MuRF1/TRIM63 Auto-Ubiquitination Kit
MuRF1/TRIM63 Auto-Ubiquitination Kit Summary
Specifications
Product Datasheets
Background: MuRF1/TRIM63
TRIM63 (Tripartite motif-containing protein 63; also MURF-1, SMRZ and RING finger protein 28) is a 41 kDa member of the RING finger-B-box-coiled-coil family of proteins. It is a striated muscle protein that is found in both cytoplasm and nucleus. TRIM63 has multiple finctions, among which are the inhibition of PKC epsilon-mediated cardiomyocyte hypertrophy and the maintenance of skeletal muscle M-line integrity. Human TRIM63 is 353 amino acids (aa) in length. It contains one RING finger domain (aa 23-82), a B-Box type zinc-finger region (aa 117-159), a coiled-coil region (aa 207-269) and a C-terminal COS domain. Isoforms of TRIM63 show one potential alternate start site at Met14, a deletion of aa 105-132 and a 21 aa substitution for aa 326-353. Over aa 1-325, human TRIM63 exhibits 93% aa identity with mouse TRIM63.
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Citations for MuRF1/TRIM63 Auto-Ubiquitination Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading
Authors: Y Xu, S Du, JA Marsh, K Horie, C Sato, A Ballabio, CM Karch, DM Holtzman, H Zheng
Mol. Psychiatry, 2020-05-04;0(0):. 2020-05-04
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Regulation of Eosinophil Recruitment and Allergic Airway Inflammation by Tropomyosin Receptor Kinase A
Authors: M Dileepan, XN Ge, I Bastan, YG Greenberg, Y Liang, P Sriramarao, SP Rao
J. Immunol., 2019-12-23;0(0):. 2019-12-23
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LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer
Authors: KJ Carpenter, AC Valfort, N Steinauer, A Chatterjee, S Abuirqeba, S Majidi, M Sengupta, RJ Di Paolo, LP Shornick, J Zhang, CA Flaveny
Sci Rep, 2019-12-20;9(1):19530. 2019-12-20
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Reducing Th2 inflammation through neutralizing IL-4 antibody rescues myelination in IUGR rat brain
Authors: AE Zanno, MA Romer, L Fox, T Golden, L Jaeckle-Sa, RA Simmons, JB Grinspan
J Neurodev Disord, 2019-12-16;11(1):34. 2019-12-16
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Characterization of the local wound environment following treatment of chronic leg ulcers with SIS wound matrix
Authors: JP Hodde, MC Hiles, DW Metzger
J Tissue Viability, 2019-12-13;0(0):. 2019-12-13
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E-cigarette flavored pods induce inflammation, epithelial barrier dysfunction, and DNA damage in lung epithelial cells and monocytes
Authors: T Muthumalag, T Lamb, MR Friedman, I Rahman
Sci Rep, 2019-12-13;9(1):19035. 2019-12-13
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Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype
Authors: F Roudnicky, Y Lan, M Friesen, G Dernick, JD Zhang, A Staempfli, N Bordag, A Wagner-Gol, K Christense, M Ebeling, M Graf, M Burcin, CA Meyer, CA Cowan, C Patsch
Int J Mol Sci, 2019-12-09;20(24):. 2019-12-09
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Respiratory syncytial virus exhibits differential tropism for distinct human placental cell types with Hofbauer cells acting as a permissive reservoir for infection
Authors: V Bokun, JJ Moore, R Moore, CC Smallcombe, TJ Harford, F Rezaee, F Esper, G Piedimonte
PLoS ONE, 2019-12-02;14(12):e0225767. 2019-12-02
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Patients with Idiopathic Pulmonary Nontuberculous Mycobacterial Disease Have Normal Th1/Th2 Cytokine Responses but Diminished Th17 Cytokine and Enhanced Granulocyte-Macrophage Colony-Stimulating Factor Production
Authors: UI Wu, KN Olivier, DB Kuhns, DL Fink, EP Sampaio, AM Zelazny, SJ Shallom, BE Marciano, MS Lionakis, SM Holland
Open Forum Infect Dis, 2019-11-28;6(12):ofz484. 2019-11-28
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Doublecortin like kinase 1 regulates alpha-Synuclein levels and toxicity
Authors: GE Vázquez-Vé, KA Gonzales, JP Revelli, CJ Adamski, F Alavi Nain, A Baji?, E Craigen, R Richman, SM Heman-Acka, MJA Wood, MWC Rousseaux, HY Zoghbi
J. Neurosci., 2019-11-20;0(0):. 2019-11-20
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mTOR and autophagy pathways are dysregulated in murine and human models of Schaaf-Yang syndrome
Authors: E Crutcher, R Pal, F Naini, P Zhang, M Laugsch, J Kim, A Bajic, CP Schaaf
Sci Rep, 2019-11-04;9(1):15935. 2019-11-04
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Let-7 regulates cell cycle dynamics in the developing cerebral cortex and retina
Authors: CLA Fairchild, SK Cheema, J Wong, K Hino, S Simó, A La Torre
Sci Rep, 2019-10-25;9(1):15336. 2019-10-25
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CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus
Authors: Y Koutmani, IA Gampieraki, A Polissidis, M Ximerakis, PN Koutsoudak, A Polyzos, G Agrogianni, S Karaliota, D Thomaidou, LL Rubin, PK Politis, KP Karalis
Cell Rep, 2019-10-22;29(4):932-945.e7. 2019-10-22
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Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection
Authors: KD Hebert, N Mclaughlin, M Galeas-Pen, Z Zhang, T Eddens, A Govero, JM Pilewski, JK Kolls, DA Pociask
Mucosal Immunol, 2019-10-09;0(0):. 2019-10-09
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A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice
Authors: S Varshney, HX Wei, F Batista, M Nauman, S Sundaram, K Siminovitc, A Tanwar, P Stanley
BMC Dev. Biol., 2019-10-07;19(1):19. 2019-10-07
