1/CT-1

Cardiotrophin-1 (CT-1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. CT-1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL-6 family members on a variety of cell types. Mouse CT-1 encodes a 203 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. The mechanism of CT-1 release from cells is currently not understood. Human and mouse CT-1 share 80% aa sequence identity and exhibit cross-species activity. CT-1 is highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels of CT-1 expression is also seen in testis and brain. CT-1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor beta subunit. A third alpha receptor subunit has also been implicated in the receptor complex.

  1. Pennica, D. et al. (1996) Cytokine and Growth Factor Reviews 7:81.
  2. Robledo, O. et al. (1997) J. Biol. Chem. 272:4855.
Entrez Gene IDs
1489 (Human); 13019 (Mouse)
Alternate Names
cardiophin 1; cardiotrophin 1; Cardiotrophin1; Cardiotrophin-1; CT-1CT1; CTF1

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Citations for Mouse Cardiotrophin-1/CT-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Preventive Effect of Cardiotrophin-1 Administration before DSS-Induced Ulcerative Colitis in Mice
    Authors: AI Sánchez-Ga, V Prieto-Vic, V Blanco-Goz, M Arévalo, Y Quiros, D López-Mont, FJ López-Hern, A Rodríguez-, JM López-Novo
    J Clin Med, 2019;8(12):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  2. Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling.
    Authors: Walker EC, McGregor NE, Poulton IJ, Pompolo S, Allan EH, Quinn JM, Gillespie MT, Martin TJ, Sims NA
    J. Bone Miner. Res., 2008;23(12):2025-32.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  3. Role of interleukin-6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation.
    Authors: Fredj S, Bescond J, Louault C, Delwail A, Potreau D
    J. Cell. Physiol., 2005;204(2):428-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC


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