Catalog Number: 1075
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
Biological Activity
L-type calcium channel blocker.
Technical Data
  • M.Wt:
    346.34
  • Formula:
    C17H18N2O6
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    21829-25-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Pharmacological reactivity of human epicardial coronary arteries: phasic and tonic responses to vasoconstrictor agents differentiated by nifedipine.
    Stork and Cocks
    Br.J.Pharmacol., 1994;113:1093
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Nifedipine include:

21 Citations: Showing 1 - 10
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  1. Molecular basis of ancestral vertebrate electroreception.
    Authors: Bellono
    Nature 2017;543:391
  2. N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
    Authors: Lee Et al.
    J Neurosci 2015;8:4
  3. Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
    Authors: Armstrong and Drapeau
    Circ Heart Fail 2013;33:1741
  4. GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
    Authors: Ring Et al.
    PLoS One 2012;7:e36874
  5. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    Mol Brain 2012;32:3992
  6. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep 2012;2:285
  7. Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity.
    Authors: Luoma Et al.
    Steroids 2011;76:845
  8. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
    Authors: Landstrom Et al.
    FEMS Immunol Med Microbiol 2011;4:214
  9. Mechanistic distinction between activation and inhibition of (Na(+)+K(+))-ATPase-mediated Ca2+ influx in cardiomyocytes.
    Authors: Xu Et al.
    Mol Cells 2011;406:200
  10. Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels.
    Authors: Kim and Rhim
    Proc Natl Acad Sci U S A 2011;32:289
  11. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology 2011;152:3842
  12. The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
    Authors: Abe Et al.
    Mol Brain 2011;108:12497
  13. Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
    Authors: Potier Et al.
    Front Aging Neurosci 2010;2:1
  14. Ionic currents in intimal cultured synoviocytes from the rabbit.
    Authors: Large Et al.
    Am J Physiol Cell Physiol 2010;299:C1180
  15. Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.
    Authors: Kyriazis Et al.
    J Biol Chem 2010;285:6811
  16. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
    Authors: Maier Et al.
    J Biol Chem 2010;285:35606
  17. Two distinct mechanisms mediate potentiating effects of depolarization on synaptic transmission.
    Authors: Ludwar Et al.
    J Neurophysiol 2009;102:1976
  18. Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
    Authors: Soriano Et al.
    Biochem Biophys Res Commun 2008;28:10696
  19. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
    Authors: Shin Et al.
    Proc Natl Acad Sci U S A 2008;105:746
  20. Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
    Authors: Wieland Et al.
    J Neurosci 2006;47:296
  21. Regulation of cpg15 by signaling pathways that mediate synaptic plasticity.
    Authors: Fujino Et al.
    Mol Cell Neurosci 2003;24:538
Expand to show all 21 Citations

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