Mouse Neogenin Antibody
Mouse Neogenin Antibody Summary
Ala42-Ile1033 (Asp442-Leu461 del)
Accession # NP_032710
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Neogenin (NEO) is a type I transmembrane protein that is crucial for axonal guidance and neuronal migration. It is also involved in regulating differentiation programs in many embryonic and adult tissues (1). Mouse NEO is widely expressed in adult tissues and is expressed throughout the mid to late stages of gestation, in both neuronal and non-neuronal tissues. It is a member of the immunoglobulin (Ig) superfamily and is closely related to deleted in colorectal cancer (DCC). Mouse NEO cDNA encodes a 1493 amino acid residue (aa) precursor with a putative 36 aa signal peptide, a 1100 aa extracellular domain with six Ig-like C2 type domains and three fibronectin type III domains, a 21 aa transmembrane domain, and a 345 aa cytoplasmic domain. At least five isoforms are produced in mice by alternative splicing. Mouse NEO shares 96%, 93%, and 86% aa sequence identity with rat, human, and chicken NEO, respectively. It also has 46% and 29% sequence homology with mouse DCC and C. elegans UNC40, a homolog of DCC. NEO and DCC, together with the UNC5 family of type I transmembrane proteins, are receptors for the netrin/UNC6 family of laminin-related bifunctional guidance molecules that both attract some axons and repel others (2, 3). In mouse, at least five netrins (netrin‑1, ‑3, -4, G1, and G2) have been identified (3-5). Mouse netrin-1 and netrin-3 have been shown to be ligands for mouse NEO.
- Keeling, S.L. et al. (1997) Oncogene 15:691.
- Hong, K. et al. (1999) Cell 97:927.
- Livesey, F.J. (1999) Cell Mol. Life Sci. 56:62.
- Nakashiba, T. et al. (2000) J. Neurosci. 20:6540.
- Nakashiba, T. et al. (2002) Mech. Dev. 111:47.
Product Specific NoticesThis product or the use of this product is covered by U.S. Patents owned by The Regents of the University of California. This product is for research use only and is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic, therapeutic or drug discovery purposes is prohibited. In order to obtain a license to use this product for such purposes, contact The Regents of the University of California.
U.S. Patent # 5,939,271, 6,277,585, and other U.S. and international patents pending.
Citation for Mouse Neogenin Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
RGMa regulates cortical interneuron migration and differentiation.
Authors: O'Leary, Conor, Cole, Stacey J, Langford, Michael, Hewage, Jayani, White, Amanda, Cooper, Helen M
PLoS ONE, 2013-11-27;8(11):e81711.
Sample Types: Whole Cells
What is the light chain isotype of Mouse Neogenin Antibody, Catalog # MAB1079?
MAB1079 is kappa light chain.
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