Mouse IL-13 Culture Media Quantikine ELISA M1300CB: R&D Systems

Mouse IL-13 Culture Media Quantikine ELISA

(103 citations)
(1 Review)
  
  • Assay Length
    4.5 hours
  • Sample Type & Volume Required Per Well
    Cell Culture Supernates (50 uL)
  • Sensitivity
    1.5 pg/mL
  • Assay Range
    7.8 - 500 pg/mL (Cell Culture Supernates)
  • Specificity
    Natural and recombinant mouse IL-13
  • Cross-reactivity
    < 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
  • Interference
    No significant interference observed with available related molecules.
Product Summary
The Quantikine Mouse IL-13 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-13 levels in cell culture supernates. It contains E. coli-expressed recombinant mouse IL-13 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse IL-13 accurately. Results obtained using natural mouse IL-13 showed dose curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-13.

Precision
Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision.
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
Cell Culture Supernates
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020202020
Mean33.910043231.693.4405
Standard Deviation1.12.711.22.57.217.7
CV%3.22.72.67.97.74.4

Recovery

The recovery of mouse IL-13 spiked to levels throughout the range of the assay was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Supernates (n=13) 99 89-119
Linearity
To assess the linearity of the assay, samples containing and/or spiked with mouse IL-13 were diluted with Calibrator Diluent and assayed.
Mouse IL-13 Culture Media Quantikine ELISA
Preparation and Storage
  • Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: IL-13
IL-13 (Interleukin-13) plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances by macrophages, fibroblasts, and endothelial cells. It promotes B cell activation, immunoglobulin class switching to IgE, and the upregulation of CD23/Fc epsilon RII. IL-13 signals through a receptor complex containing IL-13 R alpha 1 and IL-4 R alpha. This complex also functions as the type 2 IL-4 receptor. IL-13 R alpha 2 binds IL-13 and prevents IL-13 from signaling through the IL-13 R alpha 1/IL-4 R alpha complex. IL-13-bound IL-13 R alpha 2 can directly promote tumor cell invasiveness and the development of tissue fibrosis.
    • Long Name
      Interleukin 13
    • Entrez Gene IDs
      3596 (Human); 16163 (Mouse); 116553 (Rat); 574325 (Primate);
    • Alternate Names
      ALRHMGC116789; BHR1interleukin-13; IL13; IL-13; IL-13MGC116788; interleukin 13; MGC116786; NC30; P600;
    Related Research Areas
    Assay Procedure
    Refer to the product for complete assay procedure.

    Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
    1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
    2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.

    3. 50 µL Assay Diluent
    4.   Add 50 µL of Assay Diluent to each well.

    5. 50 µL Standard, Control, or Sample
    6.   Add 50 µL of Standard, Control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
    7.   Aspirate each well and wash, repeating the process 4 times for a total of 5 washes.

    8. 100 µL Conjugate
    9.   Add 100 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
    10.   Aspirate and wash 5 times.

    11. 100 µL Substrate Solution
    12.   Add 100 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.

    13. 100 µL Stop Solution
    14.   Add 100 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.
    Citations:

    R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

    103 Citations: Showing 1 - 10
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    Species
    Sample Type
    1. STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection
      Authors: MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles
      J. Immunol., 2017;0(0):.
      Species: Mouse
      Sample Type: Tissue Homogenates
    2. Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine
      Authors: YT Lee, CT Wu, HL Sun, JL Ko, KH Lue
      J Microbiol Immunol Infect, 2017;0(0):.
      Species: Mouse
      Sample Type: BALF
    3. Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma
      Authors: U Fujii, N Miyahara, A Taniguchi, N Oda, D Morichika, E Murakami, H Nakayama, K Waseda, M Kataoka, H Kakuta, M Tanimoto, A Kanehiro
      Respir. Res, 2017;18(1):23.
      Species: Mouse
      Sample Type: BALF
    4. Increased mitochondrial arginine metabolism supports bioenergetics in asthma
      J Clin Invest, 2016;0(0):.
      Species: Mouse
      Sample Type: BALF
    5. NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
      Sci Rep, 2016;6(0):39075.
      Species: Mouse
      Sample Type: Tissue Homogenates
    6. NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
      Sci Rep, 2016;6(0):39075.
      Species: Mouse
      Sample Type: Tissue Homogenates
    7. Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma
      EBioMedicine, 2016;0(0):.
      Species: Mouse
      Sample Type: Tissue Homogenates
    8. PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells.
      Authors: Yashiro T, Kubo M, Ogawa H, Okumura K, Nishiyama C
      PLoS ONE, 2015;10(9):e0137699.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    9. G-protein-coupled estrogen receptor agonist suppresses airway inflammation in a mouse model of asthma through IL-10.
      Authors: Itoga M, Konno Y, Moritoki Y, Saito Y, Ito W, Tamaki M, Kobayashi Y, Kayaba H, Kikuchi Y, Chihara J, Takeda M, Ueki S, Hirokawa M
      PLoS ONE, 2015;10(3):e0123210.
      Species: Mouse
      Sample Type: BALF
    10. Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase.
      Authors: Mishra, Amarjit, Brown, Alexandr, Yao, Xianglan, Yang, Shutong, Park, Sung-Jun, Liu, Chengyu, Dagur, Pradeep, McCoy, J Philip, Keeran, Karen J, Nugent, Gayle Z, Jeffries, Kenneth, Qu, Xuan, Yu, Zu-Xi, Levine, Stewart, Chung, Jay H
      Nat Commun, 2015;6(0):6224.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    11. STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.
      Authors: Dulek D, Newcomb D, Toki S, Goliniewska K, Cephus J, Reiss S, Bates J, Crowe J, Boyd K, Moore M, Zhou W, Peebles R
      J Virol, 2014;88(17):9655-72.
      Species: Mouse
      Sample Type: Tissue Homogenates
    12. Impact of ozone exposure on the response to glucocorticoid in a mouse model of asthma: involvements of p38 MAPK and MKP-1.
      Authors: Bao, Aihua, Li, Feng, Zhang, Min, Chen, Yuqing, Zhang, Pengyu, Zhou, Xin
      Respir Res, 2014;15(0):126.
      Species: Mouse
      Sample Type: BALF
    13. Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response.
      Authors: Gupta P, Giri J, Srivastav S, Chande A, Mukhopadhyaya R, Das P, Ukil A
      FASEB J, 2014;28(4):1756-68.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    14. Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.
      Authors: Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C
      J Immunol, 2014;192(8):3569-81.
      Species: Mouse
      Sample Type: Tissue Homogenates
    15. Genetic vaccine for respiratory syncytial virus provides protection without disease potentiation.
      Authors: Johnson T, Rangel D, Graham B, Brough D, Gall J
      Mol Ther, 2014;22(1):196-205.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    16. Induction of the specific allergic immune response is independent of proteases from the fungus Alternaria alternata.
      Authors: Denis O, Vincent M, Havaux X, De Prins S, Treutens G, Huygen K
      Eur J Immunol, 2013;43(4):907-17.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    17. Antibody to mCLCA3 suppresses symptoms in a mouse model of asthma.
      Authors: Song L, Liu D, Wu C, Wu S, Yang J, Ren F, Li Y
      PLoS ONE, 2013;8(12):e82367.
      Species: Mouse
      Sample Type: BALF
