Myeloperoxidase/MPO Antibody (S07-2C7)

Name: Myeloperoxidase/MPO Antibody (S07-2C7)
Brand: Novus Biologicals
SKU: NBP3-19707
Price: 559 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-19707

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S07-2C7 expressed in HEK293

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Product Specifications

Immunogen

A synthetic peptide of human Myeloperoxidase/MPO (Uniprot # P05164)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Myeloperoxidase/MPO Antibody (S07-2C7)

Western Blot: Myeloperoxidase/MPO Antibody (S07-2C7) [NBP3-19707]

Western Blot: Myeloperoxidase/MPO Antibody (S07-2C7) [NBP3-19707] - Western blot detection of Myeloperoxidase/MPO in 3T3 cell lysates using NBP3-19707 (1:1000 diluted). Predicted band size: 84kDa. Observed band size: 80-90kDa.

Immunohistochemistry-Paraffin: Myeloperoxidase/MPO Antibody (S07-2C7) [NBP3-19707]

Immunohistochemistry-Paraffin: Myeloperoxidase/MPO Antibody (S07-2C7) [NBP3-19707] - Immunohistochemistry of Myeloperoxidase/MPO in paraffin-embedded Human colon cancer tissue using NBP3-19707 at dilution 1/50

Applications for Myeloperoxidase/MPO Antibody (S07-2C7)

Application

Recommended Usage

Immunohistochemistry

1/50-1/200

Western Blot

1/1000-1/5000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Myeloperoxidase/MPO

FUNCTION: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. MPO is an important marker for myeloid cells, from the promyelocyte stage and to the mature forms. CATALYTIC ACTIVITY: Donor + H2O2 = oxidized donor + 2 H2O. CATALYTIC ACTIVITY: Cl- + H2O2 = HOCl + 2 H2O. COFACTOR: Binds 1 calcium ion per heterodimer. COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer. SUBUNIT: Tetramer of two light chains and two heavy chains. SUBCELLULAR LOCATION: Lysosome. ALTERNATIVE PRODUCTS: 3 named isoforms produced by alternative splicing. DISEASE: Defects in MPO are the cause of myeloperoxidase deficiency (MPD). MPD is an autosomal recessive defect that results in disseminated candidiasis. SIMILARITY: Belongs to the peroxidase family. XPO subfamily.

Alternate Names

MPO

Gene Symbol

MPO

Additional Myeloperoxidase/MPO Products

Product Documents for Myeloperoxidase/MPO Antibody (S07-2C7)

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Certificate of Analysis

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Product Specific Notices for Myeloperoxidase/MPO Antibody (S07-2C7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Granulocyte Markers

Inflammatory Mediators

Myeloid Lineage Markers

Neutrophils

Oxidative Stress

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