Mouse Gas6 Biotinylated Antibody
Mouse Gas6 Biotinylated Antibody Summary
Accession # CAA42507
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Mouse Gas6 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Growth arrest-specific gene 6 (Gas6) was initially characterized as a gene whose expression was up-regulated in serum starved NIH 3T3 fibroblasts and whose expression is down-regulated during growth induction. Mouse Gas6 is a 673 amino acid protein that shares 81% identity to its human homolog. Gas6 is a member of the vitamin K-dependent family of proteins that includes human protein S, a negative coregulator in the blood coagulation pathway. Gas6 and protein S share structural motifs that characterize this family: an extensively gamma -carboxylated amino terminus (Gla domain), four EGF-like repeats, and a carboxy terminus containing globular (G) domains with homology to steroid hormone-binding globulin. It is a ligand for the Axl (Ufo/Ark), Sky (Dtk/Tyro3/Rse/Brt/Tif), and Mer (Eyk) families of tyrosine kinase receptors. Gas6 binds to these receptors via tandem G domains at its C-terminus. Gas6 is ubiquitously expressed, but most abundantly in lung, intestine, bone marrow and endothelium.
Gas6 has been implicated in a variety of biological processes. It serves as a mitogen for fibroblasts, endothelial cells, neural cells, vascular smooth muscle cells and several tumor-derived cell lines. In addition, Gas6 prevents apoptosis, independent of its mitogenic activity. Gas6 is capable of inducing cell adhesion and chemotaxis in specific cell types. It also supports vitamin K-independent hematopoiesis when expressed by stromal cells. Gas6 signal transduction following Axl/Sky/Mer receptor activation has been reported to occur through such diverse signaling pathways as PI3K, MAP kinase, Src, Ras and beta -catenin.
- Manfioletti, G. et al. (1993) Mol. Cell Biol. 13:4976.
- Goruppi, S. et al. (1996) Oncogene 12:471.
- Crosier, K and P. Crosier (1997) Pathology 29:131.
- Dormady, S. et al. (2000) Proc. Natl. Acad. Sci. USA 97:12260.
- Goruppi, S. et al. (2001) Mol. Cell Biol. 21:902.
Citations for Mouse Gas6 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 3
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Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies
Authors: Mihalis S Kariolis
J. Clin. Invest, 2016;0(0):.
Sample Types: Serum
Applications: ELISA Development (Detection)
Role of Gas6 in erythropoiesis and anemia in mice.
Authors: Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish RJ, Tjwa M, Plaisance S, Sugamele R, DeMol M, Martinez-Soria E, Maxwell PH, Lemke G, Goff SP, Matsushima GK, Earp HS, Chanson M, Collen D, Izui S, Schapira M, Conway EM, Carmeliet P
J. Clin. Invest., 2008;118(2):583-96.
Sample Types: Cell Culture Supernates
Applications: ELISA Development
The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung.
Authors: Fujimori T, Grabiec A, Kaur M, Bell T, Fujino N, Cook P, Svedberg F, MacDonald A, Maciewicz R, Singh D, Hussell T
Mucosal Immunol, 0;8(5):1021-30.
Sample Types: BALF
Applications: Flow Cytometry
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