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Siglec-8 antibody reduces eosinophil and mast cell infiltration in a transgenic mouse model of eosinophilic gastroenteritis
Authors: BA Youngblood, EC Brock, J Leung, R Falahati, BS Bochner, HS Rasmussen, K Peterson, C Bebbington, N Tomasevic
JCI Insight, 2019-10-03;0(0):. 2019-10-03
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Increased Maternal Prenatal Adiposity, Inflammation, and Lower Omega-3 Fatty Acid Levels Influence Child Negative Affect
Authors: HC Gustafsson, KF Holton, AN Anderson, EK Nousen, CA Sullivan, JM Loftis, JT Nigg, EL Sullivan
Front Neurosci, 2019-10-01;13(0):1035. 2019-10-01
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PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism
Authors: RR Stine, AP Sakers, T TeSlaa, M Kissig, ZE Stine, CW Kwon, L Cheng, HW Lim, KH Kaestner, JD Rabinowitz, P Seale
Cell Stem Cell, 2019-09-26;0(0):. 2019-09-26
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Control over single-cell distribution of G1 lengths by WNT governs pluripotency
Authors: J Jang, D Han, M Golkaram, M Audouard, G Liu, D Bridges, S Hellander, A Chialastri, SS Dey, LR Petzold, KS Kosik
PLoS Biol., 2019-09-26;17(9):e3000453. 2019-09-26
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Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
Authors: V Lungova, X Chen, Z Wang, C Kendziorsk, SL Thibeault
Nat Commun, 2019-09-24;10(1):4161. 2019-09-24
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Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons
Authors: M Riessland, B Kolisnyk, TW Kim, J Cheng, J Ni, JA Pearson, EJ Park, K Dam, D Acehan, LS Ramos-Espi, W Wang, J Zhang, JW Shim, G Ciceri, L Brichta, L Studer, P Greengard
Cell Stem Cell, 2019-09-19;25(4):514-530.e8. 2019-09-19
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PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity
Authors: MW LaFleur, TH Nguyen, MA Coxe, BC Miller, KB Yates, JE Gillis, DR Sen, EF Gaudiano, R Al Abosy, GJ Freeman, WN Haining, AH Sharpe
Nat. Immunol., 2019-09-16;20(10):1335-1347. 2019-09-16
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Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models
Authors: JC Chamcheu, S Esnault, VM Adhami, AL Noll, S Banang-Mbe, T Roy, SS Singh, S Huang, KG Kousoulas, H Mukhtar
Cells, 2019-09-15;8(9):. 2019-09-15
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Focal Adhesion Kinase Inhibition Contributes to Tumor Cell Survival and Motility in Neuroblastoma Patient-Derived Xenografts
Authors: LL Stafman, AP Williams, R Marayati, JM Aye, HR Markert, EF Garner, CH Quinn, SB Lallani, JE Stewart, KJ Yoon, K Whelan, EA Beierle
Sci Rep, 2019-09-13;9(1):13259. 2019-09-13
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Controlled modelling of human epiblast and amnion development using stem cells
Authors: Y Zheng, X Xue, Y Shao, S Wang, SN Esfahani, Z Li, JM Muncie, JN Lakins, VM Weaver, DL Gumucio, J Fu
Nature, 2019-09-11;573(7774):421-425. 2019-09-11
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Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth
Authors: N Gomez-Lope, R Romero, Y Xu, D Miller, M Arenas-Her, V Garcia-Flo, B Panaitescu, J Galaz, CD Hsu, R Para, SM Berry
J. Immunol., 2019-09-06;0(0):. 2019-09-06
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Androgens augment pulmonary responses to ozone in mice
Authors: RS Osgood, DI Kasahara, H Tashiro, Y Cho, SA Shore
Physiol Rep, 2019-09-01;7(18):e14214. 2019-09-01
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Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBP? in Alzheimer's Disease
Authors: ZH Wang, J Xiang, X Liu, SP Yu, FP Manfredsso, IM Sandoval, S Wu, JZ Wang, K Ye
Cell Rep, 2019-07-16;28(3):655-669.e5. 2019-07-16
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Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch
Authors: D Acton, X Ren, S Di Costanz, A Dalet, S Bourane, I Bertocchi, C Eva, M Goulding
Cell Rep, 2019-07-16;28(3):625-639.e6. 2019-07-16
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Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo
Authors: S Moghadasi, A Koontz, G Tseropoulo, L Kerosuo, P Mehrotra, VK Bajpai, SR Selvam, P Lei, ME Bronner, ST Andreadis
Sci Rep, 2019-07-05;9(1):9750. 2019-07-05
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Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells
Authors: AI Segaliny, JL Cheng, HP Farhoodi, M Toledano, CC Yu, B Tierra, L Hildebrand, L Liu, MJ Liao, J Cho, D Liu, L Sun, G Gulsen, MY Su, RL Sah, W Zhao
EBioMedicine, 2019-07-04;45(0):39-57. 2019-07-04
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Bacterial Translocation and Host Immune Activation in Chronic Hepatitis C Infection
Authors: MS Moon, G Quinn, EC Townsend, RO Ali, GY Zhang, A Bradshaw, K Hill, H Guan, D Hamilton, DE Kleiner, C Koh, T Heller
Open Forum Infect Dis, 2019-07-01;6(7):. 2019-07-01
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Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL
Authors: M Epeldegui, DV Conti, Y Guo, W Cozen, ML Penichet, O Martínez-M
Sci Rep, 2019-06-28;9(1):9371. 2019-06-28
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Biomarkers of cavernous angioma with symptomatic hemorrhage
Authors: SB Lyne, R Girard, J Koskimäki, HA Zeineddine, D Zhang, Y Cao, Y Li, A Stadnik, T Moore, R Lightle, C Shi, R Shenkar, J Carrión-Pe, SP Polster, S Romanos, A Akers, M Lopez-Rami, KJ Whitehead, ML Kahn, MH Ginsberg, DA Marchuk, IA Awad
JCI Insight, 2019-06-20;4(12):. 2019-06-20
