Catalog Number: 3097
Biological Activity
Bacterial toxin that catalyzes ADP-ribosylation of G-proteins Gi, Go and Gt. Impairs G protein heterotrimer interaction with receptors, blocking receptor coupling.
Technical Data
  • Storage:
    Store at +4°C
  • CAS No:
    70323-44-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Indentification of the predominant substrate for ADP-ribosylation by islet activating protein.
    Bokoch et al.
    J.Biol.Chem., 1983;258:2072
  2. ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin.
    Barbieri and Cortina
    Infect.Immun., 1988;56:1934
  3. G protein βγ subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of a subunits by pertussis toxin but differential interactions with Gsa.
    Casey et al.
    Biochemistry, 1989;28:611
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pertussis Toxin include:

12 Citations: Showing 1 - 10
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  1. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
    Authors: Yuan Et al.
    Am J Physiol Heart Circ Physiol 2016;7:11024
  2. A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocyanine green dye.
    Authors: Sim Et al.
    Int J Cancer 2015;8:1479
  3. Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica.
    Authors: Jones Et al.
    Acta Neuropathol Commun 2015;3:28
  4. SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II.
    Authors: Choi Et al.
    J Neurosci 2015;136:E219
  5. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
    Authors: Stott Et al.
    Dis Model Mech 2015;112:6497
  6. Protein z exerts pro-angiogenic effects and upregulates CXCR4.
    Authors: Butschkau Et al.
    PLoS One 2014;9:e113554
  7. Tissue-resident exhausted effector memory CD8+ T cells accumulate in the retina during chronic experimental autoimmune uveoretinitis.
    Authors: Boldison Et al.
    J Immunol 2014;192:4541
  8. Cytoskeletal role in protection of the failing heart by β-adrenergic blockade.
    Authors: Cheng Et al.
    Proc Natl Acad Sci U S A 2012;302:H675
  9. Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity.
    Authors: Wydeven Et al.
    Proc Natl Acad Sci U S A 2012;109:21492
  10. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.
    Authors: Park Et al.
    Neuron 2011;31:18433
  11. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem 2011;116:984
  12. Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic β2-adrenoceptor activation.
    Authors: Nagaraja Et al.
    Nat Commun 1999;127:1099
Expand to show all 12 Citations
Average Rating: 5 (Based on 1 review)

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