    18. Monocyte-derived dendritic cell recruitment and allergic T(H)2 responses after exposure to diesel particles are CCR2 dependent.
      Authors: Provoost S, Maes T, Joos GF, Tournoy KG
      J. Allergy Clin. Immunol., 2012;129(2):483-91.
      Species: Mouse
      Sample Type: BALF
    19. TLR-mediated distinct IFN-gamma/IL-10 pattern induces protective immunity against murine visceral leishmaniasis.
      Eur. J. Immunol., 2012;42(8):2087-99.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    20. Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor.
      J. Exp. Med., 2012;209(8):1493-503.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    21. Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
      Authors: Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
      Am. J. Pathol., 2012;179(1):302-14.
      Species: Mouse
      Sample Type: Tissue Homogenates
    22. IL-33-activated dendritic cells are critical for allergic airway inflammation.
      Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
      Eur. J. Immunol., 2011;41(6):1675-86.
      Species: Mouse
      Sample Type: BALF
    23. Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.
      Authors: Louten J, Rankin AL, Li Y
      Int. Immunol., 2011;23(5):307-15.
      Species: Mouse
      Sample Type: BALF
    24. Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference.
      Authors: Sang W, Zhou C, Cheng N, Li Z, Zeng L, Xu K
      Immunol. Lett., 2011;136(2):194-202.
      Species: Mouse
      Sample Type: Plasma
    25. Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts.
      Authors: Asquith KL, Horvat JC, Kaiko GE
      PLoS Pathog., 2011;7(5):e1001339.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    26. The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling.
      Authors: Doherty TA, Soroosh P, Khorram N, Fukuyama S, Rosenthal P, Cho JY, Norris PS, Choi H, Scheu S, Pfeffer K, Zuraw BL, Ware CF, Broide DH, Croft M
      Nat. Med., 2011;17(5):596-603.
      Species: Mouse
      Sample Type: Tissue Homogenates
    27. The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines.
      Authors: Vultaggio A, Nencini F, Pratesi S, Maggi L, Guarna A, Annunziato F, Romagnani S, Parronchi P, Maggi E
      J. Immunol., 2011;186(8):4707-15.
      Species: Mouse
      Sample Type: Serum
    28. Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma.
      Authors: Hirata H, Arima M, Fukushima Y, Honda K, Sugiyama K, Tokuhisa T, Fukuda T
      Clin. Exp. Allergy, 2011;41(8):1133-42.
      Species: Mouse
      Sample Type: BALF
    29. Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity.
      Authors: Barlow JL, Flynn RJ, Ballantyne SJ, McKenzie AN
      Clin. Exp. Allergy, 2011;41(10):1447-55.
      Species: Mouse
      Sample Type: BALF
    30. IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
      Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
      J. Immunol., 2011;188(3):1503-13.
      Species: Mouse
      Sample Type: BALF
    31. IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease.
      Authors: Taube C, Tertilt C, Gyulveszi G, Dehzad N, Kreymborg K, Schneeweiss K, Michel E, Reuter S, Renauld JC, Arnold-Schild D, Schild H, Buhl R, Becher B
      PLoS ONE, 2011;6(7):e21799.
      Species: Mouse
      Sample Type: BALF
    32. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling.
      Authors: Graham BB, Mentink-Kane MM, El-Haddad H
      Am. J. Pathol., 2010;177(3):1549-61.
      Species: Mouse
      Sample Type: Tissue Homogenates
    33. Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice.
      Authors: Alm AS, Li K, Yang D, Andersson R, Lu Y, Wang X
      Cytokine, 2010;49(3):256-63.
      Species: Mouse
      Sample Type: BALF
    34. Anti-Asthma Simplified Herbal Medicine Intervention-induced long-lasting tolerance to allergen exposure in an asthma model is interferon-gamma, but not transforming growth factor-beta dependent.
      Authors: Srivastava K, Zhang T, Yang N, Sampson H, Li XM
      Clin. Exp. Allergy, 2010;40(11):1678-88.
      Species: Mouse
      Sample Type: BALF
    35. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
      Authors: Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, Bucks C, Kane CM, Fallon PG, Pannell R, Jolin HE, McKenzie AN
      Nature, 2010;464(7293):1367-70.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    36. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.