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High-density lipoprotein cholesterol is associated with multiple sclerosis fatigue: A�fatigue-metabolism nexus?
Authors: RW Browne, D Jakimovski, N Ziliotto, J Kuhle, F Bernardi, B Weinstock-, R Zivadinov, M Ramanathan
J Clin Lipidol, 2019-06-18;0(0):. 2019-06-18
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Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells
Authors: M Rosenbaum, A Gewies, K Pechloff, C Heuser, T Engleitner, T Gehring, L Hartjes, S Krebs, D Krappmann, M Kriegsmann, W Weichert, R Rad, C Kurts, J Ruland
Nat Commun, 2019-05-28;10(1):2352. 2019-05-28
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Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis
Authors: G Genet, K Boyé, T Mathivet, R Ola, F Zhang, A Dubrac, J Li, N Genet, L Henrique G, L Benedetti, S Künzel, L Pibouin-Fr, JL Thomas, A Eichmann
Nat Commun, 2019-05-28;10(1):2350. 2019-05-28
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Molecular Logic of Spinocerebellar Tract Neuron Diversity and Connectivity
Authors: M Baek, V Menon, TM Jessell, AW Hantman, JS Dasen
Cell Rep, 2019-05-28;27(9):2620-2635.e4. 2019-05-28
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Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis
Authors: BD Bryson, TR Rosebrock, FG Tafesse, CY Itoh, A Nibasumba, GH Babunovic, B Corleis, C Martin, C Keegan, P Andrade, S Realegeno, D Kwon, RL Modlin, SM Fortune
Nat Commun, 2019-05-27;10(1):2329. 2019-05-27
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Nicotinamide phosphoribosyltransferase is a molecular target of potent anticancer agents identified from phenotype-based drug screening
Authors: D Yamaguchi, T Imaizumi, K Yagi, Y Matsumoto, T Nakashima, A Hirose, N Kashima, Y Nosaka, T Hamada, K Okawa, Y Nishiya, K Kubo
Sci Rep, 2019-05-23;9(1):7742. 2019-05-23
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Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis
Authors: DK Kaushik, A Bhattachar, R Mirzaei, KS Rawji, Y Ahn, JM Rho, VW Yong
J. Clin. Invest., 2019-05-21;130(0):. 2019-05-21
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Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression
Authors: S Lotinun, Y Ishihara, K Nagano, R Kiviranta, V Carpentier, L Neff, V Parkman, N Ide, D Hu, P Dann, D Brooks, ML Bouxsein, J Wysolmersk, F Gori, R Baron
J. Clin. Invest., 2019-05-21;130(0):. 2019-05-21
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The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression
Authors: ME Grunewald, Y Chen, C Kuny, T Maejima, R Lease, D Ferraris, M Aikawa, CS Sullivan, S Perlman, AR Fehr
PLoS Pathog., 2019-05-16;15(5):e1007756. 2019-05-16
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Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle
Authors: MN Wosczyna, CT Konishi, EE Perez Carb, TT Wang, RA Walsh, Q Gan, MW Wagner, TA Rando
Cell Rep, 2019-05-14;27(7):2029-2035.e5. 2019-05-14
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Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines
Authors: CS Umeshappa, S Singha, J Blanco, K Shao, RH Nanjundapp, J Yamanouchi, A Parés, P Serra, Y Yang, P Santamaria
Nat Commun, 2019-05-14;10(1):2150. 2019-05-14
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Salmonella Translocated Effectors Recruit OSBP1 to the Phagosome to Promote Vacuolar Membrane Integrity
Authors: AM Kolodzieje, MA Altura, J Fan, EM Petersen, M Cook, PS Brzovic, SI Miller
Cell Rep, 2019-05-14;27(7):2147-2156.e5. 2019-05-14
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Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB
Authors: F Mahjour, V Dambal, N Shrestha, V Singh, V Noonan, A Kantarci, PC Trackman
Oncogenesis, 2019-05-13;8(5):34. 2019-05-13
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Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease
Authors: SW Wong, BW Huang, X Hu, E Ho Kim, JP Kolb, RJ Padilla, P Xue, L Wang, TH Oguin, PA Miguez, HC Tseng, CC Ko, J Martinez
Cell Death Differ., 2019-05-10;0(0):. 2019-05-10
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G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche
Authors: Z Li, J Hardij, SS Evers, CR Hutch, SM Choi, Y Shao, BS Learman, KT Lewis, RL Schill, H Mori, DP Bagchi, SM Romanelli, KS Kim, E Bowers, C Griffin, RJ Seeley, K Singer, DA Sandoval, CJ Rosen, OA MacDougald
J. Clin. Invest., 2019-05-06;129(6):2404-2416. 2019-05-06
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Respiratory frequency plasticity during development
Authors: SM Johnson, KS Randhawa, TL Baker, JJ Watters
Respir Physiol Neurobiol, 2019-05-03;0(0):. 2019-05-03
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Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2
Authors: E Slocum, A Craig, A Villanueva, D Germain
Breast Cancer Res., 2019-05-02;21(1):56. 2019-05-02
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Pan-cancer genomic analysis links 3'UTR DNA methylation with increased gene expression in T cells
Authors: MH McGuire, SM Herbrich, SK Dasari, SY Wu, Y Wang, R Rupaimoole, G Lopez-Bere, KA Baggerly, AK Sood
EBioMedicine, 2019-05-02;0(0):. 2019-05-02
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Evaluation of Tumor Cell-Tumor Microenvironment Component Interactions as Potential Predictors of Patient Response to Napabucasin
Authors: AY Chang, E Hsu, J Patel, Y Li, M Zhang, H Iguchi, HA Rogoff
Mol. Cancer Res., 2019-05-01;0(0):. 2019-05-01
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Intrinsic Resistance to MEK Inhibition Through BET Protein Mediated Kinome Reprogramming in NF1-deficient Ovarian Cancer
