NVP DPP 728 dihydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:3506
Chemical Name:6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile dihydrochloride
Product Details
Citations (1)
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Biological Activity
Potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor (Ki = 11 nM, IC50 = 14 nM) that displays > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Exhibits antidiabetic activity in vivo; improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, augments insulin secretion and GLUT2 levels, and reduces (preserves) islet size.
Technical Data
  • M.Wt:
    371.27
  • Formula:
    C15H18N6O.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    207556-62-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NVP DPP 728 dihydrochloride include:

1 Citations: Showing 1 - 1

  1. Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum.
    Authors: Inoue Et al.
    Stem Cell Reports  2012;303:G810

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