Mouse Epiregulin Biotinylated Antibody

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Product Details
Supplemental Products

Mouse Epiregulin Biotinylated Antibody Summary

Species Reactivity
Detects mouse Epiregulin in ELISAs and Western blots. In sandwich immunoassays, approximately 1% cross-reactivity with recombinant human (rh) Epiregulin is observed and less than 0.3% cross-reactivity with recombinant mouse (rm) Amphiregulin, rmBetacellulin, rmEGF and rhHeregulin is observed.
Polyclonal Goat IgG
Antigen Affinity-purified
E. coli-derived recombinant mouse Epiregulin (R&D Systems, Catalog # 1068-EP)
Accession # NP_031976
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Mouse Epiregulin (Catalog # 1068-EP)

Mouse Epiregulin Sandwich Immunoassay

Recommended Concentration
ELISA Detection (Matched Antibody Pair)
0.1-0.4 µg/mL 

Use in combination with:

Capture Reagent: Mouse Epiregulin Antibody (Catalog # MAB1068)

Standard: Recombinant Mouse Epiregulin Protein (Catalog # 1068-EP)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Epiregulin

Epiregulin is a member of the EGF family of growth factors which includes, among others, epidermal growth factor (EGF), transforming growth factor (TGF)-alpha, amphiregulin (ARG), HB (heparin-binding)-EGF, betacellulin, and the various heregulins. They are all synthesized as transmembrane precursors and converted to soluble forms by proteolytic cleavage. Epiregulin was originally purified from the mouse fibroblast-derived tumor cell line NIH3T3/T7 (1). The mouse Epiregulin cDNA encodes for a transmembrane precursor of 162 amino acid in length, with the mature soluble form comprising residues 56‑101 (2). The mode of action of Epiregulin is similar to other EGF family members in that it binds to and activates the tyrosine-kinase, ErbB-family receptors (ErbB1 through B4) (3). Although it stimulates phosphorylation of all four receptors, it appears to interact primarily with ErbB1 and ErbB4. Epiregulin has the broadest specificity of the EGF-like ligands but seems to preferentially activate heterodimeric receptor complexes (4). Epiregulin exhibits a variety of biological effects. It was originally shown to both inhibit growth of several epithelial tumor cells and stimulate growth of fibroblasts and other types of cells (1). Epiregulin expression is upregulated in a number of carcinoma cell lines. It has also been shown to be an autocrine growth factor in human epidermal keratinocytes (5). Epiregulin has also been shown to play a role in the early steps of pregnancy, regulating attachment of the blastocyst to the uterine epithelium during the implantation process (6).

  1. Toyoda, H. et al. (1995) J. Biol. Chem. 270:7495.
  2. Toyoda, H. et al. (1995) FEBS Lett. 377:403.
  3. Komurasaki, T. et al. (1997) Oncogene 15:2841.
  4. Shelly, M. et al. (1998) J. Biol. Chem. 273:10496.
  5. Shirakata, Y. et al. (2000) J. Biol. Chem. 275:5748.
  6. Das, S.K. et al. (1997) Dev. Biol. 190:178.
Entrez Gene IDs
2069 (Human); 13874 (Mouse)
Alternate Names
Epiregulin; ER; EREG; proepiregulin

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