TGF-beta 3 (transforming growth factor beta 3) Is a pleiotropic cytokine that regulates immune function, proliferation, and epithelial-mesenchymal transition. Disulfide-linked homodimers of LAP and TGF-beta 3 remain non-covalently associated after secretion, forming the small latent TGF-beta 3 complex. Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix. Bioactive TGF-beta is released by proteolytic cleavage. TGF-beta 3 signals through a receptor complex containing TGF-beta RII and either TGF-beta RI/ALK5 or ALK1.
Mouse TGF-beta 3 (NP_033394.2) VersaClone cDNA
R&D Systems | Catalog # RDC3656
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Background: TGF-beta 3
Long Name
Transforming Growth Factor beta 3
Alternate Names
ARVD1, LDS5, RNHF, TGFB3, TGFbeta 3
Gene Symbol
TGFB3
UniProt
Additional TGF-beta 3 Products
Product Documents for Mouse TGF-beta 3 (NP_033394.2) VersaClone cDNA
Certificate of Analysis
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Product Specific Notices for Mouse TGF-beta 3 (NP_033394.2) VersaClone cDNA
For research use only
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Associated Pathways
