PARP Enzyme High Specific Activity
PARP Enzyme High Specific Activity Summary
• Identification of inhibitors of PARP1 activity Quantitation of DNA Damage Investigation of PARP1 inactivation during apoptosis Western Blot Analysis
PARP1 uses NAD+ as a substrate to catalyze poly(ADP-ribosyl)ation of target proteins involved in chromatin structure and DNA metabolism. PARP1 is stimulated by DNA-strand breaks and capable of auto-ribosylation.
For research use only. Not for diagnositic use.
Citations for PARP Enzyme High Specific Activity
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Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors
Authors: A Hsieh, JR Pitarresi, J Lerner, G Donahue, D Hsiehchen, AK Rustgi, K Zaret
Science Advances, 2020;6(49):. 2020
Homogeneous screening assay for human tankyrase.
Authors: Narwal M, Fallarero A, Vuorela P, Lehtio L
J Biomol Screen, 0;17(5):593-604. 0
Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.
Authors: Talhaoui I, Lebedeva N, Zarkovic G, Saint-Pierre C, Kutuzov M, Sukhanova M, Matkarimov B, Gasparutto D, Saparbaev M, Lavrik O, Ishchenko A
Nucleic Acids Res, 0;44(19):9279-9295. 0
Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair.
Authors: King B, Cooper K, Liu K, Hudson L
J Biol Chem, 0;287(47):39824-33. 0
Molecular tweezers with varying anions: a comparative study.
Authors: Dutt S, Wilch C, Gersthagen T, Talbiersky P, Bravo-Rodriguez K, Hanni M, Sanchez-Garcia E, Ochsenfeld C, Klarner F, Schrader T
J Org Chem, 0;78(13):6721-34. 0
An LRP16-containing preassembly complex contributes to NF-kappaB activation induced by DNA double-strand breaks.
Authors: Wu Z, Wang C, Bai M, Li X, Mei Q, Li X, Wang Y, Fu X, Luo G, Han W
Nucleic Acids Res, 0;43(6):3167-79. 0
Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.
Authors: Li N, Zhang Y, Han X, Liang K, Wang J, Feng L, Wang W, Songyang Z, Lin C, Yang L, Yu Y, Chen J
Genes Dev, 0;29(2):157-70. 0
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
Authors: MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson J, Matthews J
Nucleic Acids Res, 0;41(3):1604-21. 0
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
Authors: Khoury-Haddad H, Guttmann-Raviv N, Ipenberg I, Huggins D, Jeyasekharan A, Ayoub N
Proc Natl Acad Sci U S A, 0;111(7):E728-37. 0
CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells.
Authors: Wright R, Castellano G, Bonet J, Le Dily F, Font-Mateu J, Ballare C, Nacht A, Soronellas D, Oliva B, Beato M
Genes Dev, 0;26(17):1972-83. 0
Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities.
Authors: Khadka P, Hsu J, Veith S, Tadokoro T, Shamanna R, Mangerich A, Croteau D, Bohr V
Mol Cell Biol, 0;35(23):3974-89. 0
The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose).
Authors: Silva A, Ryan D, Galanty Y, Low J, Vandevenne M, Jackson S, MacKay J
J Biol Chem, 0;291(2):924-38. 0
Activation of the SNF2 family ATPase ALC1 by poly(ADP-ribose) in a stable ALC1.PARP1.nucleosome intermediate.
Authors: Gottschalk A, Trivedi R, Conaway J, Conaway R
J Biol Chem, 0;287(52):43527-32. 0
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