      Authors: Wright PL, Yu J, Di YP
      J. Exp. Med., 2010;207(12):2595-607.
      Species: Mouse
      Sample Type: BALF
    37. House dust mite induces direct airway inflammation in vivo: implications for future disease therapy?
      Authors: De Alba J, Raemdonck K, Dekkak A, Collins M, Wong S, Nials AT, Knowles RG, Belvisi MG, Birrell MA
      Eur. Respir. J., 2010;35(6):1377-87.
      Species: Mouse
      Sample Type: BALF
    38. Mucosal vaccination using claudin-4-targeting.
      Authors: Kakutani H, Kondoh M, Fukasaka M, Suzuki H, Hamakubo T, Yagi K
      Biomaterials, 2010;31(20):5463-71.
      Species: Mouse
      Sample Type: Serum
    39. Effects of a leukotriene B4 receptor antagonist on bleomycin-induced pulmonary fibrosis.
      Authors: Izumo T, Kondo M, Nagai A
      Eur. Respir. J., 2009;34(6):1444-51.
      Species: Mouse
      Sample Type: BALF
    40. Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model.
      Authors: Kim DY, Park JW, Jeoung D, Ro JY
      Eur. J. Pharmacol., 2009;612(1):98-105.
      Species: Mouse
      Sample Type: BALF
    41. Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation.
      Authors: Park SJ, Lee KS, Kim SR, Min KH, Choe YH, Moon H, Chae HJ, Yoo WH, Lee YC
      J. Immunol., 2009;183(5):3259-67.
      Species: Mouse
      Sample Type: BALF
    42. The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.
      Authors: Claudio E, Sonder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U
      J. Immunol., 2009;182(3):1617-30.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    43. Lovastatin inhibits antigen-induced airway eosinophilia without affecting the production of inflammatory mediators in mice.
      Authors: Chiba Y, Sato S, Misawa M
      Inflamm. Res., 2009;0(0):.
      Species: Mouse
      Sample Type: BALF
    44. TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity.
      Authors: Johnson TR, Rao S, Seder RA, Chen M, Graham BS
      Vaccine, 2009;27(23):3045-52.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    45. Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice.
      Authors: Mizutani N, Nabe T, Yoshino S
      J. Immunol., 2009;183(6):4039-46.
      Species: Mouse
      Sample Type: BALF
    46. Intranasal challenge with increasing ovalbumin doses differently affects airway hyperresponsiveness and inflammatory cell accumulation in mouse model of asthma.
      Authors: Bosnjak B, Ivetic Tkalcevic V, Duric K, Belamaric D, Cuzic S, Ferencic Z, Brajsa K, Glojnaric I, Antolovic R, Hrvacic B
      Inflamm. Res., 2009;58(11):773-81.
      Species: Mouse
      Sample Type: BALF
    47. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
      Authors: He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS
      J. Allergy Clin. Immunol., 2009;124(4):761-70.e1.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    48. Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production.
      Authors: Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD
      Inflamm. Res., 2009;58(12):845-54.
      Species: Mouse
      Sample Type: BALF
    49. A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice.
      Authors: Page K, Ledford JR, Zhou P, Wills-Karp M
      J. Immunol., 2009;183(5):3400-8.
      Species: Mouse
      Sample Type: Tissue Homogenates
    50. Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthma.
      Authors: Ryman-Rasmussen JP, Tewksbury EW, Moss OR, Cesta MF, Wong BA, Bonner JC
      Am. J. Respir. Cell Mol. Biol., 2009;40(3):349-58.
      Species: Mouse
      Sample Type: BALF
    51. A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice.
      Authors: Shinagawa K, Ploplis VA, Castellino FJ
      Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(5):L763-70.
      Species: Mouse
      Sample Type: BALF
    52. Macrophage migration inhibitory factor homologs of anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+CD25+Foxp3+ T cell recruitment.
      Authors: Park SK, Cho MK, Park HK, Lee KH, Lee SJ, Choi SH, Ock MS, Jeong HJ, Lee MH, Yu HS
      J. Immunol., 2009;182(11):6907-14.
      Species: Mouse
      Sample Type: BALF
    53. Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner.
      Authors: Kottyan LC, Collier AR, Cao KH, Niese KA, Hedgebeth M, Radu CG, Witte ON, Khurana Hershey GK, Rothenberg ME, Zimmermann N