Authors: AM Kurimchak, C Shelton, C Herrera-Mo, KE Duncan, J Chernoff, JS Duncan
Mol. Cancer Res., 2019-05-01;0(0):. 2019-05-01
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Dendritic cell NLRC4 regulates influenza A virus-specific CD4 T cell responses through FasL expression
Authors: EE Hornick, J Dagvadorj, ZR Zacharias, AM Miller, RA Langlois, P Chen, KL Legge, GA Bishop, FS Sutterwala, SL Cassel
J. Clin. Invest., 2019-04-30;130(0):. 2019-04-30
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Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model
Authors: E Krock, M Millecamps, KM Anderson, A Srivastava, TE Reihsen, P Hari, YR Sun, SH Jang, GL Wilcox, KG Belani, DS Beebe, J Ouellet, MR Pinto, LJ Kehl, L Haglund, LS Stone
EBioMedicine, 2019-04-30;0(0):. 2019-04-30
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Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival
Authors: P Kellish, D Shabashvil, MM Rahman, A Nawab, MV Guijarro, M Zhang, C Cao, N Moussatche, T Boyle, S Antonia, M Reinhard, C Hartzell, M Jantz, HJ Mehta, G McFadden, FJ Kaye, M Zajac-Kaye
J. Clin. Invest., 2019-04-29;130(0):. 2019-04-29
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Downregulation of CD73 associates with T cell exhaustion in AML patients
Authors: Y Kong, B Jia, C Zhao, DF Claxton, A Sharma, C Annageldiy, JS Fotos, H Zeng, RF Paulson, KS Prabhu, H Zheng
J Hematol Oncol, 2019-04-24;12(1):40. 2019-04-24
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Development of a Cx46 Targeting Strategy for Cancer Stem Cells
Authors: EE Mulkearns-, LA Torre-Heal, DJ Silver, JT Eurich, D Bayik, E Serbinowsk, M Hitomi, J Zhou, B Przychodze, R Zhang, SA Sprowls, JS Hale, TJ Alban, A Berezovsky, BA Bell, PR Lockman, BK Jha, JD Lathia
Cell Rep, 2019-04-23;27(4):1062-1072.e5. 2019-04-23
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Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells
Authors: JA Bernatchez, M Coste, S Beck, GA Wells, LA Luna, AE Clark, Z Zhu, D Hecht, JN Rich, CD Sohl, BW Purse, JL Siqueira-N
Viruses, 2019-04-20;11(4):. 2019-04-20
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Autophagy links antimicrobial activity with antigen presentation in Langerhans cells
Authors: AT Dang, RM Teles, PT Liu, A Choi, A Legaspi, EN Sarno, MT Ochoa, K Parvatiyar, G Cheng, M Gilliet, BR Bloom, RL Modlin
JCI Insight, 2019-04-18;4(8):. 2019-04-18
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Organoid culture media formulated with growth factors of defined cellular activity
Authors: M Urbischek, H Rannikmae, T Foets, K Ravn, M Hyvönen, M de la Roch
Sci Rep, 2019-04-17;9(1):6193. 2019-04-17
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ITGA2 as a potential nanotherapeutic target for glioblastoma
Authors: P Guo, A Moses-Gard, J Huang, ER Smith, MA Moses
Sci Rep, 2019-04-17;9(1):6195. 2019-04-17
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lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation
Authors: MJ Delás, BT Jackson, T Kovacevic, S Vangelisti, E Munera Mar, SA Wild, EM Stork, N Erard, SRV Knott, GJ Hannon
Cell Rep, 2019-04-16;27(3):719-729.e6. 2019-04-16
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PDGFR?+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland
Authors: PA Joshi, PD Waterhouse, K Kasaian, H Fang, O Gulyaeva, HS Sul, PC Boutros, R Khokha
Nat Commun, 2019-04-15;10(1):1760. 2019-04-15
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Assembly of Human Stem Cell-Derived Cortical Spheroids and Vascular Spheroids to Model 3-D Brain-like Tissues
Authors: L Song, X Yuan, Z Jones, K Griffin, Y Zhou, T Ma, Y Li
Sci Rep, 2019-04-12;9(1):5977. 2019-04-12
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MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis
Authors: NE Putnam, LE Fulbright, JM Curry, CA Ford, JR Petronglo, AS Hendrix, JE Cassat
PLoS Pathog., 2019-04-12;15(4):e1007744. 2019-04-12
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High social strain and physical health: Examining the roles of anxious arousal, body mass index, and inflammation
Authors: JE Guevara, KW Murdock
Psychoneuroendocrinology, 2019-04-05;106(0):155-160. 2019-04-05
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Chymase uptake by cardiomyocytes results in myosin degradation in cardiac volume overload
Authors: PC Powell, CC Wei, L Fu, B Pat, WE Bradley, JF Collawn, LJ Dell'Itali
Heliyon, 2019-04-04;5(4):e01397. 2019-04-04
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CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
Authors: JV Pluvinage, MS Haney, BAH Smith, J Sun, T Iram, L Bonanno, L Li, DP Lee, DW Morgens, AC Yang, SR Shuken, D Gate, M Scott, P Khatri, J Luo, CR Bertozzi, MC Bassik, T Wyss-Coray
Nature, 2019-04-03;0(0):. 2019-04-03
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Apicidin Attenuates MRSA Virulence through Quorum-Sensing Inhibition and Enhanced Host Defense
Authors: CP Parlet, JS Kavanaugh, HA Crosby, HA Raja, T El-Elimat, DA Todd, CJ Pearce, NB Cech, NH Oberlies, AR Horswill
Cell Rep, 2019-04-02;27(1):187-198.e6. 2019-04-02
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Resistance to visceral obesity is associated with increased locomotion in mice expressing an endothelial cell-specific fibroblast growth factor 1 transgene
Authors: T Keeley, A Kirov, WY Koh, V Demambro, I Bergquist, J Cotter, P Caradonna, ME Siviski, B Best, T Henderson, CJ Rosen, L Liaw, I Prudovsky, DJ Small
Physiol Rep, 2019-04-01;7(7):e14034. 2019-04-01
