Naloxone 3-glucuronide carbonic acid salt

Catalog # Availability Size / Price Qty
5684/1
Cat.No. 5684 - Naloxone 3-glucuronide carbonic acid salt | C25H29NO10.H2CO3
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Description: Naloxone conjugate

Chemical Name: (5α)-4,5-Epoxy-14-hydroxy-6-oxo-17-(2-propenyl)morphinan-3-yl β-D-glucopyranosiduronic acid carbonic acid salt

Purity: ≥98%

Product Details
Reviews

Biological Activity

Naloxone conjugate. Following oral administration induces delayed diarrhea, as well as milder and delayed withdrawal behavior and tail skin temperature (TST) response compared with naloxone in morphine-dependent rats.

Technical Data

M.Wt:
565.52
Formula:
C25H29NO10.H2CO3
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates.
    Simpkins et al.
    J.Pharmacol.Exp.Ther., 1988;244:195

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