      Blood, 2009;114(13):2774-82.
      Species: Mouse
      Sample Type: Cell Lysates
    54. Osteopontin deficiency protects against airway remodeling and hyperresponsiveness in chronic asthma.
      Authors: Simoes DC, Xanthou G, Petrochilou K, Panoutsakopoulou V, Roussos C, Gratziou C
      Am. J. Respir. Crit. Care Med., 2009;179(10):894-902.
      Species: Mouse
      Sample Type: Tissue Homogenates
    55. Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7.
      Authors: Vultaggio A, Nencini F, Fitch PM, Fili L, Maggi L, Fanti P, deVries A, Beccastrini E, Palandri F, Manuelli C, Bani D, Giudizi MG, Guarna A, Annunziato F, Romagnani S, Maggi E, Howie SE, Parronchi P
      J. Immunol., 2009;182(2):880-9.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    56. Temporal changes in myeloid cells in the cervix during pregnancy and parturition.
      Authors: Timmons BC, Fairhurst AM, Mahendroo MS
      J. Immunol., 2009;182(5):2700-7.
      Species: Mouse
      Sample Type: Tissue Homogenates
    57. CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling.
      Authors: Kearley J, Robinson DS, Lloyd CM
      J. Allergy Clin. Immunol., 2008;122(3):617-24.e6.
      Species: Mouse
      Sample Type: BALF
    58. Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis.
      Authors: Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ
      J. Immunol., 2008;181(2):1491-8.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    59. IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
      Authors: Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA
      J. Immunol., 2008;180(1):522-9.
      Species: Mouse
      Sample Type: BALF
    60. CD43 regulates Th2 differentiation and inflammation.
      Authors: Cannon JL, Collins A, Mody PD, Balachandran D, Henriksen KJ, Smith CE, Tong J, Clay BS, Miller SD, Sperling AI
      J. Immunol., 2008;180(11):7385-93.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    61. T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
      Authors: Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ
      Nature, 2008;455(7210):246-50.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    62. GS143, an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in mice.
      Authors: Hirose K, Wakashin H, Oki M, Kagami S, Suto A, Ikeda K, Watanabe N, Iwamoto I, Furuichi Y, Nakajima H
      Biochem. Biophys. Res. Commun., 2008;374(3):507-11.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    63. Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses.
      Authors: Zhou W, Newcomb DC, Moore ML, Goleniewska K, O'Neal JF, Peebles RS
      J. Immunol., 2008;181(8):5360-7.
      Species: Mouse
      Sample Type: Tissue Homogenates
    64. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
      Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
      Eur. J. Pharmacol., 2008;590(1):400-8.
      Species: Mouse
      Sample Type: Tissue Homogenates
    65. A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis.
      Authors: Trujillo G, O'Connor EC, Kunkel SL, Hogaboam CM
      Am. J. Pathol., 2008;172(5):1209-21.
      Species: Mouse
      Sample Type: Tissue Homogenates
    66. Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma.
      Authors: Therien AG, Bernier V, Weicker S, Tawa P, Falgueyret JP, Mathieu MC, Honsberger J, Pomerleau V, Robichaud A, Stocco R, Dufresne L, Houshyar H, Lafleur J, Ramachandran C, O'Neill GP, Slipetz D, Tan CM
      Am. J. Respir. Cell Mol. Biol., 2008;39(1):26-35.
      Species: Mouse
      Sample Type: BALF
    67. Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein.
      Authors: Johnson TR, Rothenberg ME, Graham BS
      J. Leukoc. Biol., 2008;84(3):748-59.
      Species: Mouse
      Sample Type: Tissue Homogenates
    68. Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity.
      Authors: Presser K, Schwinge D, Wegmann M, Huber S, Schmitt S, Quaas A, Maxeiner JH, Finotto S, Lohse AW, Blessing M, Schramm C
      J. Immunol., 2008;181(11):7751-8.
      Species: Mouse
      Sample Type: BALF
    69. Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells.
      Authors: Jacobsen EA, Ochkur SI, Pero RS, Taranova AG, Protheroe CA, Colbert DC, Lee NA, Lee JJ
      J. Exp. Med., 2008;205(3):699-710.
      Species: Mouse
      Sample Type: BALF
    70. Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis.
