Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
Biological ActivityNifedipine is a L-type calcium channel blocker.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological reactivity of human epicardial coronary arteries: phasic and tonic responses to vasoconstrictor agents differentiated by nifed.
Stork and Cocks
Citations for Nifedipine
The citations listed below are publications that use Tocris products. Selected citations for Nifedipine include:
37 Citations: Showing 1 - 10
The Dependence of Urinary Bladder Responses on Extracellular Calcium Varies Between Muscarinic, Histamine, 5-HT (Serotonin), Neurokinin, Prostaglandin, and Angiotensin Receptor Activation
Authors: Phelps Et al.
Front Physiol 2022;13:841181
Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
Authors: Lopez Et al.
Aquaporin-4 Surface Trafficking Regulates Astrocytic Process Motility and Synaptic Activity in Health and Autoimmune Disease.
Authors: Ciappelloni Et al.
Cell Rep 2019;27:3860
Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma.
Authors: Florea Et al.
Molecular basis of ancestral vertebrate electroreception.
Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.
Authors: Mauger Et al.
Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent.
Authors: Hanlon Et al.
Breast Cancer (Dove Med Press) 2016;8:59
Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus.
Authors: Pigott and Garthwaite
Front Synaptic Neurosci 2016;8:17
Hepcidin and 1,25(OH)2D3 effectively restore Ca2+ transport in β-thalassemic mice: reciprocal phenomenon of Fe2+ and Ca2+ absorption.
Authors: Kraidith Et al.
Am J Physiol Endocrinol Metab 2016;311:E214
N-MthD.-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
Authors: Lee Et al.
J Neurosci 2015;8:4
L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner.
Authors: Wang and Mattson
Neurobiol Aging 2014;35:88
Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
Authors: Armstrong and Drapeau
Circ Heart Fail 2013;33:1741
GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
Authors: Ring Et al.
PLoS One 2012;7:e36874
A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes.
Authors: Yang Et al.
J Neurosci 2012;32:7550
Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
Authors: Kaufman Et al.
Mol Brain 2012;32:3992
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Authors: Caiati Et al.
Sci Rep 2012;2:285
Decreased afferent excitability contributes to synaptic depression during high-frequency stimulation in hippocampal area CA1.
Authors: Kim Et al.
J Neurophysiol 2012;108:1965
Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity.
Authors: Luoma Et al.
Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
Authors: Landstrom Et al.
FEMS Immunol Med Microbiol 2011;4:214
Mechanistic distinction between activation and inhibition of (Na(+)+K(+))-ATPase-mediated Ca2+ influx in cardiomyocytes.
Authors: Xu Et al.
Mol Cells 2011;406:200
Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels.
Authors: Kim and Rhim
Proc Natl Acad Sci U S A 2011;32:289
NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
Authors: Zemkova Et al.
The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
Authors: Abe Et al.
Mol Brain 2011;108:12497
Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
Authors: Potier Et al.
Front Aging Neurosci 2010;2:1
Ionic currents in intimal cultured synoviocytes from the rabbit.
Authors: Large Et al.
Am J Physiol Cell Physiol 2010;299:C1180
Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.
Authors: Kyriazis Et al.
J Biol Chem 2010;285:6811
Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
Authors: Maier Et al.
J Biol Chem 2010;285:35606
Non-Hebbian synaptic plasticity induced by repetitive postsynaptic action potentials.
Authors: Kato Et al.
J Neurosci 2009;29:11153
Two distinct mechanisms mediate potentiating effects of depolarization on synaptic transmission.
Authors: Ludwar Et al.
J Neurophysiol 2009;102:1976
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
Authors: Soriano Et al.
Biochem Biophys Res Commun 2008;28:10696
Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
Authors: Shin Et al.
Proc Natl Acad Sci U S A 2008;105:746
Contribution of both Ca2+ entry and Ca2+ sensitization to the alpha1-adrenergic vasoconstriction of rat penile small arteries.
Authors: Villalba Et al.
Am J Physiol Heart Circ Physiol 2007;292:H1157
Synapse specificity of long-term potentiation breaks down with aging.
Authors: Ris and Godaux
Learn Mem 2007;14:185
Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
Authors: Wieland Et al.
J Neurosci 2006;47:296
Adaptation to synaptic inactivity in hippocampal neurons.
Authors: Thiagarajan Et al.
Regulation of cpg15 by signaling pathways that mediate synaptic plasticity.
Authors: Fujino Et al.
Mol Cell Neurosci 2003;24:538
Nifedipine facilitates neurotransmitter release independently of calcium channels.
Proc Natl Acad Sci U S A 2003;100:6139
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