Peptide inhibitor of the interaction between the C-terminus of the GluR2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces postsynaptic currents in CA1 neurons, AMPA-mediated currents in cultured hippocampal neurons and AMPA receptor surface expression. Control peptide pep4c
(Cat. No. 1596) also available.
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All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Role of AMPA receptor cycling in synaptic transmission and plasticity.
L?scher et al.
Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism.
Noel et al.
NSF binding to GluR2 regulates synaptic transmission.
Nishimune et al.
Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction.
Luthi et al.
Functional roles of protein interactions with AMPA and kainate receptors.
Collingridge and Isaac
The citations listed below are publications that use Tocris products. Selected citations for pep2m include:
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