Notch-2 Antibody - BSA Free

Name: Notch-2 Antibody - BSA Free
Brand: Novus Biologicals
SKU: NB100-93549
Price: 169 USD
Availability: InStock

Novus Biologicals | Catalog # NB100-93549

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Product Documents

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (91%), Rat (92%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Western Blot, ELISA

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

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Product Specifications

Immunogen

Synthetic peptide representing the C terminal region of the human NOTCH homolog 2 (NOTCH2) protein.

Specificity

Notch 2 homolog

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Notch-2 Antibody - BSA Free

Application

Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

1:10-1:500

Western Blot

1:100-1:2000

Application Notes

This antibody is useful for Western Blot, ELISA and immunohistochemistry.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Notch-2

Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.

Alternate Names

Notch2

Entrez Gene IDs

4853 (Human)

Gene Symbol

NOTCH2

Additional Notch-2 Products

Product Documents for Notch-2 Antibody - BSA Free

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Product Specific Notices for Notch-2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.