Catalog Number: 3135
Chemical Name: 6-(Cyclohexylmethoxy)-9H-purin-2-amine
Biological Activity
Cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (Ki values are 5 and 12 μM respectively). Inhibits growth of human tumor cells in vitro (mean GI50 = 13 μM). Also inhibits DNA topoisomerase II ATPase activity (IC50 = 300 μM).
Technical Data
  • M.Wt:
    247.3
  • Formula:
    C12H17N5O
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    161058-83-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.
    Arris et al.
    J.Med.Chem., 2000;43:2797
  2. Pharmacological inhibitors of cyclin-dependent kinases.
    Knockaert et al.
    TiPS, 2002;23:417
  3. Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors.
    Jensen et al.
    Cancer Res., 2005;65:7470
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NU 2058 include:

1 Citations: Showing 1 - 1

  1. A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers.
    Authors: Goonesekere Et al.
    PLoS One 2014;9:e93046

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