Mouse IL-17RA/IL-17R Antibody

Catalog # Availability Size / Price Qty
MAB448
MAB448-SP
Detection of Mouse IL‑17 RA/IL‑17 R by Western Blot.
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Citations (1)
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Mouse IL-17RA/IL-17R Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse IL‑17 RA/IL‑17 R in direct ELISAs and Western blots. Shows 50-100% cross‑reactivity with recombinant human IL-17 RA/IL-17 R and no cross‑reactivity with recombinant mouse IL-17B R.
Source
Monoclonal Rat IgG2B Clone # 105828
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse IL‑17 RA/IL‑17 R
Extracellular domain
Accession # Q60943
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
2 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Mouse IL-17 RA/IL-17 R antibody by Western Blot. View Larger

Detection of Mouse IL‑17 RA/IL‑17 R by Western Blot. Western blot shows lysates of RAW 264.7 mouse monocyte/macrophage cell line. PVDF membrane was probed with 2 µg/mL of Rat Anti-Mouse IL-17 RA/IL-17 R Monoclonal Antibody (Catalog # MAB448) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005). A specific band was detected for IL-17 RA/IL-17 R at approximately 150 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-17RA/IL-17R

IL-17 R, also known as IL-17 RA, is a widely expressed 120 kDa glycosylated type I protein that plays a central role in inflammatory responses. IL-17 R associates with IL-17 RC to form a signaling receptor complex for IL-17 and IL-17F. IL-17 R ligation promotes T cell activation and the production of IL-6, G-CSF, SCF, and multiple proinflammatory chemokines. Within the ECD, human IL-17 R shares 72% aa sequence identity with mouse and rat IL-17 R.

Long Name
Interleukin 17 Receptor
Entrez Gene IDs
23765 (Human); 16172 (Mouse); 312679 (Rat); 486759 (Canine); 101925679 (Cynomolgus Monkey)
Alternate Names
CD217 antigen; CD217; Cdw217; CDw217interleukin 17 receptor; hIL-17R; IL-17 R; IL-17 RA; IL-17 receptor A; IL17RA; IL-17RA; IL-17RAMGC10262; IL17Rinterleukin-17 receptor A; interleukin 17 receptor A

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Citation for Mouse IL-17RA/IL-17R Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Production and functions of IL-17 in microglia.
    Authors: Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H, Suzumura A
    J. Neuroimmunol., 2007-12-31;194(1):54-61.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot

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