Nifedipine

Tocris Bioscience | Catalog # 1075

CaV1.x blocker
Tocris Bioscience

Key Product Details

Description

CaV1.x blocker
View all Cav1.x Channel Blockers »

Product Description

Nifedipine is a L-type calcium channel blocker.

Product Specifications for Nifedipine

Molecular Weight

346.34

Formula

C17H18N2O6

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester

CAS Number

21829-25-4

PubChem ID

4485

InChI Key

HYIMSNHJOBLJNT-UHFFFAOYSA-N

SMILES

COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1[N+]([O-])=O)C(=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.63 100

Preparing Stock Solutions for Nifedipine

The following data is based on the product molecular weight 346.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.44 mL 28.87 mL
5 mM 0.58 mL 2.89 mL 5.77 mL
10 mM 0.29 mL 1.44 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 270 publications citing the usage of this product.

Product Documents for Nifedipine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Nifedipine

For research use only

⚠ WARNING: This product can expose you to chemicals including Nifedipine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Nifedipine (5)

4.8 out of 5
5 Customer Ratings
5 Stars
80%
4 Stars
20%
3 Stars
0%
2 Stars
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1 Stars
0%

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Showing  1 - 5 of 5 reviews Showing All
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  • breast cancer cell viability by a cannabinoid receptor 2 agonist
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: MCF-7
    Verified Customer | Posted 03/15/2020
    We used all these compounds which were dissolved in DMSO and added to fresh culture media. Concentration reference paper PMID: 27186076
    Nifedipine 1075
  • The pharmacological inhibitors for electrophysiology assay
    Name: Anonymous
    Species: skate
    Assay Type: In Vitro
    Verified Customer | Posted 02/28/2020
    The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.
    Nifedipine 1075
  • Blocks L type calcium entry in neurons
    Name: Karthik krishnamurthy
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: spinal cord neurons
    Verified Customer | Posted 11/02/2018
    Effectively blocks KCL mediated L type calcium entry in neurons. Tested in spinal cord neuron cultures at a concentration of 10 micromolar.
    Nifedipine 1075
  • Nifedipine blocks L-type Ca2+ current in primary cardiomyoytes
    Name: Chintan Koyani
    Species: Guinea Pig
    Assay Type: In Vitro
    Cell Line/Tissue: Primary ventricular cardiomyocytes
    Verified Customer | Posted 10/23/2018
    L-type Ca2+ current of guinea pig cardiomyocytes before and after nifedipine (1 µM) superfusion for 5 min. Compared to time-matched rundown, nifedipine significantly blocked L-type Ca2+ current in cardiomyocytes
    Nifedipine 1075
  • Applied to GI smooth muscle in tissue bath
    Name: John Broad
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 01/05/2018
    Effective calcium channel blocker
    Applied to human GI smooth muscle

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