Nifedipine

  ( 28 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1075
Chemical Name:1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
Product Details
Citations (28)
Reviews
Biological Activity
L-type calcium channel blocker.
Technical Data
  • M.Wt:
    346.34
  • Formula:
    C17H18N2O6
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    21829-25-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Nifedipine include:

28 Citations: Showing 1 - 10
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  1. Molecular basis of ancestral vertebrate electroreception.
    Authors: Bellono
    Nature  2017;543:391
  2. Hepcidin and 1,25(OH)2D3 effectively restore Ca2+ transport in β-thalassemic mice: reciprocal phenomenon of Fe2+ and Ca2+ absorption.
    Authors: Kraidith Et al.
    Am J Physiol Endocrinol Metab  2016;311:E214
  3. N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
    Authors: Lee Et al.
    J Neurosci  2015;8:4
  4. L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner.
    Authors: Wang and Mattson
    Neurobiol Aging  2014;35:88
  5. Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
    Authors: Armstrong and Drapeau
    Circ Heart Fail  2013;33:1741
  6. GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
    Authors: Ring Et al.
    PLoS One  2012;7:e36874
  7. A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes.
    Authors: Yang Et al.
    J Neurosci  2012;32:7550
  8. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    Mol Brain  2012;32:3992
  9. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep  2012;2:285
  10. Decreased afferent excitability contributes to synaptic depression during high-frequency stimulation in hippocampal area CA1.
    Authors: Kim Et al.
    J Neurophysiol  2012;108:1965
  11. Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity.
    Authors: Luoma Et al.
    Steroids  2011;76:845
  12. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
    Authors: Landstrom Et al.
    FEMS Immunol Med Microbiol  2011;4:214
  13. Mechanistic distinction between activation and inhibition of (Na(+)+K(+))-ATPase-mediated Ca2+ influx in cardiomyocytes.
    Authors: Xu Et al.
    Mol Cells  2011;406:200
  14. Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels.
    Authors: Kim and Rhim
    Proc Natl Acad Sci U S A  2011;32:289
  15. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology  2011;152:3842
  16. The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
    Authors: Abe Et al.
    Mol Brain  2011;108:12497
  17. Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
    Authors: Potier Et al.
    Front Aging Neurosci  2010;2:1
  18. Ionic currents in intimal cultured synoviocytes from the rabbit.
    Authors: Large Et al.
    Am J Physiol Cell Physiol  2010;299:C1180
  19. Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.
    Authors: Kyriazis Et al.
    J Biol Chem  2010;285:6811
  20. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
    Authors: Maier Et al.
    J Biol Chem  2010;285:35606
  21. Two distinct mechanisms mediate potentiating effects of depolarization on synaptic transmission.
    Authors: Ludwar Et al.
    J Neurophysiol  2009;102:1976
  22. Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
    Authors: Soriano Et al.
    Biochem Biophys Res Commun  2008;28:10696
  23. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
    Authors: Shin Et al.
    Proc Natl Acad Sci U S A  2008;105:746
  24. Contribution of both Ca2+ entry and Ca2+ sensitization to the alpha1-adrenergic vasoconstriction of rat penile small arteries.
    Authors: Villalba Et al.
    Am J Physiol Heart Circ Physiol  2007;292:H1157
  25. Synapse specificity of long-term potentiation breaks down with aging.
    Authors: Ris and Godaux
    Learn Mem  2007;14:185
  26. Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
    Authors: Wieland Et al.
    J Neurosci  2006;47:296
  27. Adaptation to synaptic inactivity in hippocampal neurons.
    Authors: Thiagarajan Et al.
    Neuron  2005;47:725
  28. Regulation of cpg15 by signaling pathways that mediate synaptic plasticity.
    Authors: Fujino Et al.
    Mol Cell Neurosci  2003;24:538
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  Human John Broad 01/05/2018
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Species Human

Other Experimental Details

Other Experimental Details Effective calcium channel blocker

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