Catalog Number: 1075
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
Biological Activity
L-type calcium channel blocker.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Pharmacological reactivity of human epicardial coronary arteries: phasic and tonic responses to vasoconstrictor agents differentiated by nifedipine.
    Stork and Cocks
    Br.J.Pharmacol., 1994;113:1093

The citations listed below are publications that use Tocris products. Selected citations for Nifedipine include:

Showing Results 1 - 10 of 20

  1. N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
    Authors: Lee Et al.
    J Neurosci
  2. Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
    Authors: Armstrong and Drapeau
    Circ Heart Fail
  3. GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
    Authors: Ring Et al.
    PLoS One
  4. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    Mol Brain
  5. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep
  6. Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity.
    Authors: Luoma Et al.
  7. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
    Authors: Landstrom Et al.
    FEMS Immunol Med Microbiol
  8. Mechanistic distinction between activation and inhibition of (Na(+)+K(+))-ATPase-mediated Ca2+ influx in cardiomyocytes.
    Authors: Xu Et al.
    Mol Cells
  9. Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels.
    Authors: Kim and Rhim
    Proc Natl Acad Sci U S A
  10. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
  11. The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
    Authors: Abe Et al.
    Mol Brain
  12. Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
    Authors: Potier Et al.
    Front Aging Neurosci
  13. Ionic currents in intimal cultured synoviocytes from the rabbit.
    Authors: Large Et al.
    Am J Physiol Cell Physiol
  14. Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.
    Authors: Kyriazis Et al.
    J Biol Chem
  15. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
    Authors: Maier Et al.
    J Biol Chem
  16. Two distinct mechanisms mediate potentiating effects of depolarization on synaptic transmission.
    Authors: Ludwar Et al.
    J Neurophysiol
  17. Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
    Authors: Soriano Et al.
    Biochem Biophys Res Commun
  18. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
    Authors: Shin Et al.
    Proc Natl Acad Sci U S A
  19. Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
    Authors: Wieland Et al.
    J Neurosci
  20. Regulation of cpg15 by signaling pathways that mediate synaptic plasticity.
    Authors: Fujino Et al.
    Mol Cell Neurosci
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