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PEPA

Catalog #: 2929 Datasheet / COA / SDS

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2929 has been discontinued.
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PEPA | CAS No. 141286-78-4 | AMPA Receptor Modulators
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Description: Allosteric potentiator of AMPA receptor desensitization

Chemical Name: 2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide

Purity: ≥99%

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Biological Activity

Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluA3/4 > GluA1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.

Technical Data

M.Wt:
402.44
Formula:
C16H16F2N2O4S2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
141286-78-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A novel allosteric potentiator of AMPA receptors: 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide.
    Sekiguchi et al.
    J.Neurosci., 1997;17:5760
  2. A desensitization-selective potentiator of AMPA-type glutamate receptors.
    Sekiguchi et al.
    Br.J.Pharmacol., 2002;136:1033
  3. The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment.
    Sekiguchi et al.
    Neuroreport, 2001;12:2974

Product Datasheets

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