Mouse IL-17RA/IL-17R Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB448S Datasheet / COA / SDS

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FAB448S-100UG

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Mouse IL-17RA/IL-17R Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse IL‑17 RA/IL‑17 R in direct ELISAs and Western blots. Shows 50-100% cross‑reactivity with recombinant human IL-17 RA/IL-17 R and no cross‑reactivity with recombinant mouse IL-17B R.

Source

Monoclonal Rat IgG2b Clone # 105828

Purification

Protein A or G purified

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse ILâ€‘17 RA/ILâ€‘17 R
Extracellular domain
Accession # Q60943

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: IL-17RA/IL-17R

IL-17 R, also known as IL-17 RA, is a widely expressed 120 kDa glycosylated type I protein that plays a central role in inflammatory responses. IL-17 R associates with IL-17 RC to form a signaling receptor complex for IL-17 and IL-17F. IL-17 R ligation promotes T cell activation and the production of IL-6, G-CSF, SCF, and multiple proinflammatory chemokines. Within the ECD, human IL-17 R shares 72% aa sequence identity with mouse and rat IL-17 R.

Long Name

Interleukin 17 Receptor

Entrez Gene IDs

23765 (Human); 16172 (Mouse); 312679 (Rat); 486759 (Canine); 101925679 (Cynomolgus Monkey)

Alternate Names

CD217 antigen; CD217; Cdw217; CDw217interleukin 17 receptor; hIL-17R; IL-17 R; IL-17 RA; IL-17 receptor A; IL17RA; IL-17RA; IL-17RAMGC10262; IL17Rinterleukin-17 receptor A; interleukin 17 receptor A