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Chronic infusion of interleukin-17 promotes hypertension, activation of cytolytic natural killer cells, and vascular dysfunction in pregnant rats
Authors: OK Travis, D White, WA Pierce, Y Ge, CY Stubbs, FT Spradley, JM Williams, DC Cornelius
Physiol Rep, 2019-04-01;7(7):e14038. 2019-04-01
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IL-1 and TNF? Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration
Authors: H Katsura, Y Kobayashi, PR Tata, BLM Hogan
Stem Cell Reports, 2019-03-28;0(0):. 2019-03-28
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Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis
Authors: AM Nicaise, LJ Wagstaff, CM Willis, C Paisie, H Chandok, P Robson, V Fossati, A Williams, SJ Crocker
Proc. Natl. Acad. Sci. U.S.A., 2019-03-25;0(0):. 2019-03-25
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IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection
Authors: P Kumar, K Rajasekara, A Nanbakhsh, J Gorski, MS Thakar, S Malarkanna
Sci Rep, 2019-03-21;9(1):4984. 2019-03-21
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Host and Bacterial Markers that Differ in Children with Cystitis and Pyelonephritis
Authors: N Shaikh, JM Martin, A Hoberman, M Skae, L Milkovich, A Nowalk, C McElheny, RW Hickey, D Kearney, M Majd, E Shalaby-Ra, G Tseng, JF Alcorn, J Kolls, M Kurs-Lasky, Z Huo, W Horne, G Lockhart, H Pohl, TR Shope
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MUC1-C INTEGRATES CHROMATIN REMODELING AND PARP1 ACTIVITY IN THE DNA DAMAGE RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER CELLS
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Frontline Science: Induction of experimental autoimmune encephalomyelitis mobilizes Th17-promoting myeloid derived suppressor cells to the lung
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A recombinant human IgG1 Fc multimer designed to mimic the active fraction of IVIG in autoimmunity
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Therapeutic efficacy of a novel ?III/?IV-tubulin inhibitor (VERU-111) in pancreatic cancer
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MYMD-1, a Novel Immunometabolic Regulator, Ameliorates Autoimmune Thyroiditis via Suppression of Th1 Responses and TNF-? Release
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Mucosal Immunol, 2019-01-21;0(0):. 2019-01-21
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Mucosal Immunol, 2019-01-07;12(2):545-554. 2019-01-07
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Functional Assessment of Patient-Derived Retinal Pigment Epithelial Cells Edited by CRISPR/Cas9
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Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms
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Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation
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Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues
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J. Clin. Invest., 2018-11-19;0(0):. 2018-11-19
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Vitamin D pathway activation selectively deactivates signal transducer and activator of transcription (STAT) proteins and inflammatory cytokine production in natural killer leukemic large granular lymphocytes
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Cytokine, 2018-11-17;111(0):551-562. 2018-11-17
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Phosphorylation and inhibition of ceramide kinase by protein kinase C-?: Their changes by serine residue mutations
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Cell. Signal., 2018-11-15;0(0):. 2018-11-15
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Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion
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Sci Adv, 2018-11-14;4(11):eaau9859. 2018-11-14
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Co-Expression of VEGF and IL-6 Family Cytokines is Associated with Decreased Survival in HER2 Negative Breast Cancer Patients: Subtype-Specific IL-6 Family Cytokine-Mediated VEGF Secretion
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Transl Oncol, 2018-11-12;12(2):245-255. 2018-11-12
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Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells
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Int J Mol Sci, 2018-11-09;19(11):. 2018-11-09
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?-3 fatty acids-supplementary in gestation alleviates neuroinflammation and modulates neurochemistry in rats
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Lipids Health Dis, 2018-11-03;17(1):247. 2018-11-03
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Non-obstructive vas deferens and epididymis loss in cystic fibrosis rats
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Mech. Dev., 2018-11-02;155(0):15-26. 2018-11-02
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Direct therapeutic targeting of immune checkpoint PD-1 in pancreatic cancer
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Br. J. Cancer, 2018-10-31;120(1):88-96. 2018-10-31
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Cyp1b1 expression impacts the angiogenic and inflammatory properties of liver sinusoidal endothelial cells
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PLoS ONE, 2018-10-29;13(10):e0206756. 2018-10-29
