Catalog Number: 3097
Biological Activity
Bacterial toxin that catalyzes ADP-ribosylation of G-proteins Gi, Go and Gt. Impairs G protein heterotrimer interaction with receptors, blocking receptor coupling.
Technical Data
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Indentification of the predominant substrate for ADP-ribosylation by islet activating protein.
    Bokoch et al.
    J.Biol.Chem., 1983;258:2072
  2. ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin.
    Barbieri and Cortina
    Infect.Immun., 1988;56:1934
  3. G protein βγ subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of a subunits by pertussis toxin but differential interactions with Gsa.
    Casey et al.
    Biochemistry, 1989;28:611

The citations listed below are publications that use Tocris products. Selected citations for Pertussis Toxin include:

Showing Results 1 - 10 of 12

  1. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
    Authors: Yuan Et al.
    Am J Physiol Heart Circ Physiol
  2. A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocyanine green dye.
    Authors: Sim Et al.
    Int J Cancer
  3. Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica.
    Authors: Jones Et al.
    Acta Neuropathol Commun
  4. SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II.
    Authors: Choi Et al.
    J Neurosci
  5. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
    Authors: Stott Et al.
    Dis Model Mech
  6. Protein z exerts pro-angiogenic effects and upregulates CXCR4.
    Authors: Butschkau Et al.
    PLoS One
  7. Tissue-resident exhausted effector memory CD8+ T cells accumulate in the retina during chronic experimental autoimmune uveoretinitis.
    Authors: Boldison Et al.
    J Immunol
  8. Cytoskeletal role in protection of the failing heart by β-adrenergic blockade.
    Authors: Cheng Et al.
    Proc Natl Acad Sci U S A
  9. Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity.
    Authors: Wydeven Et al.
    Proc Natl Acad Sci U S A
  10. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.
    Authors: Park Et al.
  11. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem
  12. Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic β2-adrenoceptor activation.
    Authors: Nagaraja Et al.
    Nat Commun
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