Pertussis Toxin

Catalog # Availability Size / Price Qty
3097/50U
Pertussis Toxin | CAS No. 70323-44-3 | G Protein (Heterotrimeric) Inhibitors
1 Image
Description: Catalyzes ADP-ribosylation of Gi, Go and Gt
Product Details
Citations (19)
Reviews (3)

Biological Activity

Bacterial toxin that catalyzes ADP-ribosylation of G-proteins Gi, Go and Gt. Impairs G protein heterotrimer interaction with receptors, blocking receptor coupling.

Technical Data

Storage:
Store at +4°C
CAS No:
70323-44-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Pertussis Toxin

The citations listed below are publications that use Tocris products. Selected citations for Pertussis Toxin include:

19 Citations: Showing 1 - 10

  1. Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro.
    Authors: Nepomuceno Et al.
    Front Pharmacol  2018;9:157
  2. Selective modulation of tonically active GABAA receptor functional subgroups by G-proteins and protein kinase C.
    Authors: O'Neill & Sylantyev
    Exp Biol Med (Maywood)  2018;243:1046
  3. Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and Ca2.
    Authors: Zhao Et al.
    Molecules  2018;23
  4. Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression.
    Authors: Li Et al.
    Theranostics  2017;7:4671
  5. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
    Authors: Yuan Et al.
    Am J Physiol Heart Circ Physiol  2016;7:11024
  6. A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocy. green dye.
    Authors: Sim Et al.
    Int J Cancer  2015;8:1479
  7. Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica.
    Authors: Jones Et al.
    Acta Neuropathol Commun  2015;3:28
  8. SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II.
    Authors: Choi Et al.
    J Neurosci  2015;136:E219
  9. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
    Authors: Stott Et al.
    Dis Model Mech  2015;112:6497
  10. The role of lipoprotein-associated phospholipase A2 in a murine model of experimental autoimmune uveoretinitis.
    Authors: Crawford Et al.
    PLoS One  2015;10:e0122093
  11. Protein z exerts pro-angiogenic effects and upregulates CXCR4.
    Authors: Butschkau Et al.
    PLoS One  2014;9:e113554
  12. Tissue-resident exhausted effector memory CD8+ T cells accumulate in the retina during chronic experimental autoimmune uveoretinitis.
    Authors: Boldison Et al.
    J Immunol  2014;192:4541
  13. Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death.
    Authors: Rimmerman Et al.
    Cell Death Dis  2013;4:e949
  14. Cytoskeletal role in protection of the failing heart by β-adrenergic blockade.
    Authors: Cheng Et al.
    Proc Natl Acad Sci U S A  2012;302:H675
  15. Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity.
    Authors: Wydeven Et al.
    Proc Natl Acad Sci U S A  2012;109:21492
  16. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.
    Authors: Park Et al.
    Neuron  2011;31:18433
  17. Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.
    Authors: Schutsky Et al.
    J Neurosci  2011;31:14172
  18. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984
  19. Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic β2-adrenoceptor activation.
    Authors: Nagaraja Et al.
    Nat Commun  1999;127:1099

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Pertussis toxin impacts GABA-A receptor effects
By Anonymous on 07/21/2019
Species: Rat

Pertussis toxin (PeTX) was used to compare effects of PKA and G-protein signalling on root mean square noise (RMS) produced by GABA-A receptors in electrophysiological recording. We found that after block of G-protein signalling with PeTX GABA-A receptor antagonists SR 95531 and Picrotoxin generate smaller impact on RMS noise than after block of PKA with PKI.

PMID: 30205722

Pertussis Toxin inhibits LPA induced COX-2 expression in osteosarcoma cells
By Christopher Trummer on 10/23/2018
Species: Human

MG-63 cells were treated with LPA (10 µM) alone or in combination with C3 (20 µM), PTX (Pertussis Toxin, 400 ng/ml) or H2L 5765834 (20 µM) for 3 h to follow COX-2 expression using Western blot. Pertussis Toxin inhibited COX-2 expression induced by LPA.


Fast delivery and great quality
By Anonymous on 07/17/2017
Species: Mouse

It was used to block gpcr response before hitting the cells with the ligand for receptor of interest


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