NVP DPP 728 dihydrochloride

Catalog # Availability Size / Price Qty
3506/10
3506/50
NVP DPP 728 dihydrochloride | CAS No. 207556-62-5 | DPPIV/CD26 Inhibitors
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Description: Potent, orally active dipeptidyl peptidase IV (DPP-IV) inhibitor

Chemical Name: 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile dihydrochloride

Purity: ≥97%

Product Details
Citations (1)
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Biological Activity

Potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor (Ki = 11 nM, IC50 = 14 nM) that displays > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Exhibits antidiabetic activity in vivo; improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, augments insulin secretion and GLUT2 levels, and reduces (preserves) islet size.

Technical Data

M.Wt:
371.27
Formula:
C15H18N6O.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
207556-62-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for NVP DPP 728 dihydrochloride

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