      Authors: Peng Z, Fernandez P, Wilder T, Yee H, Chiriboga L, Chan ES, Cronstein BN
      FASEB J., 2008;22(7):2263-72.
      Species: Mouse
      Sample Type: Tissue Homogenates
    71. FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.
      Authors: Daniel C, Sartory NA, Zahn N
      Mol. Immunol., 2007;44(13):3305-16.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    72. Prolonged inhaled allergen exposure can induce persistent tolerance.
      Authors: Van Hove CL, Maes T, Joos GF, Tournoy KG
      Am. J. Respir. Cell Mol. Biol., 2007;36(5):573-84.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    73. T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
      Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
      J. Allergy Clin. Immunol., 2007;119(3):662-70.
      Species: Mouse
      Sample Type: BALF
    74. Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma.
      Authors: Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR
      J. Immunol., 2007;178(10):6191-9.
      Species: Mouse
      Sample Type: BALF
    75. IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation.
      Authors: Yoshimoto T, Yoshimoto T, Yasuda K, Mizuguchi J, Nakanishi K
      J. Immunol., 2007;179(7):4415-23.
      Species: Mouse
      Sample Type: Serum
    76. B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma.
      Authors: Matsumoto K, Fukuyama S, Eguchi-Tsuda M, Nakano T, Matsumoto T, Matsumura M, Moriwaki A, Kan-o K, Wada Y, Yagita H, Shin T, Pardoll DM, Patcharee R, Azuma M, Nakanishi Y, Inoue H
      Biochem. Biophys. Res. Commun., 2007;365(1):170-5.
      Species: Mouse
      Sample Type: BALF
    77. Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling.
      Authors: Denis O, van den Brule S, Heymans J, Havaux X, Rochard C, Huaux F, Huygen K
      Immunology, 2007;122(2):268-78.
      Species: Mouse
      Sample Type: BALF
    78. Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness.
      Authors: Levy BD, Kohli P, Gotlinger K, Haworth O, Hong S, Kazani S, Israel E, Haley KJ, Serhan CN
      J. Immunol., 2007;178(1):496-502.
      Species: Mouse
      Sample Type: BALF
    79. Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function.
      Authors: Pan PY, Wang GX, Yin B, Ozao J, Ku T, Divino CM, Chen SH
      Blood, 2007;111(1):219-28.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    80. Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia.
      Authors: Choo-Wing R, Nedrelow JH, Homer RJ, Elias JA, Bhandari V
      Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(1):L142-50.
      Species: Mouse
      Sample Type: Cell Lysates
    81. Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung.
      Authors: Oh SY, Zheng T, Bailey ML, Barber DL, Schroeder JT, Kim YK, Zhu Z
      J. Allergy Clin. Immunol., 2007;119(1):123-31.
      Species: Mouse
      Sample Type: BALF
    82. The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia.
      Authors: Kudlacz E, Conklyn M, Andresen C, Whitney-Pickett C, Changelian P
      Eur. J. Pharmacol., 2007;582(1):154-61.
      Species: Mouse
      Sample Type: BALF
    83. Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation.
      Authors: Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW
      J. Immunol., 2007;178(1):480-8.
      Species: Mouse
      Sample Type: BALF
    84. Modulation of airway remodeling and airway inflammation by peroxisome proliferator-activated receptor gamma in a murine model of toluene diisocyanate-induced asthma.
      Authors: Lee KS, Park SJ, Kim SR, Min KH, Jin SM, Lee HK, Lee YC
      J. Immunol., 2006;177(8):5248-57.
      Species: Mouse
      Sample Type: BALF
    85. Allergic airway inflammation inhibits pulmonary antibacterial host defense.
      Authors: Beisswenger C, Kandler K, Hess C, Garn H, Felgentreff K, Wegmann M, Renz H, Vogelmeier C, Bals R
      J. Immunol., 2006;177(3):1833-7.
      Species: Mouse
      Sample Type: BALF
    86. Persistent effects induced by IL-13 in the lung.
      Authors: Fulkerson PC, Fischetti CA, Hassman LM, Nikolaidis NM, Rothenberg ME
      Am. J. Respir. Cell Mol. Biol., 2006;35(3):337-46.
      Species: Mouse
      Sample Type: BALF
    87. Obligatory role for interleukin-13 in obstructive lesion development in airway allografts.
