PD 180970

Catalog # Availability Size / Price Qty
4965/10
PD 180970 | CAS No. 287204-45-9 | Abl Kinase Inhibitors
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Description: p210Bcr/Abl kinase inhibitor; also inhibits c-Src and KIT

Chemical Name: 6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one

Purity: ≥98%

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Biological Activity

ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells. Inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50 values are 80, 80 and 170 nM respectively). Potently inhibits p210bcr/abl autophosphorylation in vitro (IC50 = 5 nM). Also potently inhibits c-Src and KIT (IC50 values are 0.8 and 50 nM, respectively).

Technical Data

M.Wt:
429.27
Formula:
C21H15Cl2FN4O
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
287204-45-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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