Naloxone 3-glucuronide carbonic acid salt
Chemical Name: (5α)-4,5-Epoxy-14-hydroxy-6-oxo-17-(2-propenyl)morphinan-3-yl β-D-glucopyranosiduronic acid carbonic acid salt
Biological ActivityNaloxone conjugate. Following oral administration induces delayed diarrhea, as well as milder and delayed withdrawal behavior and tail skin temperature (TST) response compared with naloxone in morphine-dependent rats.
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Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates.
Simpkins et al.
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