PARP Enzyme High Specific Activity

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Product Details
Citations (20)

PARP Enzyme High Specific Activity Summary

Purified from E. coli containing a recombinant plasmid harboring human PARP1 gene.

Key Benefits

• Identification of inhibitors of PARP1 activity Quantitation of DNA Damage Investigation of PARP1 inactivation during apoptosis Western Blot Analysis

Substrate Specificity

PARP1 uses NAD+ as a substrate to catalyze poly(ADP-ribosyl)ation of target proteins involved  in  chromatin  structure  and  DNA  metabolism. PARP1 is stimulated by DNA-strand breaks and capable of auto-ribosylation.


10 units/µl


Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.


For research use only. Not for diagnostic use.

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Citations for PARP Enzyme High Specific Activity

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

20 Citations: Showing 1 - 10
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  1. PARP1 associates with R-loops to promote their resolution and genome stability
    Authors: N Laspata, P Kaur, SY Mersaoui, D Muoio, ZS Liu, MH Bannister, HD Nguyen, C Curry, JM Pascal, GG Poirier, H Wang, JY Masson, E Fouquerel
    Nucleic Acids Research, 2023-03-21;0(0):.  2023-03-21
  2. Inhibition of poly (ADP-ribose) Polymerase-1 (PARP-1) improves endothelial function in pulmonary hypertension
    Authors: M Shafiq, ZR Lone, AO Abdulkaree, G Kaur, S Navya, H Singh, K Jagavelu, K Hanif
    Pulmonary pharmacology & therapeutics, 2023-02-25;0(0):102200.  2023-02-25
  3. BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer
    Authors: Y Zhang, M Fang, S Li, H Xu, J Ren, L Tu, B Zuo, W Yao, G Liang
    Molecular Cancer, 2022-08-02;21(1):158.  2022-08-02
  4. Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling
    Authors: M Nagy-Pénze, Z Hajnády, Z Regdon, MÁ Demény, K Kovács, T El-Hamoly, J Maléth, P Hegyi, C Heged?s, L Virág
    Biomedicines, 2022-06-10;10(6):.  2022-06-10
  5. PARP Inhibitor Decreases Akt Phosphorylation and Induces Centrosome Amplification and Chromosomal Aneuploidy in CHO-K1 Cells
    Authors: M Tanaka, M Mushiake, J Takahashi, Y Sasaki, S Yamashita, C Ida, M Masutani, M Miwa
    International Journal of Molecular Sciences, 2022-03-23;23(7):.  2022-03-23
  6. XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair
    Authors: M Adamowicz, R Hailstone, AA Demin, E Komulainen, H Hanzlikova, J Brazina, A Gautam, SE Wells, KW Caldecott
    Nature Cell Biology, 2021-11-22;0(0):.  2021-11-22
  7. Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors
    Authors: A Hsieh, JR Pitarresi, J Lerner, G Donahue, D Hsiehchen, AK Rustgi, K Zaret
    Science Advances, 2020-12-04;6(49):.  2020-12-04
  8. PARP1 Deficiency Reduces Tumour Growth by Decreasing E2F1 Hyperactivation: A Novel Mechanism in the Treatment of Cancer
    Authors: P Iglesias, M Seoane, I Golán, I Castro-Pie, M Fraga, VM Arce, JA Costoya
    Cancers (Basel), 2020-10-10;12(10):.  2020-10-10
  9. Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.
    Authors: Talhaoui I, Lebedeva N, Zarkovic G, Saint-Pierre C, Kutuzov M, Sukhanova M, Matkarimov B, Gasparutto D, Saparbaev M, Lavrik O, Ishchenko A
    Nucleic Acids Res, 2016-07-28;44(19):9279-9295.  2016-07-28
  10. The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose).
    Authors: Silva A, Ryan D, Galanty Y, Low J, Vandevenne M, Jackson S, MacKay J
    J Biol Chem, 2015-11-12;291(2):924-38.  2015-11-12
  11. Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities.
    Authors: Khadka P, Hsu J, Veith S, Tadokoro T, Shamanna R, Mangerich A, Croteau D, Bohr V
    Mol Cell Biol, 2015-09-21;35(23):3974-89.  2015-09-21
  12. An LRP16-containing preassembly complex contributes to NF-kappaB activation induced by DNA double-strand breaks.
    Authors: Wu Z, Wang C, Bai M, Li X, Mei Q, Li X, Wang Y, Fu X, Luo G, Han W
    Nucleic Acids Res, 2015-03-03;43(6):3167-79.  2015-03-03
  13. Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.
    Authors: Li N, Zhang Y, Han X, Liang K, Wang J, Feng L, Wang W, Songyang Z, Lin C, Yang L, Yu Y, Chen J
    Genes Dev, 2014-12-29;29(2):157-70.  2014-12-29
  14. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
    Authors: Khoury-Haddad H, Guttmann-Raviv N, Ipenberg I, Huggins D, Jeyasekharan A, Ayoub N
    Proc Natl Acad Sci U S A, 2014-02-03;111(7):E728-37.  2014-02-03
  15. Molecular tweezers with varying anions: a comparative study.
    Authors: Dutt S, Wilch C, Gersthagen T, Talbiersky P, Bravo-Rodriguez K, Hanni M, Sanchez-Garcia E, Ochsenfeld C, Klarner F, Schrader T
    J Org Chem, 2013-06-18;78(13):6721-34.  2013-06-18
  16. 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
    Authors: MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson J, Matthews J
    Nucleic Acids Res, 2012-12-28;41(3):1604-21.  2012-12-28
  17. Activation of the SNF2 family ATPase ALC1 by poly(ADP-ribose) in a stable ALC1.PARP1.nucleosome intermediate.
    Authors: Gottschalk A, Trivedi R, Conaway J, Conaway R
    J Biol Chem, 2012-11-06;287(52):43527-32.  2012-11-06
  18. Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair.
    Authors: King B, Cooper K, Liu K, Hudson L
    J Biol Chem, 2012-10-04;287(47):39824-33.  2012-10-04
  19. CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells.
    Authors: Wright R, Castellano G, Bonet J, Le Dily F, Font-Mateu J, Ballare C, Nacht A, Soronellas D, Oliva B, Beato M
    Genes Dev, 2012-09-01;26(17):1972-83.  2012-09-01
  20. Homogeneous screening assay for human tankyrase.
    Authors: Narwal M, Fallarero A, Vuorela P, Lehtio L
    J Biomol Screen, 2012-02-21;17(5):593-604.  2012-02-21


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