      Authors: Lama VN, Harada H, Badri LN, Flint A, Hogaboam CM, McKenzie A, Martinez FJ, Toews GB, Moore BB, Pinsky DJ
      Am. J. Pathol., 2006;169(1):47-60.
      Species: Mouse
      Sample Type: Tissue Homogenates
    88. Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissues.
      Authors: Alvarez D, Swirski FK, Yang TC, Fattouh R, Croitoru K, Bramson JL, Stampfli MR, Jordana M
      J. Immunol., 2006;176(4):2568-80.
      Species: Mouse
      Sample Type: Serum
    89. Experimental gastrointestinal allergy enhances pulmonary responses to specific and unrelated allergens.
      Authors: Brandt EB, Scribner TA, Akei HS, Rothenberg ME
      J. Allergy Clin. Immunol., 2006;118(2):420-7.
      Species: Mouse
      Sample Type: BALF
    90. Intranasal mite allergen induces allergic asthma-like responses in NC/Nga mice.
      Authors: Shibamori M, Ogino K, Kambayashi Y, Ishiyama H
      Life Sci., 2005;78(9):987-94.
      Species: Mouse
      Sample Type: BALF
    91. Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice.
      Authors: Duan W, Chan JH, McKay K, Crosby JR, Choo HH, Leung BP, Karras JG, Wong WS
      Am. J. Respir. Crit. Care Med., 2005;171(6):571-8.
      Species: Mouse
      Sample Type: BALF
    92. MyD88-dependent induction of allergic Th2 responses to intranasal antigen.
      Authors: Piggott DA, Eisenbarth SC, Xu L, Constant SL, Huleatt JW, Herrick CA, Bottomly K
      J. Clin. Invest., 2005;115(2):459-67.
      Species: Human
      Sample Type: Cell Culture Supernates
    93. Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice.
      Authors: Leino MS, Alenius HT, Fyhrquist-Vanni N, Wolff HJ, Reijula KE, Hintikka EL, Salkinoja-Salonen MS, Haahtela T, Mäkelä MJ
      Am. J. Respir. Crit. Care Med., 2005;173(5):512-8.
      Species: Mouse
      Sample Type: BALF
    94. Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma.
      Authors: Virag L, Bai P, Bak I, Pacher P, Mabley JG, Liaudet L, Bakondi E, Gergely P, Kollai M, Szabo C
      Med. Sci. Monit., 2004;10(3):BR77-83.
      Species: Mouse
      Sample Type: BALF
    95. Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV.
      Authors: Johnson TR, Varga SM, Braciale TJ, Graham BS
      J. Virol., 2004;78(16):8753-60.
      Species: Mouse
      Sample Type: Tissue Homogenates
    96. Persistence of bronchopulmonary hyper-reactivity and eosinophilic lung inflammation after anti-IL-5 or -IL-13 treatment in allergic BALB/c and IL-4Ralpha knockout mice.
      Authors: Proust B, Nahori MA, Ruffie C, Lefort J, Vargaftig BB
      Clin. Exp. Allergy, 2003;33(1):119-31.
      Species: Mouse
      Sample Type: BALF
    97. MHC class II-associated invariant chain isoforms regulate pulmonary immune responses.
      Authors: Ye Q, Finn PW, Sweeney R, Bikoff EK, Riese RJ
      J. Immunol., 2003;170(3):1473-80.
      Species: Mouse
      Sample Type: BALF
    98. Interleukin-9 induces mucous cell metaplasia independent of inflammation.
      Authors: Reader JR, Hyde DM, Schelegle ES, Aldrich MC, Stoddard AM, McLane MP, Levitt RC, Tepper JS
      Am. J. Respir. Cell Mol. Biol., 2003;28(6):664-72.
      Species: Mouse
      Sample Type: BALF
    99. Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice.
      Authors: Kobayashi T, Iijima K, Kita H
      J. Immunol., 2003;170(11):5756-63.
      Species: Mouse
      Sample Type: BALF
    100. Dual roles of IL-4 in lung injury and fibrosis.
      Authors: Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH
      J. Immunol., 2003;170(4):2083-92.
      Species: Mouse
      Sample Type: Serum
    101. IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen.
      Authors: Herrick CA, Xu L, McKenzie AN, Tigelaar RE, Bottomly K
      J. Immunol., 2003;170(5):2488-95.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    102. Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy.
      Authors: Drouin SM, Corry DB, Hollman TJ, Kildsgaard J, Wetsel RA
      J. Immunol., 2002;169(10):5926-33.
      Species: Mouse
      Sample Type: BALF
    103. IFN-gamma, but not Fas, mediates reduction of allergen-induced mucous cell metaplasia by inducing apoptosis.
      Authors: Shi ZO, Fischer MJ, De Sanctis GT, Schuyler MR, Tesfaigzi Y
      J. Immunol., 2002;168(9):4764-71.
      Species: Mouse
      Sample Type: BALF
    Expand to show all 103 Citations
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