Biological ActivityPertussis Toxin is a bacterial toxin that catalyzes ADP-ribosylation of G-proteins Gi, Go and Gt. Impairs G protein heterotrimer interaction with receptors, blocking receptor coupling.
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Indentification of the predominant substrate for ADP-ribosylation by islet activating protein.
Bokoch et al.
ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin.
Barbieri and Cortina
G protein βγ subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of a subunits by pertussis toxin but differential interactions with Gsa.
Casey et al.
Citations for Pertussis Toxin
The citations listed below are publications that use Tocris products. Selected citations for Pertussis Toxin include:
19 Citations: Showing 1 - 10
Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro.
Authors: Nepomuceno Et al.
Front Pharmacol 2018;9:157
Selective modulation of tonically active GABAA receptor functional subgroups by G-proteins and protein kinase C.
Authors: O'Neill & Sylantyev
Exp Biol Med (Maywood) 2018;243:1046
Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and Ca2.
Authors: Zhao Et al.
Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression.
Authors: Li Et al.
Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
Authors: Yuan Et al.
Am J Physiol Heart Circ Physiol 2016;7:11024
A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocy. green dye.
Authors: Sim Et al.
Int J Cancer 2015;8:1479
Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica.
Authors: Jones Et al.
Acta Neuropathol Commun 2015;3:28
SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II.
Authors: Choi Et al.
J Neurosci 2015;136:E219
G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
Authors: Stott Et al.
Dis Model Mech 2015;112:6497
The role of lipoprotein-associated phospholipase A2 in a murine model of experimental autoimmune uveoretinitis.
Authors: Crawford Et al.
PLoS One 2015;10:e0122093
Protein z exerts pro-angiogenic effects and upregulates CXCR4.
Authors: Butschkau Et al.
PLoS One 2014;9:e113554
Tissue-resident exhausted effector memory CD8+ T cells accumulate in the retina during chronic experimental autoimmune uveoretinitis.
Authors: Boldison Et al.
J Immunol 2014;192:4541
Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death.
Authors: Rimmerman Et al.
Cell Death Dis 2013;4:e949
Cytoskeletal role in protection of the failing heart by β-adrenergic blockade.
Authors: Cheng Et al.
Proc Natl Acad Sci U S A 2012;302:H675
Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity.
Authors: Wydeven Et al.
Proc Natl Acad Sci U S A 2012;109:21492
Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.
Authors: Park Et al.
Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.
Authors: Schutsky Et al.
J Neurosci 2011;31:14172
β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
Authors: Meitzen Et al.
J Neurochem 2011;116:984
Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic β2-adrenoceptor activation.
Authors: Nagaraja Et al.
Nat Commun 1999;127:1099
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Reviews for Pertussis Toxin
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Pertussis toxin (PeTX) was used to compare effects of PKA and G-protein signalling on root mean square noise (RMS) produced by GABA-A receptors in electrophysiological recording. We found that after block of G-protein signalling with PeTX GABA-A receptor antagonists SR 95531 and Picrotoxin generate smaller impact on RMS noise than after block of PKA with PKI.
MG-63 cells were treated with LPA (10 µM) alone or in combination with C3 (20 µM), PTX (Pertussis Toxin, 400 ng/ml) or H2L 5765834 (20 µM) for 3 h to follow COX-2 expression using Western blot. Pertussis Toxin inhibited COX-2 expression induced by LPA.
It was used to block gpcr response before hitting the cells with the ligand for receptor of interest