Catalog Number: 2929
Chemical Name: 2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide
Biological Activity
Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A novel allosteric potentiator of AMPA receptors: 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide.
    Sekiguchi et al.
    J.Neurosci., 1997;17:5760
  2. A desensitization-selective potentiator of AMPA-type glutamate receptors.
    Sekiguchi et al.
    Br.J.Pharmacol., 2002;136:1033
  3. The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment.
    Sekiguchi et al.
    Neuroreport, 2001;12:2974
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