MPP dihydrochloride

Tocris Bioscience | Catalog # 1991

Highly selective ERα antagonist
Tocris Bioscience

Key Product Details

Description

Highly selective ERα antagonist
View all Estrogen and Related Receptor Antagonists »

Product Description

MPP dihydrochloride is a selective, high affinity silent antagonist at ERα receptors. Displays > 200-fold selectivity for ERα over ERβ. Ki values are 2.7 and 1800 nM at ERα and ERβ receptors respectively.

Product Specifications for MPP dihydrochloride

Molecular Weight

542.50

Formula

C29H31N3O3.2HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride

CAS Number

911295-24-4

PubChem ID

45073474

InChI Key

SMPRQALBFACGGO-UHFFFAOYSA-N

SMILES

OC(C=C4)=CC=C4N1C(C(C=C3)=CC=C3OCCN2CCCCC2)=C(C)C(C5=CC=C(O)C=C5)=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.25 100

Preparing Stock Solutions for MPP dihydrochloride

The following data is based on the product molecular weight 542.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.84 mL 9.22 mL 18.43 mL
5 mM 0.37 mL 1.84 mL 3.69 mL
10 mM 0.18 mL 0.92 mL 1.84 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 148 publications citing the usage of this product.

Product Documents for MPP dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MPP dihydrochloride

For research use only

Citations for MPP dihydrochloride

Customer Reviews for MPP dihydrochloride (1)

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  • Effective estrogen receptor a inhibition
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Macrophages
    Verified Customer | Posted 09/12/2024
    Add the inhibitor at the first day.
    To inhibit the estrogen receptor a signaling functions in M1-TAM cocultured with endothelial cells.
    MPP dihydrochloride 1991

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