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Cell chirality regulates intercellular junctions and endothelial permeability
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Sci Adv, 2018-10-24;4(10):eaat2111. 2018-10-24
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Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced S�zary syndrome
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Leukemia, 2018-10-24;0(0):. 2018-10-24
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A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma
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Sci Rep, 2018-10-23;8(1):15664. 2018-10-23
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Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes
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Cell Rep, 2018-10-23;25(4):947-958.e4. 2018-10-23
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Curcumin, but not curcumin-glucuronide, inhibits Smad signaling in TGF?-dependent bone metastatic breast cancer cells and is enriched in bone compared to other tissues
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J. Nutr. Biochem., 2018-10-11;63(0):150-156. 2018-10-11
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Cutting Edge: IL-1? and Not IL-1? Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality
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J. Immunol., 2018-10-10;0(0):. 2018-10-10
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Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype
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Cell Rep, 2018-10-09;25(2):368-382.e5. 2018-10-09
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Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma
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Cell Death Differ., 2018-10-03;26(2):382-393. 2018-10-03
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Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection
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Nat Commun, 2018-10-01;9(1):3999. 2018-10-01
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Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus
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Nat Commun, 2018-09-28;9(1):3973. 2018-09-28
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Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells
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Cell Stem Cell, 2018-09-20;0(0):. 2018-09-20
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Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
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Nat Commun, 2018-09-19;9(1):3815. 2018-09-19
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All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo
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Genome Biol., 2018-09-19;19(1):137. 2018-09-19
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Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation
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Cell Mol Gastroenterol Hepatol, 2018-09-14;7(1):55-71. 2018-09-14
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Increased macrophages and�changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation
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Mol. Psychiatry, 2018-09-13;0(0):. 2018-09-13
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NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
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Nat Commun, 2018-08-27;9(1):3463. 2018-08-27
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Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury
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Mol Med Rep, 2018-08-24;0(0):. 2018-08-24
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Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming
Authors: AD Senft, I Costello, HW King, AW Mould, EK Bikoff, EJ Robertson
Cell Rep, 2018-08-21;24(8):1977-1985.e7. 2018-08-21
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Blocking the FSTL1-DIP2A Axis Improves Anti-tumor Immunity
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Cell Rep, 2018-08-14;24(7):1790-1801. 2018-08-14
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Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration
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Cell Stem Cell, 2018-08-09;0(0):. 2018-08-09
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Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions
Authors: SK Varanasi, NK Rajasagi, U Jaggi, BT Rouse
Mucosal Immunol, 2018-08-07;0(0):. 2018-08-07
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Marital distress, depression, and a leaky gut: Translocation of bacterial endotoxin as a pathway to inflammation
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Psychoneuroendocrinology, 2018-08-04;98(0):52-60. 2018-08-04
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The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity
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Nat Commun, 2018-08-03;9(1):3049. 2018-08-03
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Pre-clinical validation of B cell maturation antigen (BCMA) as a target for T cell immunotherapy of multiple myeloma
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Oncotarget, 2018-05-25;9(40):25764-25780. 2018-05-25
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Gene expression profiling of primary human type I alveolar epithelial cells exposed to Bacillus anthracis spores reveals induction of neutrophil and monocyte chemokines
