Mouse CD161/NK1.1 APC-conjugated Antibody

Catalog #: FAB76141A Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
Detection of CD161/NK1.1 in Mouse Splenocytes by Flow Cytometry.
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Mouse CD161/NK1.1 APC-conjugated Antibody Summary

Species Reactivity
Detects mouse CD161/NK1.1 in Flow Cytometry.
Monoclonal Mouse IgG2A Clone # PK136
Protein A or G purified from hybridoma culture supernatant
NK-1+ cells from mouse spleen and bone marrow
Accession # AAH61168
Supplied in a saline solution containing BSA and Sodium Azide.
Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)


Recommended Concentration
Flow Cytometry
0.25-1 µg/106 cells
C57BL/6 splenocytes

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of CD161/NK1.1 antibody in Mouse Splenocytes antibody by Flow Cytometry. View Larger

Detection of CD161/NK1.1 in Mouse Splenocytes by Flow Cytometry. Mouse C57BL/6 splenocytes were stained with (A) Mouse Anti-Mouse CD161/NK1.1 APC-conjugated Monoclonal Antibody (Catalog # FAB76141A) or (B) Mouse IgG2A Isotype Control (IC003A) and Rat Anti-Mouse NKp46/NCR1 PE-conjugated Monoclonal Antibody (FAB22252P). Staining was performed using our Staining Membrane-associated Proteins protocol.

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Preparation and Storage

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CD161/NK1.1

NK-1.1 surface antigen is encoded by the NKR-P1B/NKR-P1C gene, also known as CD161b/CD161c and Ly-55. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN- gamma production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers. The PK136 antibody has been reported to deplete NK cells, induce redirected lysis, block NK cell function, and induce NK cell proliferation.

Entrez Gene IDs
17059 (Mouse)
Alternate Names
CD161 antigen; CD161; CD161/NK1.1; CD161c; CLEC5BC-type lectin domain family 5 member B; HNKR-P1a; killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B, member 1; Klrb1c; Ly55c; Ly-59; Natural killer cell surface protein P1A; NKR-P1; NKR-P1AMGC138614; NKRP1ANKR

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