NLRP1/NALP1 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-76656

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all NLRP1/NALP1 Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against a peptide corresponding to 13 amino acids near the carboxy terminus of human NALP1. The immunogen is located within the last 50 amino acids of NALP1.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NLRP1/NALP1 Antibody - BSA Free

Western Blot: NLRP1/NALP1 AntibodyBSA Free [NBP1-76656]

Western Blot: NLRP1/NALP1 AntibodyBSA Free [NBP1-76656]

Western Blot: NLRP1/NALP1 Antibody [NBP1-76656] - U937 cell lysate with NALP1 antibody at (A) 1, (B) 2 and (C) 4 ug/ml.
NLRP1/NALP1 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: NLRP1/NALP1 Antibody - BSA Free [NBP1-76656] -

Immunocytochemistry/ Immunofluorescence: NLRP1/NALP1 Antibody - BSA Free [NBP1-76656] - Immunofluorescence of NLRP1/NALP1 in K562 cells with NLRP1/NALP1 antibody at 20 ug/mL.
NLRP1/NALP1 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: NLRP1/NALP1 Antibody - BSA Free [NBP1-76656] -

Immunocytochemistry/ Immunofluorescence: NLRP1/NALP1 Antibody - BSA Free [NBP1-76656] - Immunocytochemistry of NLRP1/NALP1 in K562 cells with NLRP1/NALP1 antibody at 10 ug/mL.

Applications for NLRP1/NALP1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

10-20 ug/mL

Western Blot

1-4 ug/ml

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NLRP1/NALP1

NALP1 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. It contains a caspase recruitment domain (CARD) in addition to a NACHT domain and leucine rich repeat (LRR). This protein interacts strongly with caspase 2 and weakly with caspase 9, as well as with Apaf-1. Transient overexpression of this gene in cultured cells was sufficient to induce apoptosis. NALP1 mRNA and protein expression levels in myeloid leukemia cells are increased following CREB (cAMP-response element binding protein) activation, suggesting that NALP1 may contribute to modulate the response of these cells to pro-inflammatory stimuli. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for NALP1.

Long Name

NLR Family, Pyrin Domain Containing 1

Alternate Names

CARD7, CLR17.1, DEFCAP, NALP1, PP1044, SLEV1, VAMAS1

Gene Symbol

NLRP1

UniProt

AAG30288 (Human)

Additional NLRP1/NALP1 Products

Product Documents for NLRP1/NALP1 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for NLRP1/NALP1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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Associated Pathways

NOD-like Receptor Signaling Pathways NOD-like Receptor Signaling Pathway Thumbnail