Mouse CXCL15/Lungkine Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (2)
Supplemental Products

Mouse CXCL15/Lungkine Antibody Summary

Species Reactivity
Detects mouse CXCL15/Lungkine in ELISAs and Western blots. In sandwich immunoassays, no cross-reactivity or interference with recombinant mouse (rm) CXCL13, recombinant human (rh) CXCL13, rhCXCL5, rhCXCL8, rmMIP-2, recombinant rat CINC-2 beta, rmCX3CL1, rmCCL12, or rhCCL15 is observed.
Monoclonal Rat IgG2B Clone # 96708
Protein A or G purified from hybridoma culture supernatant
E. coli-derived recombinant mouse CXCL15/Lungkine
Accession # Q9WVL7
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
1 µg/mL
Recombinant Mouse CXCL15/Lungkine (Catalog # 442-LK)

Mouse CXCL15/Lungkine Sandwich Immunoassay

Recommended Concentration
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: Mouse CXCL15/Lungkine Biotinylated Antibody (Catalog # BAF442)

Standard: Recombinant Mouse CXCL15/Lungkine Protein (Catalog # 442-LK)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CXCL15/Lungkine

Mouse Lungkine/CXCL15 (1), also named WECHE (2), is a member of the ELR motif-containing CXC chemokines. The cDNA of mouse Lungkine encodes a protein of 166 amino acids (aa) with a 25 aa predicted signal peptide and a 141 aa mature protein with an extremely long C‑terminal tail that protrudes beyond the chemokine fold. Mouse Lungkine shares 35% aa sequence identity with human CXCL5 and 31% identity with human CXCL8. The gene for mouse Lungkine has been mapped to chromosome 5. By Northern blot and in situ hybridization, Lungkine transcripts are only specifically detected in the adult and fetal lung, and its expression is up‑regulated under inflammatory conditions (1). Lungkine protein is secreted into bronchoalveolar space and is involved in lung-specific neutrophils trafficking (1). Studies from Lungkine knock out mice suggests that Lungkine is an important mediator of neutrophil migration from the lung parenchyma into the airspace (3). Lungkine is also chemotactic for bone marrow progenitor cells and modulates hematopoietic cell differentiation (2).

  1. Rossi, D.L. et al. (1999) J. Immunol. 162:5490.
  2. Ohneda, O. et al. (2000) Immunity 12:141.
  3. Chen, S-C. et al. (2001) J. Immunol. 166:3362.
Entrez Gene IDs
20309 (Mouse)
Alternate Names
CXCL15; Il8; IL-8; Lungkine; Scyb15; Weche

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Citations for Mouse CXCL15/Lungkine Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Invariant Natural Killer T Cells Play a Role in Chemotaxis, Complement Activation and Mucus Production in a Mouse Model of Airway Hyperreactivity and Inflammation.
    Authors: Karisola P, Lehto M, Kinaret P, Ahonen N, Haapakoski R, Anthoni M, Taniguchi M, Wolff H, Puustinen A, Alenius H
    PLoS ONE, 2015;10(6):e0129446.
    Species: Mouse
    Sample Types: BALF
    Applications: Western Blot
  2. Circulating CXC-chemokine concentrations in a murine intestinal ischemia-reperfusion model.
    Authors: Maheshwari A, Christensen RD, Calhoun DA
    Fetal Pediatr Pathol, 2004;23(2):145-57.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Development


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