Mouse Nogo Receptor/NgR Antibody

Catalog # Availability Size / Price Qty
MAB1659
MAB1659-SP
Product Details
Citations (1)
FAQs
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Mouse Nogo Receptor/NgR Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse NgR in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross-react with recombinant human NgR.
Source
Monoclonal Rat IgG2B Clone # 202604
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse NgR
Cys27-Ser447
Accession # Q99PI8
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Mouse Nogo Receptor/NgR Fc Chimera (Catalog # 1440-NG)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Nogo Receptor/NgR

NgR,also named reticulon 4 receptor, is a glycosylphosphoinositol (GPI)-anchored proteinthat belongs to the family of leucine-rich repeat proteins. NgR plays an essential role inmediating axon growth inhibition induced by the myelin-derived proteins Nogo, myelinassociatedglycoprotein (MAG), and myelin oligodendrocyte glycoprotein (Omgp). Uponligand binding, NgR associates with and activates the p75 neurotrophin receptor(p75NTR), a tumor necrosis factor superfamily member (TNFRSF16).

Long Name
Nogo-66 Receptor/Reticulon 4 Receptor
Entrez Gene IDs
65078 (Human); 65079 (Mouse)
Alternate Names
NgR; NgR1; Nogo R; Nogo receptor; Nogo-66 receptor; NogoR; NOGORUNQ330/PRO526; reticulon 4 receptor; reticulon-4 receptor; RTN4R

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Citation for Mouse Nogo Receptor/NgR Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Nogo receptor expression in microglia/macrophages during experimental autoimmune encephalomyelitis progression
    Authors: AA Alrehaili, JY Lee, MM Bakhuraysa, MJ Kim, PM Aui, KA Magee, S Petratos
    Neural Regen Res, 2018-05-01;13(5):896-907.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC

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