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Microb. Pathog., 2018-04-25;0(0):. 2018-04-25
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IL-13 is produced by tumor cells in Breast Implant Associated Anaplastic Large Cell Lymphoma: Implications for pathogenesis
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Hum. Pathol., 2018-04-22;0(0):. 2018-04-22
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Adenovirus infection of human enteroids reveals interferon sensitivity and preferential infection of goblet cells
Authors: MK Holly, JG Smith
J. Virol., 2018-04-13;0(0):. 2018-04-13
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In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images
Authors: EM Christians, SJ Yang, DM Ando, A Javaherian, G Skibinski, S Lipnick, E Mount, A O'Neil, K Shah, AK Lee, P Goyal, W Fedus, R Poplin, A Esteva, M Berndl, LL Rubin, P Nelson, S Finkbeiner
Cell, 2018-04-12;173(3):792-803.e19. 2018-04-12
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Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses
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Orphanet J Rare Dis, 2018-04-10;13(1):54. 2018-04-10
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Pirfenidone inhibits cryoablation induced local macrophage infiltration along with its associated TGFb1 expression and serum cytokine level in a mouse model
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Cryobiology, 2018-04-03;0(0):. 2018-04-03
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The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis
Authors: JE Hoefert, GA Bjerke, D Wang, R Yi
J. Cell Biol., 2018-03-30;0(0):. 2018-03-30
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IL-21 regulates NK cell responses during Mycobacterium tuberculosis infection
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J. Infect. Dis., 2018-03-28;0(0):. 2018-03-28
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Specificity protein 7 is required for proliferation and differentiation of ameloblasts and odontoblasts
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J. Bone Miner. Res., 2018-03-24;0(0):. 2018-03-24
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iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications
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Cell, 2018-03-22;0(0):. 2018-03-22
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An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality
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Genes Dev., 2018-03-19;32(5):373-388. 2018-03-19
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The plasma interleukin-6 response to acute psychosocial stress in humans is detected by a magnetic multiplex assay: comparison to high-sensitivity ELISA
Authors: AM Quinn, AR Williams, TI Sivilli, CL Raison, TWW Pace
Stress, 2018-03-13;0(0):1-6. 2018-03-13
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Beta-Catenin maintains lung epithelial progenitors after lung specification
Authors: EJ Ostrin, DR Little, KN Gerner-Mau, EA Sumner, R Ríos-Corzo, E Ambrosio, SE Holt, NR Forcioli-C, H Akiyama, SM Hanash, S Kimura, SXL Huang, J Chen
Development, 2018-03-09;0(0):. 2018-03-09
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Face morphogenesis is promoted by Pbx-dependent EMT via regulation ofduring frontonasal prominence fusion
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Development, 2018-03-01;0(0):. 2018-03-01
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IL-27 Expression and Responsiveness in Human Uterine Epithelial Cells and Fibroblasts In Vitro and the Role of Estradiol
Authors: MV Patel, Z Shen, RM Rossoll, CR Wira
J. Interferon Cytokine Res., 2018-03-01;38(3):101-110. 2018-03-01
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BTKCys481Serdrives ibrutinib resistance via ERK1/2, and protects BTKWild-TypeMYD88 mutated cells by a paracrine mechanism
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Blood, 2018-03-01;0(0):. 2018-03-01
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A model combining age, equivalent uniform dose and IL-8 may predict radiation esophagitis in patients with non-small cell lung cancer
Authors: S Wang, J Campbell, MH Stenmark, P Stanton, J Zhao, MM Matuszak, RK Ten Haken, FM Kong
Radiother Oncol, 2018-03-01;0(0):. 2018-03-01
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T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells
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Immunity, 2018-02-20;48(2):327-338.e5. 2018-02-20
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Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor
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Am. J. Pathol., 2018-02-16;0(0):. 2018-02-16
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Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
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Mol. Cell, 2018-02-15;69(4):551-565.e7. 2018-02-15
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Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain
Authors: JM Dave, T Mirabella, SD Weatherbee, DM Greif
Dev. Cell, 2018-02-15;0(0):. 2018-02-15
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Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3K? inhibitors and VIP antagonists
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Blood Adv, 2018-02-13;2(3):210-223. 2018-02-13
