Mouse CXCL15/Lungkine Antibody
Mouse CXCL15/Lungkine Antibody Summary
Accession # Q9WVL7
Mouse CXCL15/Lungkine Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Mouse Lungkine/CXCL15 (1), also named WECHE (2), is a member of the ELR motif-containing CXC chemokines. The cDNA of mouse Lungkine encodes a protein of 166 amino acids (aa) with a 25 aa predicted signal peptide and a 141 aa mature protein with an extremely long C‑terminal tail that protrudes beyond the chemokine fold. Mouse Lungkine shares 35% aa sequence identity with human CXCL5 and 31% identity with human CXCL8. The gene for mouse Lungkine has been mapped to chromosome 5. By Northern blot and in situ hybridization, Lungkine transcripts are only specifically detected in the adult and fetal lung, and its expression is up‑regulated under inflammatory conditions (1). Lungkine protein is secreted into bronchoalveolar space and is involved in lung-specific neutrophils trafficking (1). Studies from Lungkine knock out mice suggests that Lungkine is an important mediator of neutrophil migration from the lung parenchyma into the airspace (3). Lungkine is also chemotactic for bone marrow progenitor cells and modulates hematopoietic cell differentiation (2).
Citations for Mouse CXCL15/Lungkine Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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Invariant Natural Killer T Cells Play a Role in Chemotaxis, Complement Activation and Mucus Production in a Mouse Model of Airway Hyperreactivity and Inflammation.
Authors: Karisola P, Lehto M, Kinaret P, Ahonen N, Haapakoski R, Anthoni M, Taniguchi M, Wolff H, Puustinen A, Alenius H
PLoS ONE, 2015;10(6):e0129446.
Sample Types: BALF
Applications: Western Blot
Circulating CXC-chemokine concentrations in a murine intestinal ischemia-reperfusion model.
Authors: Maheshwari A, Christensen RD, Calhoun DA
Fetal Pediatr Pathol, 2004;23(2):145-57.
Sample Types: Serum
Applications: ELISA Development
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