PARP Enzyme High Specific Activity

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Product Details
Citations (15)

PARP Enzyme High Specific Activity Summary

Purified from E. coli containing a recombinant plasmid harboring human PARP1 gene.

Key Benefits

• Identification of inhibitors of PARP1 activity Quantitation of DNA Damage Investigation of PARP1 inactivation during apoptosis Western Blot Analysis

Substrate Specificity

PARP1 uses NAD+ as a substrate to catalyze poly(ADP-ribosyl)ation of target proteins involved  in  chromatin  structure  and  DNA  metabolism. PARP1 is stimulated by DNA-strand breaks and capable of auto-ribosylation.


10 units/µl


Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.


For research use only. Not for diagnostic use.

Product Datasheets

Citations for PARP Enzyme High Specific Activity

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

15 Citations: Showing 1 - 10
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  1. XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair
    Authors: M Adamowicz, R Hailstone, AA Demin, E Komulainen, H Hanzlikova, J Brazina, A Gautam, SE Wells, KW Caldecott
    Nature Cell Biology, 2021;0(0):.  2021
  2. Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors
    Authors: A Hsieh, JR Pitarresi, J Lerner, G Donahue, D Hsiehchen, AK Rustgi, K Zaret
    Science Advances, 2020;6(49):.  2020
  3. PARP1 Deficiency Reduces Tumour Growth by Decreasing E2F1 Hyperactivation: A Novel Mechanism in the Treatment of Cancer
    Authors: P Iglesias, M Seoane, I Golán, I Castro-Pie, M Fraga, VM Arce, JA Costoya
    Cancers (Basel), 2020;12(10):.  2020
  4. Homogeneous screening assay for human tankyrase.
    Authors: Narwal M, Fallarero A, Vuorela P, Lehtio L
    J Biomol Screen, 0;17(5):593-604.  0
  5. Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.
    Authors: Talhaoui I, Lebedeva N, Zarkovic G, Saint-Pierre C, Kutuzov M, Sukhanova M, Matkarimov B, Gasparutto D, Saparbaev M, Lavrik O, Ishchenko A
    Nucleic Acids Res, 0;44(19):9279-9295.  0
  6. Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair.
    Authors: King B, Cooper K, Liu K, Hudson L
    J Biol Chem, 0;287(47):39824-33.  0
  7. Molecular tweezers with varying anions: a comparative study.
    Authors: Dutt S, Wilch C, Gersthagen T, Talbiersky P, Bravo-Rodriguez K, Hanni M, Sanchez-Garcia E, Ochsenfeld C, Klarner F, Schrader T
    J Org Chem, 0;78(13):6721-34.  0
  8. An LRP16-containing preassembly complex contributes to NF-kappaB activation induced by DNA double-strand breaks.
    Authors: Wu Z, Wang C, Bai M, Li X, Mei Q, Li X, Wang Y, Fu X, Luo G, Han W
    Nucleic Acids Res, 0;43(6):3167-79.  0
  9. Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.
    Authors: Li N, Zhang Y, Han X, Liang K, Wang J, Feng L, Wang W, Songyang Z, Lin C, Yang L, Yu Y, Chen J
    Genes Dev, 0;29(2):157-70.  0
  10. 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
    Authors: MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson J, Matthews J
    Nucleic Acids Res, 0;41(3):1604-21.  0
  11. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
    Authors: Khoury-Haddad H, Guttmann-Raviv N, Ipenberg I, Huggins D, Jeyasekharan A, Ayoub N
    Proc Natl Acad Sci U S A, 0;111(7):E728-37.  0
  12. CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells.
    Authors: Wright R, Castellano G, Bonet J, Le Dily F, Font-Mateu J, Ballare C, Nacht A, Soronellas D, Oliva B, Beato M
    Genes Dev, 0;26(17):1972-83.  0
  13. Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities.
    Authors: Khadka P, Hsu J, Veith S, Tadokoro T, Shamanna R, Mangerich A, Croteau D, Bohr V
    Mol Cell Biol, 0;35(23):3974-89.  0
  14. The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose).
    Authors: Silva A, Ryan D, Galanty Y, Low J, Vandevenne M, Jackson S, MacKay J
    J Biol Chem, 0;291(2):924-38.  0
  15. Activation of the SNF2 family ATPase ALC1 by poly(ADP-ribose) in a stable ALC1.PARP1.nucleosome intermediate.
    Authors: Gottschalk A, Trivedi R, Conaway J, Conaway R
    J Biol Chem, 0;287(52):43527-32.  0


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