Chemical Name: 6-(Cyclohexylmethoxy)-9H-purin-2-amine
Biological ActivityNU 2058 is a cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (Ki values are 5 and 12 μM respectively). Inhibits growth of human tumor cells in vitro (mean GI50 = 13 μM). Also inhibits DNA topoisomerase II ATPase activity (IC50 = 300 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.
Arris et al.
Pharmacological inhibitors of cyclin-dependent kinases.
Knockaert et al.
Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors.
Jensen et al.
Cancer Res., 2005;65:7470
Citation for NU 2058
The citations listed below are publications that use Tocris products. Selected citations for NU 2058 include:
1 Citation: Showing 1 - 1
A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers.
Authors: Goonesekere Et al.
PLoS One 2014;9:e93046
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