Cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (Ki
values are 5 and 12 μ
M respectively). Inhibits growth of human tumor cells in vitro
= 13 μ
M). Also inhibits DNA topoisomerase II ATPase activity (IC50
= 300 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.
Arris et al.
Pharmacological inhibitors of cyclin-dependent kinases.
Knockaert et al.
Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors.
Jensen et al.
Cancer Res., 2005;65:7470
The citations listed below are publications that use Tocris products. Selected citations for NU 2058 include:
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