Mouse IL-13 R alpha 2 Biotinylated Antibody
Mouse IL-13 R alpha 2 Biotinylated Antibody Summary
Accession # O88786
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-13 R alpha 2
Two type1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha, IL-13 R alpha ' or NR4, is now referred to as IL-13 R alpha 1. The high affinity IL-13 binding protein, previously also designated IL-13 R or IL-13 R alpha ', is now referred to as IL-13 R alpha 2.
The mouse IL-13 R alpha 2 cDNA encodes a 383 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 313 residue extracellular domain, a 22 aa residue transmembrane region and a 27 aa residue cytoplasmic tail. Human and mouse IL-13 R alpha 2 share 59% aa sequence identity. The extracellular domain of IL-13 R alpha 2 is also closely related to that of IL-13 R alpha 1. However, the cytoplasmic domain of IL-13 R alpha 2 lacks the box 1 and box 2 signaling motif and is much shorter than that of IL-13 R alpha 1, suggesting that the two receptors are functionally distinct. IL-13 R alpha 1 has been shown to combine with IL-4 R alpha to form a high-affinity receptor complex capable of transducing both an IL-4-dependent and an IL-13-dependent proliferative signal. The role of IL-13 R alpha 2 in IL-13 signaling remains to be elucidated. The amino-terminal 27 amino acid residues of mouse IL-13 R alpha 2 are identical to that of a soluble mouse IL-13 binding protein purified from mouse serum and urine.
- Donaldson, D.D. et al. (1998) J. Immunol. 161:2317.
- Chomarat, P. and J. Banchereau (1998) Int. Rev. Immunol. 17:1.
Citations for Mouse IL-13 R alpha 2 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 3
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M2-polarized macrophages contribute to neovasculogenesis, leading to relapse of oral cancer following radiation
Authors: Makiko Okubo
Sci Rep, 2016;6(0):27548.
Sample Types: Cell Lysates
Applications: Western Blot
Diesel exhaust particles induce cysteine oxidation and s-glutathionylation in house dust mite induced murine asthma.
Authors: Lee, Gerald B, Brandt, Eric B, Xiao, Chang, Gibson, Aaron M, Le Cras, Timothy, Brown, Lou Ann, Fitzpatrick, Anne M, Khurana Hershey, Gurjit K
PLoS ONE, 2013;8(3):e60632.
Sample Types: BALF
Applications: ELISA Development (Detection)
Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor alpha2 in vivo.
Authors: Chen W, Tabata Y, Gibson AM, Daines MO, Warrier MR, Wills-Karp M, Hershey GK
J. Allergy Clin. Immunol., 2008;122(3):625-32.
Sample Types: Cell Culture Supernates
Applications: ELISA Development
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