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Combinations of antioxidants and/or of epigenetic enzyme inhibitors allow for enhanced collection of mouse bone marrow hematopoietic stem cells in ambient air
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Blood Cells Mol. Dis., 2018-02-13;0(0):. 2018-02-13
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Roles of Ihh signaling in chondroprogenitor function in postnatal condylar cartilage
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Matrix Biol., 2018-02-12;0(0):. 2018-02-12
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Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment
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Retrovirology, 2018-02-01;15(1):17. 2018-02-01
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Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha
Authors: A Kia, K McAvoy, K Krishnamur, D Trotti, P Pasinelli
Glia, 2018-01-30;0(0):. 2018-01-30
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Whole-genome transcriptomic insights into protective molecular mechanisms in metabolically healthy obese African Americans
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NPJ Genom Med, 2018-01-29;3(0):4. 2018-01-29
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Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
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Nat. Med., 2018-01-15;0(0):. 2018-01-15
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Piceatannol-Induced Apoptosis Is Reversed by N-Acetyl-L-cysteine through Restoration of XIAP Expression
Authors: CY Jin, IMN Molagoda, C Park, TK Kwon, SJ Yun, WJ Kim, GY Kim, YH Choi
Biol. Pharm. Bull., 2018-01-01;41(9):1372-1378. 2018-01-01
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Optimization of IL13R?2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma
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Mol. Ther., 2017-10-05;26(1):31-44. 2017-10-05
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Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm.
Authors: Patrick Younan, Mathieu Iampietro, Andrew Nishida, Palaniappan Ramanatha, Rodrigo I Santos, Mukta Dutta, Ndongala Michel Lubaki, Richard A Koup, Michael G Katze, Alexander Bukreyev
MBio, 2017-09-26;0(0):2150-7511. 2017-09-26
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Gpr158 mediates osteocalcin's regulation of cognition
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J. Exp. Med., 2017-08-29;214(10):2859-2873. 2017-08-29
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DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion
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J. Cell Biol., 2017-08-15;216(10):3339-3354. 2017-08-15
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PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients.
Authors: Yuan Zhang, Chi A Ma, Monica G Lawrence, Timothy J Break, Michael P O'connell, Jonathan J Lyons, Diego B López, John S Barber, Yongge Zhao, Daniel L Barber, Alexandra F Freeman, Steven M Holland, Michail S Lionakis, Joshua D Milner
The Journal of Experimental Medicine, 2017-07-14;0(0):1540-9538. 2017-07-14
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Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia
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J. Cell Biol., 2017-06-20;216(8):2581-2596. 2017-06-20
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Aging of bone marrow- and umbilical cord-derived mesenchymal stromal cells during expansion.
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Cytotherapy, 2017-04-24;19(7):798-807. 2017-04-24
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Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not ?-synuclein pathology.
Authors: Douglas G Walker, Lih-Fen Lue, Tiffany M Tang, Charles H Adler, John N Caviness, Marwan N Sabbagh, Geidy E Serrano, Lucia I Sue, Thomas G Beach
Neurobiology of Aging, 2017-03-16;0(0):1558-1497. 2017-03-16
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Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome
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Brain, 2017-03-01;140(3):582-598. 2017-03-01
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A process engineering approach to increase organoid yield
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Development, 2017-02-07;144(6):1128-1136. 2017-02-07
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Restoration of Corneal Transparency by Mesenchymal Stem Cells.
Authors: Sharad K Mittal, Masahiro Omoto, Afsaneh Amouzegar, Anuradha Sahu, Alexandra Rezazadeh, Kishore R Katikired, Dhvanit I Shah, Srikant K Sahu, Sunil K Chauhan
Stem Cell Reports, 2016-09-29;0(0):2213-6711. 2016-09-29
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Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition
J Clin Invest, 2016-07-25;126(8):3130-44. 2016-07-25
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Associations of total and free 25OHD and 1,25(OH)2D with serum markers of inflammation in older men.
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Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the Usa, 2016-02-23;0(0):1433-2965. 2016-02-23
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Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies.
Authors: Rodgers D, Mazagova M, Hampton E, Cao Y, Ramadoss N, Hardy I, Schulman A, Du J, Wang F, Singer O, Ma J, Nunez V, Shen J, Woods A, Wright T, Schultz P, Kim C, Young T
Proc Natl Acad Sci U S A, 2016-01-12;113(4):E459-68. 2016-01-12
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