Detection of MS4A4B in NS0 Mouse Cell Line by Flow Cytometry. NS0 mouse myeloma cell line transfected with mouse MS4A4B and eGFP was stained with either (A) Rat Anti-Mouse MS4A4B APC‑conjugated Monoclonal Antibody (Catalog # FAB4504A) or (B) Rat IgG2A Allophycocyanin Isotype Control (Catalog # IC006A). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
Membrane Spanning 4 domain family, subfamily A4B (MS4A4B), also known as Chandra, is a member of the MS4A family of four-transmembrane proteins that includes CD20. It is expressed in immature CD4-CD8- T cells, NKT cells, CD4+ and CD8+ T cells, CD4+CD25+FoxP3+ Tregs and later in mature Th1 but not Th2 cells. MS4A4B is enriched in lipid rafts of activated T cells, and overexpression enhances Th1 cytokine expression, indicating a possible role in cell signaling.
Membrane-spanning 4-domains, Subfamily A, Member 4B
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