Mouse IGFBP-L1 Antibody
Mouse IGFBP-L1 Antibody Summary
Accession # Q80W15
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Insulin-like Growth Factor Binding Protein-Like 1 (IGFBP‑L1), also known as IGFBP-rP4, is a 38 kDa secreted member of the IGFBP superfamily of proteins. IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins (1). IGFBP-L1 contains an N-terminal IGFBP motif, a Kazal-type serine protease inhibitor region, and a C‑terminal Ig-like domain (2, 3). Mature mouse IGFBP-L1 shares 76% and 96% amino acid (aa) sequence identity with human and rat IGFBP-L1, respectively. It shares 38%-41% aa sequence identity with mouse IGFBP-7 and IGFBP-rp10 and 20%‑24% aa sequence identity with mouse IGFBP-1, -2, -3, -4, -5, and -6. IGFBP-L1 is most highly expressed in testis and brain, while lower levels are more broadly expressed (3). IGFBP-L1 is expressed in regionally and temporally distinct patterns during forebrain development (4). IGFBP-L1 inhibits cell proliferation in vitro and is downregulated in many colon and lung tumors (3). Transcriptional downregulation by promoter methylation is predictive of breast cancer aggressiveness (5).
- Firth, S.M. and R.C. Baxter (2002) Endocr. Rev. 23:824.
- Accession # Q80W15.
- Cai, Z. et al. (2005) Biochem. Biophys. Res. Commun. 331:261.
- Gonda, Y. et al. (2007) Gene Expr. Patterns 7:431.
- Smith, P. et al. (2007) Clin. Cancer Res. 13:4061.
Citation for Mouse IGFBP-L1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
IGFBPL1 Regulates Axon Growth through IGF-1-mediated Signaling Cascades
Authors: C Guo, KS Cho, Y Li, K Tchedre, C Antolik, J Ma, J Chew, TP Utheim, XA Huang, H Yu, MTA Malik, N Anzak, DF Chen
Sci Rep, 2018;8(1):2054.
Sample Types: Whole Tissue
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